Helicobacter pylori vacA genotypes and cagA gene in a series of 383 H. pylori-positive patients

Zeitschrift fur Gastroenterologie

Volumn 38, Issue 7, 2000, Pages 559-564

  Rudi, J ^a   Kuck, D ^a   Rudy, A ^a   Sieg, A ^a   Maiwald, M ^a   Stremmel, W ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Gastric Biopsies; Helicobacter Pylori; Peptic Ulcer Disease; Polymerase Chain Reaction

Indexed keywords

BACTERIAL TOXIN; CYTOTOXIN;

ADULT; AGED; ARTICLE; BACTERIAL GENE; BACTERIAL VIRULENCE; CONTROLLED STUDY; FEMALE; GENOTYPE; HELICOBACTER PYLORI; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PEPTIC ULCER; POLYMERASE CHAIN REACTION; STOMACH BIOPSY; STOMACH CANCER;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BACTERIAL TOXINS; BASE SEQUENCE; CHI-SQUARE DISTRIBUTION; FEMALE; GENES, BACTERIAL; GENOTYPE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; VACUOLES; VIRULENCE;

EID: 0033846332     PISSN: 00442771     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2000-7449     Document Type: Article

References (46)

1. Unidentified curved bacilli on gastric epithelium in active chronic gastritis
2. Effect of ranitidine and amoxicillin plus metronidazole on the eradication of Helicobacter pylori in the pathogenesis of duodenal and gastric ulcer
3. Helicobacter pylori infection and the risk of gastric carcinoma
4. Helicobacter-pylori-associated gastritis and primary B-cell gastric lymphoma
5. Helicobacter pylori gastritis and gastric MALT-lymphoma
6. Cytotoxic activity in broth-culture filtrates of Campylobacter pylori
7. Cytotoxin production by Campylobacter pylori strains isolated from patients with peptic ulcers and from patients with chronic gastritis
8. Characterisation of and human serologic response to proteins in Helicobacter pylori broth culture supernatants with vacuolizing cytotoxin activity
9. Mucosal IgA recognition of Helicobacter pylori 120 kDA protein, peptic ulceration and gastric pathology
10. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer
11. Correlation between vacuolating cytotoxin production by Helicobacter pylori isolates in vitro and in vivo
12. Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains
13. Genetic analysis of the Helicobacter pylori vacuolating cytotoxin: Structural similarities with the IgA protease type of exported protein
14. Role of the vacuolating toxin from Helicobacter pylori in the pathogenesis of duodenal and gastric ulcer
15. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori
16. Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori
17. Diversity of Helicobacter pylori vacA and cagA genes and relationship to VacA and CagA protein expression, cytotoxin production, and associated diseases
18. Clinical relevance of the cagA, vacA, and iceA status of Helicobacter pylori
19. Cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors
20. Helicobacter pylori picB, a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of IL-8 in gastric epithelial cells
21. Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: Evidence of linkage to cytotoxin production
22. Expression of 120 kilodalton protein and cytotoxicity in Helicobacter pylori
23. Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxin
24. Serum antibodies against Helicobacter pylori proteins CagA and VacA are associated with increased risk for gastric adenocarcinoma
25. Clinical and histological associations of cagA and vacA genotypes in Helicobacter pylori
26. Clinical outcome after infection with Helicobacter pylori does not appear to be reliably predicted by the presence of any of the genes of the pathogenicity island
27. Geographic distribution of vacA allelic types of Helicobacter pylori
28. Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome: Studies in four different countries
29. Differing patterns of Helicobacter pylori gastritis in patients with duodenal, prepyloric, and gastric ulcer disease
30. Duodenal Helicobacter pylori infection differs in cagA genotype between asymptomatic subjects and patients with duodenal ulcers
31. Involvement of the CD95 (APO-1/ Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis
32. Lack of effect of treating Helicobacter pylori infection in patients with nonulcer dyspepsia
33. Symptomatic benefit from eradicating Helicobacter pylori infection in patients with nonulcer dyspepsia
34. Direct detection and amplification of Helicobacter pylori ribosomal 16S gene segments from gastric endoscopic biopsies
35. Comparison of PCR and other diagnostic techniques for detection of Helicobacter pylori infection in dyspeptic patients
36. Accuracy of invasive and noninvasive tests to diagnose Helicobacter pylori infection after antibiotic treatment
37. Direct determination of Helicobacter pylori vacA genotypes and cagA gene in gastric biopsies and relationship to gastrointestinal diseases
38. Comparison of polymerase chain reaction and conventional culture for the detection of legionellas in hospital water
39. Identification of murine Helicobacters by PCR and restriction enzyme analyses
40. Characterization of contaminating DNA in Taq polymerase which occurs during amplification with a primer set for Legionella 5S ribosomal RNA
41. VacA genotypes and genetic diversity in clinical isolates of Helicobacter pylori
42. Identification and analysis of a new vacA genotype variant of Helicobacter pylori in different patient groups in Germany
43. Helicobacter pylori cagA status, vacA genotypes and ulcer disease
44. Current European concepts in the management of Helicobacter pylori infection. The Maastricht Consensus Report
45. Typing of Helicobacter pylori vacA gene and detection of cagA gene by PCR and reverse hybridization
46. CagA positive and negative Helicobacter pylori strains are simultaneously present in the stomach of most patients with non-ulcer dyspepsia: Relevance of histological damage