Riluzole does not attenuate increases in hippocampal glutamate concentrations in a rabbit model of repeated transient global cerebral ischemia

Anesthesia and Analgesia

Volumn 86, Issue 1, 1998, Pages 128-133

  Kwon, Jae Young ^a   Bacher, Andreas ^b   Zornow, Mark H ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMIC ACID; HALOTHANE; RILUZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DIALYSATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; MALE; MICRODIALYSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ANIMALS; ELECTROENCEPHALOGRAPHY; GLUTAMIC ACID; HIPPOCAMPUS; ISCHEMIC ATTACK, TRANSIENT; MALE; NEUROPROTECTIVE AGENTS; RABBITS; RECEPTORS, N-METHYL-D-ASPARTATE; RILUZOLE; SODIUM CHANNEL BLOCKERS;

EID: 0031975562     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-199801000-00026     Document Type: Article

References (31)

1. Dessi F, Ben-Ari Y, Charriaut-Marlangue C. Riluzole prevents anoxic injury in cultured cerebellar granule neurons. Eur J Pharmacol 1993;250:325-8.
2. Estevez AG, Stutzmann JM, Barbeito L. Protective effect of riluzole on excitatory amino acid-mediated neurotoxicity in motoneuron-enriched cultures. Eur J Pharmacol 1995;280:47-53.
3. Pratt J, Rataud J, Bardot F, et al. Neuroprotective actions of riluzole in rodent models of global and focal cerebral ischaemia. Neurosci Lett 1992;140:225-30.
4. Malgouris C, Bardot F, Daniel M, et al. Riluzole, a novel anti-glutamate, prevents memory loss and hippocampal neuronal damage in ischemic gerbils. J Neurosci 1989;9:3720-7.
5. Romettino S, Lazdunski M, Gottesmann C. Anticonvulsant and sleep-waking influences of riluzole in a rat model of absence epilepsy. Eur J Pharmacol 1991;199:371-3.
6. Bensimon G, Lacomblez L, Meininger V, and the ALS/Riluzole Study Group. A controlled trial of riluzole in amyotrophic lateral sclerosis. N Engl J Med 1994;330:585-91.
7. Grieco G, d'Hollosy M, Culliford AT, Jonas S. Evaluating neuroprotective agents for clinical anti-ischemic benefit using neurological and neurophysiological changes after cardiac surgery under cardiopulmonary bypass: methodological strategies and results of a double-blind, placebo-controlled trial of GM1 ganglioside. Stroke 1996;27:858-74.
8. Gold JP, Charlson ME, Williams-Russo P, et al. Improvement of outcomes after coronary artery bypass: a randomized trial comparing intraoperative high versus low mean arterial pressure. J Thorac Cardiovasc 1995;110:1302-11.
9. Benveniste H, Jorgensen MB, Sandberg M, et al. Ischemic damage in hippocampal CA1 is dependent on glutamate release and intact innervation from CA3. J Cereb Blood Flow Metab 1989;9: 629-39.
10. Benveniste H, Drejer J, Schousboe A, Diemer NH. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem 1984;43:1369-74.
11. Martin D, Thompson MA, Nadler JV. The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CAl. Eur J Pharmacol 1993;250:473-6.
12. Cheramy A, Barbeito L, Godeheu G, Glowinski J. Riluzole inhibits the release of glutamate in the caudate nucleus of the cat in vivo. Neurosci Lett 1992;147:209-12.
13. Hebert T, Drapeau P, Pradier L, Dunn RJ. Block of the rat brain IIA sodium channel alpha subunit by the neuroprotective drug riluzole. Mol Pharmacol 1994;45:1055-60.
14. Wu G, Kim H, Zornow M. Transient brain ischemia in rabbits: the effect of omega-conopeptide MVIIC on hippocampal excitatory amino acids. Brain Res 1995;692:118-24.
15. Baker AJ, Zornow MH, Grafe MR, et al. Hypothermia prevents ischemia-induced increases in hippocampal glycine concentrations in rabbits. Stroke 1991;22:666-73.
16. Matuszewski BK, Givens RS, Srinivasachar K, et al. N-substituted 1-cyanobenz[f]isoindole: evaluation of fluorescence efficiencies of a new fluorogenic label for primary amines and amino acids. Anal Chem 1987;59:1102-5.
17. Rothman SM, Olney JW. Glutamate and the pathophysiology of hypoxic-ischemic brain damage. Ann Neurol 1986;19:105-11.
18. Globus MY, Busto R, Dietrich WD, Martinez E, et al. Effect of ischemia on the in vivo release of striatal dopamine, glutamate, and gamma-aminobutyric acid studied by intracerebral microdialysis. J Neurochem 1988;51:1455-64.
19. Busto R, Globus MY, Dietrich WD, et al. Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain. Stroke 1989;20:904-10.
20. Illievich UM, Zornow MH, Choi KT, et al. Effects of hypothermic metabolic suppression on hippocampal glutamate concentrations after transient global cerebral ischemia. Anesth Analg 1994;78:905-11.
21. Bacher A, Zornow MH. Lamotrigine inhibits extracellular glutamate accumulation during transient global cerebral ischemia in rabbits. Anesthesiology 1997;86:459-63.
22. Hauptman M, Nelson D, Wilson DF, Erecinska M. Neurotransmitter amino acids in the CNS. II. Some changes in amino acid levels in rat brain synaptosomes during and after in vitro anoxia and simulated ischemia. Brain Res 1984;304:23-35.
23. Siesjö BK. Pathophysiology and treatment of focal cerebral ischemia. Part I. Pathophysiology. J Neurosurg 1992;77:169-84.
24. Taylor CP, Geer JJ, Burke SP. Endogenous extracellular glutamate accumulation in rat neocortical cultures by reversal of the transmembrane sodium gradient. Neurosci Lett 1992;145: 197-200.
25. Chen J, Graham SH, Simon RP. A comparison of the effects of a sodium channel blocker and an NMDA antagonist upon extracellular glutamate in rat focal cerebral ischemia. Brain Res 1995; 699:121-4.
26. MacIver MB, Amagasu SM, Mikulec AA, Monroe FA. Riluzole anesthesia: use-dependent block of presynaptic glutamate fibers. Anesthesiology 1996;85:626-34.
27. Wahl F, Allix M, Plotkine M, Boulu RG. Effect of riluzole on focal cerebral ischemia in rats. Eur J Pharmacol 1993;230:209-14.
28. Bryson HM, Fulton B, Benfield P. Riluzole: a review of its pharmacodynamics and pharmacokinetic properties and therapeutic potential in amyotrophic lateral sclerosis. Drugs 1996;52: 549-63.
29. Debono MW, Le Guern J, Canton T, et al. Inhibition by riluzole of electrophysiological responses mediated by rat kainate and NMDA receptors expressed in Xenopus oocytes. Eur J Pharmacol 1993;235:283-9.
30. Malgouris C, Daniel M, Doble A. Neuroprotective effects of riluzole on N-methyl-D-aspartate-or veratridine-induced neurotoxicity in rat hippocampal slices. Neurosci Lett 1994;177: 95-9.
31. Hubert JP, Delumeau JC, Glowinski J, et al. Antagonism by riluzole of entry of calcium evoked by NMDA and veratridine in rat cultured granule cells: evidence for a dual mechanism of action. Br J Pharmacol 1994;113:261-7.