Vectors to achieve selective expression of vaccine antigens within eukaryotic cells using Salmonella spp. as carrier strains

FEMS Microbiology Letters

Volumn 182, Issue 2, 2000, Pages 219-223

  Basso, Holger ^a   Rohde, Manfred ^a   Guzmán, Carlos A ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

Expression vector; Pertussis toxin; Plasmid; Promoter; Vaccine

Indexed keywords

ANTIGEN; PERTUSSIS TOXIN; RECOMBINANT ANTIGEN; RIBOSOME RNA; UNCLASSIFIED DRUG; VACCINE;

ARTICLE; BACTERIOPHAGE T7; CELL LINE; CONTROLLED STUDY; ESCHERICHIA COLI; EUKARYOTIC CELL; EXPRESSION VECTOR; GENE CASSETTE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INFECTION; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; RECOMBINANT DNA TECHNOLOGY; RNA TRANSLATION; SALMONELLA; SALMONELLA TYPHIMURIUM; TRANSMISSION ELECTRON MICROSCOPY;

ANTIGENS, BACTERIAL; BACTERIAL VACCINES; CELL LINE; ELECTROPORATION; GENETIC VECTORS; HUMANS; MICROSCOPY, ELECTRON; PERTUSSIS TOXIN; PLASMIDS; PROMOTER REGIONS (GENETICS); RECOMBINANT PROTEINS; SALMONELLA TYPHIMURIUM; TRANSFORMATION, BACTERIAL; VACCINES, SYNTHETIC; VIRULENCE FACTORS, BORDETELLA;

ESCHERICHIA COLI; EUKARYOTA; SALMONELLA; SALMONELLA TYPHI; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0033986898     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(99)00593-5     Document Type: Article

References (11)

1. Chatfield S.N., Charles I.G., Makoff A.J., Oxer M.D., Dougan G., Pickard D., Slater D., Fairweather N.F. Use of nirB promoter to direct the stable expression of heterologous antigens in Salmonella oral vaccine strain: development of signal-dose oral tetanus vaccine. Bio/Technology. 10:1992;888-892.
2. Everest P., Frankel G., Li J., Lund P., Chatfield S., Dougan G. Expression of LacZ from the htrA, nirB and groE promoters in a Salmonella vaccine strain: influence of growth in mammalian cells. FEMS Microbiol. Lett. 126:1995;97-102.
3. Hohmann E.L., Oletta C.A., Loomis W.P., Miller S.I. Macrophage-inducible expression of a model antigen in Salmonella typhimurium enhances immunogenicity. Proc. Natl. Acad. Sci. USA. 92:1995;2904-2908.
4. Staendner L.H., Rohde M., Timmis K.N., Guzmán C.A. Identification of Salmonella typhi promoters activated by invasion of eukaryotic cells. Mol. Microbiol. 18:1995;891-902.
5. Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
6. O'Callaghan D., Charbit A. High efficiency transformation of Salmonella typhimurium and Salmonella typhi by electroporation. Mol. Gen. Genet. 223:1990;156-158.
7. Roth J., Bendayan M., Carlemanlm E., Villinger W., Garavito M. Enhancement of structural preservation and immunocytochemical staining in low temperature embedded pancreatic tissue. J. Histochem. Cytochem. 29:1981;663-669.
8. Herrero M., de Lorenzo V., Timmis K.N. Transposon vectors containing non-antibiotic resistance selection markers for cloning and stable chromosomal insertion of foreign genes in gram-negative bacteria. J. Bacteriol. 172:1990;6557-6567.
9. Elliot T., Geiduschek E.P. Defining a bacteriophage T4 late promotor: absence of a '-35' region. Cell. 36:1984;211-219.
10. Schauder B., Blocker H., Frank R., McCarthy J.E. Inducible expression vectors incorporating the Escherichia coli atpE translational initiation region. Gene. 52:1987;279-283.
11. Brosius J., Lupski J.R. Plasmids for the selection and analysis of prokaryotic promoters. Methods Enzymol. 153:1987;54-68.