Identification in rat bile of glutathione conjugates of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether, a nephrotoxic degradate of the anesthetic agent sevoflurane

Chemical Research in Toxicology

Volumn 9, Issue 2, 1996, Pages 555-561

  Jin, Lixia ^a   Davis, Margaret R ^a,b   Kharasch, Evan D ^a   Doss, George A ^b   Baillie, Thomas A ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,2 DIFLUORO 1 (TRIFLUOROMETHYL)VINYL FLUOROMETHYL ETHER; CYSTEINE CONJUGATE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; INHALATION ANESTHETIC AGENT; LYASE; SEVOFLURANE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; CONTROLLED STUDY; DIASTEREOISOMER; DRUG ACTIVATION; DRUG METABOLISM; ENZYME MECHANISM; GLUTATHIONE METABOLISM; INTRAPERITONEAL DRUG ADMINISTRATION; LIQUID CHROMATOGRAPHY; MALE; NEPHROTOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; TANDEM MASS SPECTROMETRY;

ANIMALS; BILE; CHROMATOGRAPHY, LIQUID; ETHERS; GLUTATHIONE; HYDROCARBONS, FLUORINATED; KIDNEY; MALE; MASS SPECTROMETRY; METHYL ETHERS; MICROSOMES, LIVER; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0029917278     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx950162m     Document Type: Article

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