The evolution of DNA vaccines

Current Opinion in Molecular Therapeutics

Volumn 2, Issue 4, 2000, Pages 441-447

  Apostolopoulos, V ^a   Plebanski, M ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Cancer; Cytokines; DNA vaccines; Immunotherapy; Infectious disease; Optimized vaccines; Primates; Prime boost

Indexed keywords

DNA VACCINE; RECOMBINANT DNA; VIRUS VECTOR;

ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ARTICLE; CANCER INHIBITION; DRUG MECHANISM; GENE GUN; HUMAN; IMMUNOMODULATION; INFECTION; MOUSE; NONHUMAN; RHESUS MONKEY; VACCINATION;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS; BIOTECHNOLOGY; CLINICAL TRIALS; DNA, RECOMBINANT; HUMANS; LYMPHOCYTE ACTIVATION; PRIMATES; SAFETY; T-LYMPHOCYTES; VACCINES, DNA;

ANIMALIA; BACTERIA (MICROORGANISMS); MACACA MULATTA; PRIMATES; VARIOLA VIRUS;

EID: 0033844708     PISSN: 14648431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. Th1/Th2 cells
2. Oxidative/reductive conjugation of mannan to antigen selects for T1 or T2 immune responses
3. Aldehyde-mannan antigen complexes target the MHC class I antigen-presentation pathway
4. Separation of IL-4 production from Th cell proliferation by an altered T-cell receptor ligand
5. Interleukin 10-mediated immunosuppression by a variant CD4 T-cell epitope of Plasmodium falciparum
6. Association of malaria parasite population structure, HLA, and immunological antagonism
7. Altered peptide ligands narrow the repertoire of cellular immune responses by interfering with T-cell priming
8. Differential activation of proliferation and cytotoxicity in human T-cell lymphotropic virus type I Tax-specific CD8 T-cells by an altered peptide ligand
9. Broadly distributed T-cell reactivity, with no immunodominant loci, to the pre-erythrocytic antigen thrombospondin-related adhesive protein of Plasmodium falciparum in West Africans
10. Flow cytometric measurement of intracellular cytokines detects immune responses in MUC1 immunotherapy
11. Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis
12. Direct gene transfer into mouse muscle in vivo
13. Genetic immunization is a simple method for eliciting an immune response
14. Heterolgous protection against influenza by injection of DNA encoding a viral protein
15. DNA vaccines: Protective immunizations by parenteral, mucosal and gene gun inoculations
16. Protection against a lethal challenge with SV40-transformed cells by the direct injection of DNA-encoding SV40 large tumor antigen
17. DNA vaccines: Immunology, application and optimization
18. First human trial of a DNA-based vaccine for treatment of human immunodeficlency virus type 1 infection: Safety and host response
19. Enhancement of cellular immune response in HIV-1 seropositive individuals: A DNA-based trial
20. Safety, tolerability and humoral immune responses after intramuscular administration of a malaria DNA vaccine to healthy adult volunteers
21. Induction of cytotoxic T-lymphocytes and antitumor immunity with DNA vaccines expressing single T-cell epitopes
22. Costimulation provided by DNA immunization enhances antitumor immunity
23. DNA immunization with minigenes: Low frequency of memory cytotoxic T-lymphocytes and inefficient antiviral protection are rectified by ubiquitination
24. A 'string-of-beads' vaccine, comprising linked minigenes, confers protection from lethal-dose virus challenge
25. Delivery of multiple CD8 cytotoxic T-cell epitopes by DNA vaccination
26. DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: Immunogenicity in mice
27. Protection by minigenes: A novel approach of DNA vaccines
28. Cytotoxic T-cell responses to DNA vaccination: Dependence on antigen presentation via class II MHC
29. A nine-amino acid peptide from IL-1β augments antitumor immune responses induced by protein and DNA vaccines
30. Modulation of amplitude and direction of in vivo immune responses by co-administration of cytokine gene expression cassettes with DNA immunogens
31. Improvement of hepatitis B virus DNA vaccines by plasmids co-expressing hepatitis B surface antigen and interleukin-2
32. Enhancement of cellular and humoral immune responses to hepatitis C virus core protein using DNA-based vaccines augmented with cytokine-expressing plasmids
33. Cytokine molecular adjuvants modulate immune responses induced by DNA vaccine constructs for HIV-1 and SIV
34. Engineering of in vivo immune responses to DNA Immunization via codelivery of costimulatory molecule genes
35. CD40 Ligand/trimer DNA enhances both humoral and cellular immune responses and induces protective immunity to infectious and tumor challenge
36. Enhancement of DNA vaccine potency by linkage of antigen gene to an HSP70 gene
37. Enhancement of DNA vaccine potency using conventional aluminum adjuvants
38. Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo
39. Route and method of delivery of DNA vaccine influence immune responses in mice and non-human primates
40. DNA vaccination against virus infection and enhancement of antiviral immunity following consecutive immunization with DNA and viral vectors
41. The prime-boost strategy: Exciting prospects for improved vaccination
42. Enhanced T-cell immunogenicity and protective efficacy of a human immunodeficiency virus type 1 vaccine regimen consisting of consecutive priming with DNA and boosting with recombinant fowipox virus
43. Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations
44. Enhanced immunogenicity for CD8+ T-cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara
45. Induction of CD8+ T-cells using heterologous prime-boost immunization strategies
46. Gene gun intradermal DNA immunization followed by boosting with modified vaccinia virus Ankara: Enhanced CD8+ T-cell immunogenicity and protective efficacy in the influenza and malaria models
47. Ty virus-like particles, DNA vaccines and modified vaccinia virus ankara, comparisons and combinations
48. Protection from Plasmodium berghei infection by priming and boosting T-cells to a single class I-restricted epitope with recombinant carriers suitable for human use
49. A protein particle vaccine containing multiple malaria epitopes
50. Preclinical development of a multi-CTL epitope-based DNA prime MVA boost vaccine for AIDS
51. Induction of AIDS virus-specific CTL activity in fresh, unstimulated peripheral blood lymphocytes from rhesus macaques vaccinated with a DNA prime/modified vaccinia virus ankara boost regimen
52. Augmentation of immune responses to HIV-1 and simian immunodeficiency virus DNA vaccines by IL-2/Ig plasmid administration in rhesus monkeys
53. Modulation of antigen-specific humoral responses in rhesus macaques by using cytokine cDNAs as DNA vaccine adjuvants
54. Antigen-specific humoral and cellular immune responses can be modulated in rhesus macaques through the use of IFNγ, IL-12 or IL-18 gene adjuvants
55. An anti-HIV strategy combining chemotherapy and therapeutic vaccination
56. Polynucleotide immunization of non-human primates against carcinoembryonic antigen
57. Vectors to achieve selective expression of vaccine antigens within eukaryotic cells using Salmonella spp as carrier strains
58. An autologous oral DNA vaccine protects against murine melanoma
59. Genomics: From novel genes to new therapeutics in parasitology
60. DNA immunization protects non-human primates against rabies virus