Aldehyde-mannan antigen complexes target the MHC class I antigen-presentation pathway

European Journal of Immunology

Volumn 30, Issue 6, 2000, Pages 1714-1723

  Apostolopoulos, Vasso ^a,b,c   Pietersz, Geoffrey A ^a,b,c   Gordon, Siamon ^a,b,c   Martinez Pomares, Luisa ^a,b,c   McKenzie, Lan F C ^a,b,c  

^a AUSTIN RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Aldehyde; Antigen presentation; Cytotoxic T lymphocyte; Immunotherapy; Mannose receptor

Indexed keywords

ALDEHYDE; BREFELDIN A; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MANNAN; MANNOSE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; ENDOPLASMIC RETICULUM; ENDOSOME; FLOW CYTOMETRY; GOLGI COMPLEX; IMMUNE RESPONSE; INTERNALIZATION; ISOTOPE LABELING; LYSOSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN TRANSPORT; RECEPTOR BINDING;

ALDEHYDES; ANIMALS; ANTIGEN PRESENTATION; CA-15-3 ANTIGEN; CALPAIN; CATHEPSIN B; CELLS, CULTURED; CHO CELLS; CRICETINAE; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; ENDOSOMES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; LECTINS, C-TYPE; LEUPEPTINS; LYSOSOMES; MACROPHAGES, PERITONEAL; MANNANS; MANNOSE-BINDING LECTINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED DBA; MULTIENZYME COMPLEXES; OXIDATION-REDUCTION; PEPTIDE FRAGMENTS; PROTEASOME ENDOPEPTIDASE COMPLEX; RECEPTORS, CELL SURFACE; SCHIFF BASES;

EID: 0034035702     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200006)30:6<1714::AID-IMMU1714>3.0.CO;2-C     Document Type: Article

References (31)

1. Mosmann, T. R. and Sad, S., The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 1996.17:138-146.
2. 2 immune responses. Proc. Natl. Acad. Sei. USA 1995. 92:10128-10132.
3. Apostolopoulos, V., Pietersz, G. A. and McKenzie, I. F. C., Cellmediated immune responses to MUC1 fusion protein coupled to mannan. Vaccine 1996.14: 930-938.
4. 2 (antibody) response to a mucin-1 tumor antigen. Vaccine 1997. 15: 1586-1593.
5. Apostolopoulos, V., Loveland, B. E., Pietersz, G. A. and McKenzie, I. F. C., CTL in mice immunized with human Mucin 1 are MHC-restricted. J. Immunol. 1995.155: 5089-5094.
6. Lees, C. J., Apostolopoulos, V. and McKenzie, l. F. C., Cytokine production from CD4 and CDS depleted splenocytes after immunization with mannan-MUC1 fusion protein in BALB/c mice. J. Interferon Cytokine Res. 1999. 19:1373-1379.
7. Wileman, T., Boshans, R. L. and Stahl, P., Uptake and transport of mannosylated ligands by alveolar macrophages. J. Biochem. 1985.260:7387-7393.
8. Epstein J, Eichbaum, Q., Sheriff, S. and Ezekowitz, R. A. B., The collectins in innate immunity. Curr. Opin. Immunol. 1996. 8: 29-35.
9. Tan, M. C., Mommaas, A. M., Drijfhout, J. W., Jordens, R., underwater, J. J., Verwierd, D, Mulder, A.A., van der Heiden, A.N., Scheidegger, D., Oomen, L.C.J.M., Ottenhoff, T.H.M., Tulp, A., Neefjes, J.J. and Koning, F., Mannose receptormediated uptake of antigens strongly enhances HLA Class IIrestricted antigen presentation by cultured dendritic cells. Eur. J. Immunol. 1997. 27: 2426-2435.
10. Engering, A. J, Cella, M., Fluitsma, D., Brockhaus, M., Hoefsmit, E. C., Lanzavecchia, A. and Pieters, J., The mannose receptor functions as a high capacity and broad specificity antigen receptor in human dendritic cells. Eur. J. Immunol. 1997. 27: 2417-2425.
11. Freeman, M. W., Macrophages scavenger receptors. Curr. Opin. Immunol. 1994.5:143-148.
12. Gordon, S., Lawson, L., Rabinowitz, S., Crocker, P. R., Morris, L. and Perry, V. H., Antigen markers of macrophage differentiation in murine tissues. Curr. Top. Microbiol. Immunol. 1992. 181: 1-37.
13. Kovacsovics-Bankowski, M. and Rock, K. L., A phagosome to cytosol pathway for exogenous antigens presented on MHC Class I molecules. Science 1995. 267:243-246.
14. Drose, F. and Altendorf, K., Bafilomycin and concanamycins as inhibitors of V-ATPases and P-ATPases. J. Exp. Biol. 1997. 200: 1-8.
15. Wileman, T., Boshans, R. L., Schlesinger, P. and Stahl, P., Monensin inhibits recycling of macrophage mannoseglycoprotein receptors and ligand delivery to lysosomes. J. Biochem. 1984. 220: 665-675.
16. Rock, L. K., Gramm, C., Rothstein, L., Clark, K., Stein, R., Dick, L., Hwang, D. and Goldberg, A. L., Inhibitors of the proteosome block the degradation of most cell proteins and the generation of peptides on MHC Class I molecules. Cell 1994. 78: 761-771.
17. Fenteany, C., Standaert, R. F., Lane, W. S., Choi, S., Corey, E. J. and Schreiber, S. L., Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science 1995. 268: 726-731.
18. Apostolopoulos, V., Haurum, J. S. and McKenzie, I. F. C., MUC1 peptide epitopes associated with five different H-2 Class I molecules. Eur. J. Immunol. 1997. 27: 2579-2587.
19. Tilney, L. G. and Portnov, D. A., Actin filaments and the growth, movement and spread of the intracellular bacterial parasite, Listeria monocytogenes. J. Cell Biol. 1989.109:1597-1608.
20. Mounier, J., Ryter, A., Coquis-Rondon, M. and Sansonetti, P. J., Intracellular and cell-to-cell spread of Listeria monocytogenes involves interaction with F-actin in the enterocyte-like cell line Caco-2. Infect. Immun. 1990. 58:1048-1058.
21. Gao, X., Tite, J. P., Lipscombe, M., Rowland-Jones, S., Ferguson, J. and McMichael, A. J., Recombinant Salmonella typhimurium strains that invade non phagocytic cells are restricted to recognition by antigen specific cytotoxic T lymphocytes. Infect. Immun. 1992. 60:3780-3789.
22. Stover, C. K., de la Cruz, V. F., Fuerst, T. R. et al., New use of BCG for recombinant vaccines. Nature 1991. 351: 456-460.
23. Norbury, C. C., Hewlett, L. J., Prescott, A. R., Shastri, N. and Watts, C., Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages. Immunity 1995. 3: 783-791.
24. Oh, Y. K., Harding, C. V. and Swanson, J. A., The efficiency of antigen delivery from macrophage phagosomes into cytoplasm for MHC Class l-restricted antigen presentation. Vaccine 1997. 15:511-518.
25. Kovacsovics-Bankowski, M., Clark, K., Benacerraf, B. and Rock, K. L., Efficient major histocompatibility complex Class I presentation of exogenous antigen upon phagocytosis by macrophages. Proc. WarJ. Acad. Sei. USA 1993. 90: 4942-4946.
26. Rodriguez, A., Regnault, A., Kleijmeer, M., RicciardiCastagnoli, P. and Amigorena, S., Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells. Nature Cell Biol. 1999.1: 362-368.
27. Pontow, S. E., Kery, V. and Stahl, P. D., Mannose receptor. Int. Rev. Cytol. 1992.137B: 221-244.
28. Sallusto, F., Cella, M., Danieli, C. and Lanzavecchia, A., Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex Class II compartment: Down regulation by cytokines and bacterial products. J. Exp. Med. 1995.182: 389-400.
29. Prigozy, T. l., Sieling, P. A, Clemens, D., Stewart, P. L., Behar, S. M., Porcelli, M. B., Modlin, R. L. and Kronenberg, M., The mannose receptor delivers lipoglycan antigens to endosomes for presentation to T cells by CD1b molecules. Immunity 1997. 6: 187-197.
30. Suzuki, H., Kurihara, Y., Takeya, M., Kamada, N., Kataoka, M., Jishage, K., Ueda, O., Sakaguchi, H., Higashi, T., Suzuki, T. and Takashima, Y, A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature 1997. 386: 292-296.
31. Apostolopoulos, V., Barnes, N., Pietersz, G.A. and McKenzie, I.F.C., Ex vivo targeting of the macrophage mannose receptor for tumour immunotherapy. Vaccine 2000, in press.