A touching case of channel regulation: The ATP-sensitive K+ channel

Current Opinion in Neurobiology

Volumn 8, Issue 3, 1998, Pages 316-320

  Tucker, Stephen J ^a   Ashcroft, Frances M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; POTASSIUM CHANNEL; PROTEIN SUBUNIT; SULFONYLUREA;

PRIORITY JOURNAL; REVIEW;

EID: 0032101992     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(98)80055-X     Document Type: Article

References (48)

1. Ashcroft FM, Ashcroft SJH. Properties and functions of ATP-sensitive K-channels. Cell Signal. 2:1990;197-214.
2. Nichols CG, Lederer WJ. Adenosine triphosphate-sensitive potassium channels in the cardiovascular system. Am J Physiol. 261:1991;H1675-H1686.
3. Quayle JM, Nelson MT, Standen NB. ATP-sensitive and inwardly-rectifying potassium channels in smooth muscle. Physiol Rev. 77:1997;1165-1232.
4. Ashcroft FM, Rorsman P. Electrophysiology of the pancreatic β-cell. Prog Biophys Mol Biol. 54:1989;87-143.
5. Edwards G, Weston AH. The pharmacology of ATP-sensitive potassium channels. Annu Rev Pharm Toxicol. 33:1993;597-637.
6. Aguilar-Bryan L, Nichols CG, Wechsler SW, Clement JP, Boyd AE, González G, Herrera-Sosa H, Nguy K, Bryan J, Nelson DA. Cloning of the β-cell high-affinity sulphonylurea receptor: a regulator of insulin secretion. Science. 268:1995;423-425.
7. Higgins C. ABC transporter: from microorganisms to man. Annu Rev Cell Biol. 8:1992;67-113.
8. Tusnady GE, Gakos E, Varadi A, Sarkadi B. Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters. FEBS Lett. 402:1997;1-3.
9. KATP: an inward rectifier subunit plus the sulphonylurea receptor. Science. 270:1995;1166-1169.
10. Sakura H, Ämmälä C, Smith PA, Gribble FM, Ashcroft FM. Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel expressed in pancreatic β-cells, brain, heart and skeletal muscle. FEBS Lett. 377:1995;338-344.
11. Gribble FM, Ashfield R, Ämmälä C, Ashcroft FM. Properties of cloned ATP-sensitive K-currents expresed in Xenopus oocytes. J Physiol. 498:1997;87-98.
12. + channels. Neuron. 16:1996;1011-1017.
13. ATP channels. Diabetes. 45:1996;1439-1445.
14. + channel. J Biol Chem. 271:1996;24321-24325.
15. Liss B, Bruns R, Roper J. Single cell RT-PCR detection of ATP-sensitive potassium channel subunits: a heterogeneous expression pattern in dopaminergic neurons. Pflügers Arch. 434S:1997;R105.
16. ATP channel-forming Kir6.2 subunit and the sulphonylurea receptor SUR1 in rodent brain. FEBS Lett. 401:1996;59-64.
17. + channels. Pflügers Arch. 415:1990;479-483.
18. + channels. Br J Pharmacol. 101:1990;531-540.
19. ATP channel lies on the Kir subunit rather than on SUR.
20. Ämmälä C, Moorhouse A, Ashcroft FM. The sulphonylurea receptor confers diazoxide sensitivity on the inwardly-rectifyng K-channel, Kir6.1. J Physiol. 494:1996;709-714.
21. ATP channel is an octameric complex comprising four Kir6.2 and four SUR1 subunits.
22. Adelman JP. Proteins that interact with the pore-forming subunits of voltage-gated ion channels. Curr Opin Neurobiol. 5:1995;286-295.
23. ATP channel.
24. ATP channel using fusion proteins to control the stoichiometry of the expressed subunits.
25. Nichols CG, Shyng S-L, Nestorowicz A, Glaser B, Clement JP, Gonzalez G, Aguilar-Bryan L, Permutt MA, Bryan J. Adenosine disphophate as an intracellular regulator of insulin secretion. Science. 272:1996;1785-1787.
26. Gribble FM, Tucker SJ, Ashcroft FM. The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by mgADP and diazoxide. EMBO J. 16:1997;1145-1152.
27. ATP currents by guanine nucleotides is mediated by different channel subunits. Proc Natl Acad Sci USA. 1997 vn 94;8872-8877.
28. Shyng SL, Ferrigni T, Nichols CG. Regulation of KATP channel activity by diazoxide and MgADP: distinct functions of the two nucleotide binding folds of the sulphonylurea receptor. J Gen Physiol. 110:1997;643-654.
29. Tucker SJ, Gribble FM, Zhao C, Trapp S, Ashcroft FM. Truncation of Kir6.2 produces ATP-sensitive K-channels in the absence of the sulphonylurea receptor. of outstanding interest Nature. 387:1997;179-183 Demonstrates that partial deletion of the carboxy terminus of Kir6.2 enables its functional expression independently of SUR. By comparing the properties of this truncated Kir6.2 expressed with, or without, SUR1, it was shown that Kir6.2 forms an ATP-inhibitable pore while SUR1 endows sensitivity to sulphonylureas, K-channel openers and the potentiatory action of MgADP.
30. ATP channels is mediated by Kir6.2. Proc Natl Acad Sci USA. 94:1997;11716-11720.
31. ATP channels by the Kir6.2 subunit. of special interest J Gen Physiol. 110:1997;141-153 Shows that mutation of N160 in transmembrane domain 2 (TM2) of Kir6.2 not only affects the rectification properties of the pore, but also enhances the open probability and simultaneously decreases ATP sensitivity. This result suggests that the mutations may alter the channel ATP sensitivity via their effects on gating rather than by affecting ATP binding.
32. ATP channel produced by sulphonylureas. The data suggest that tolbutamide may abolish the stimulatory effect of MgADP. This reveals an additional inhibitory effect of the nucleotide which sums with that of tolbutamide and causes an apparent (rather than real) increase in the blocking efficacy of the drug.
33. Ueda K, Inagaki N, Seino S. MgADP antagonism to Mg-independent ATP binding of the sulfonylurea receptor SUR1. of outstanding interest J Biol Chem. 272:1997;22983-22986 The first study to demonstrate biochemically nucleotide binding to the sulphonylurea receptor SUR1.
34. Thomas PM, Cote GJ, Wohlk N, Haddad B, Mathew PM, Ralb W, Aguilar-Bryan L, Gagel RF, Bryan J. Mutations in the sulphonylurea receptor gene in familial persistent hyperinsulinaemic hypoglycaemia of infancy. Science. 268:1995;425-429.
35. Thomas P, Ye Y, Lightner E. Mutations in the pancreatic islet inward rectifier also lead to familial persistent hyperinsulinaemic hypoglycaemia of infancy. Hum Mol Genet. 5:1996;1809-1812.
36. ATP channels in pancreatic β-cells causes persistent hyperinsulinemic hypoglycemia of infancy. Nature Med. 2:1996;1344-1347.
37. ATP channel. Proc Natl Acad Sci USA. 94:1997;11969-11973.
38. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 372:1994;425-432.
39. ATP channels in pancreatic β-cells, a finding that explains the ability of the hormone to enhance insulin secretion.
40. ATP channel found in ventromedial hypothalamic neurones, as demonstrated by recording from both brain slces and isolated cells.
41. + channels by GTP-binding proteins in a mammalian cell line. J Physiol. 507:1998;315-324.
42. + conductance in pancreatic zymogen granules: block by glyburide and activation by diazoxide. J Membr Biol. 129:1992;253-266.
43. Ozanne SE, Guest PC, Huton JC, Hales CN. Intracellular localization and molecular heterogeneity of the sulphonylurea receptor in insulin-secreting cells. Diabetologia. 38:1995;277-282.
44. Garlid KD. Cation transport in mitochondria - the potassium cycle. Biochim Biophys Acta. 1275:1996;123-126.
45. + channels in mitochondria. Biochem Biophys Res Commun. 241:1997;693-697.
46. Braun M, Anderie I, Thévenod F. Evidence for a 65 kDa sulfonylurea receptor in rat pancreatic zymogen granule membranes. FEBS Lett. 411:1997;255-259.
47. 3H]glimepride. Biochim Biophys Acta. 1191:1994;278-290.
48. Leonhardt N, Marin E, Vavasseur A, Forestier C. Evidence for the existence of a sulfonylurea-receptor-like protein in plants: Modulation of stomatal movements and guard cell potassium channels by sulfonylureas and potassium channel openers. Proc Natl Acad Sci USA. 94:1997;14156-14161.