Role of cytochrome P450 and glutathione S-transferase α in the metabolism and cytotoxicity of trichloroethylene in rat kidney

Biochemical Pharmacology

Volumn 59, Issue 5, 2000, Pages 531-543

  Cummings, Brian S ^a   Parker, Jean C ^b   Lash, Lawrence H ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Cytochrome P450; Distal tubular; GSH conjugation; Kidney; Nephron heterogeneity; Proximal tubular; Trichloroethylene

Indexed keywords

BROMSULFOPHTHALEIN; CYTOCHROME P450; CYTOCHROME P450 ISOENZYME; DIMETHYLNITROSAMINE DEMETHYLASE; GLUTATHIONE TRANSFERASE; ISOENZYME; S (1,2 DICHLOROVINYL)GLUTATHIONE; TRICHLOROETHYLENE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONJUGATION; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; ENZYME KINETICS; ENZYME SPECIFICITY; FEEDBACK SYSTEM; KIDNEY CORTEX; KIDNEY DISTAL TUBULE; KIDNEY PROXIMAL TUBULE; LIVER CYTOSOL; MALE; METABOLITE; MODEL; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; XENOBIOTIC METABOLISM;

ANIMALS; BIOTRANSFORMATION; CYTOCHROME P-450 ENZYME SYSTEM; CYTOSOL; DRUG INTERACTIONS; ENZYME INHIBITORS; GLUTATHIONE; GLUTATHIONE TRANSFERASE; ISOENZYMES; KIDNEY TUBULES, DISTAL; KIDNEY TUBULES, PROXIMAL; KINETICS; MALE; RATS; RATS, INBRED F344; TRICHLOROETHYLENE;

EID: 0033958342     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00374-3     Document Type: Article

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