Gabapentin-lactam (8-aza-spiro[5,4]decan-9-on; GBP-L) inhibits oxygen glucose deprivation-induced [3H]glutamate release and is a neuroprotective agent in a model of acute retinal ischemia

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 362, Issue 1, 2000, Pages 74-81

  Jehle, Thomas ^a   Lagrèze, Wolf A ^b   Blauth, Eckard ^a   Knörle, Rainer ^c   Schnierle, Peter ^c   Lücking, Carl Hermann ^a   Feuerstein, Thomas J ^a  

^a Sektion Klinische N der N U   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c Inst fur Biochemische A   (Germany)

Author keywords

Gabapentin lactam; Glutamate release; Ischemia; K(ATP) channel; Neuroprotection; Retinal ganglion cells

Indexed keywords

8 AZA SPIRO[5,4]DECAN 9 ON; GABAPENTIN LACTAM; GLIBENCLAMIDE; GLUTAMIC ACID; LACTAM DERIVATIVE; RILUZOLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN SLICE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; EXOCYTOSIS; HIPPOCAMPUS; MEMBRANE DEPOLARIZATION; NEUROPROTECTION; NEUROTRANSMITTER RELEASE; NONHUMAN; RAT; RETINA GANGLION CELL; RETINA ISCHEMIA;

EID: 0033935668     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002100000265     Document Type: Article

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