DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: Immunogenicity in mice

Vaccine

Volumn 16, Issue 4, 1998, Pages 426-435

  Hanke, Tomáš ^a   Schneider, Jörg ^a   Gilbert, Sarah C ^b   Hill, Adrian V S ^a   McMichael, Andrew ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

DNA; Polyepitope; Vaccine

Indexed keywords

DNA VACCINE; EPITOPE; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; MALARIA VACCINE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MANUFACTURE; HUMAN IMMUNODEFICIENCY VIRUS; INTRAMUSCULAR DRUG ADMINISTRATION; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

EID: 0032007497     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(97)00296-X     Document Type: Article

References (41)

1. 1 McMichael, A. Cytotoxic T lymphocytes and immune surveillance. Cancer. Surv. 1992, 13, 5-21.
2. 2 Thomson, S.A., Khanna, R., Gardner, J., Burrows, S.R., Coupar, B., Moss, D.J. and Suhrbier, A. Minimal epitopes expressed in a recombinant polyepitope protein are processed and presented to CD8+ cytotoxic T cells: implications for vaccine design. Proc. Natl. Acad. Sci. USA 1995, 92, 5845-5849.
3. 3 Whitton, J.L., Sheng, N., Oldstone, M.B. and McKee, T.A. A 'string-of-beads' vaccine, comprising linked minigenes, confers protection from lethal-dose virus challenge. J. Virol. 1993, 67, 348-352.
4. 4 Lalvani, A., Aidoo, M., Allsopp, C.E., Plebanski, M., Whittle, H.C. and Hill, A.V. An HLA-based approach to the design of a CTL-inducing vaccine against Plasmodium falciparum. Res. Immunol. 1994, 145, 461-468.
5. 5 Sidney, J., Gray, H.M., Kubo, R.T. and Sette, A. Practical, biochemical and evolutionary implications of the discovery of HLA class I supermotifs. Immunol. Today 1996, 17, 261-266.
6. 6 Whalen, R.G., Leclerc, C., Deriaud, E., Schirmbeck, R., Reimann, J. and Davis, H.L. DNA-mediated immunization to the hepatitis B surface antigen. Activation and entrainment of the immune response. Ann. N.Y. Acad. Sci. 1995, 772, 64-76.
7. 7 Watanabe, A., Raz, E., Kohsaka, H., Tighe, H., Baird, S.M., Kipps, T.J. and Carson, D.A. Induction of antibodies to a kappa V region by gene immunization. J. Immunol. 1993, 151, 2871-2876.
8. 8 Ulmer, J.B., Donnelly, J.J., Parker, S.E., Rhodes, G.H., Felgner, P.L., Dwarki, V.J., Gromkowski, S.H., Deck, R.R., DeWitt, C.M., Friedman, A., Hawe, L.A., Leander, K.R., Martinez, D., Perry, H.C., Shiver, J.W., Montgomery, D.L. and Liu, M.A. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 1993, 259, 1745-1749.
9. 9 Xiang, Z. and Ertl, H.C. Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines. Immunity 1995, 2, 129-135.
10. 10 Raz, E., Carson, D.A., Parker, S.E., Parr, T.B., Abai, A.M., Aichinger, G., Gromkowski, S.H., Singh, M., Lew, D. and Yankauckas, M.A. et al. Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses. Proc. Natl. Acad. Sci. USA 1994, 91, 9519-9523.
11. 11 Manickan, E., Rouse, R.J., Yu, Z., Wire, W.S. and Rouse, B.T. Genetic immunization against herpes simplex virus. Protection is mediated by CD4+ T lymphocytes. J. Immunol. 1995, 155, 259-265.
12. 12 Tang, D.C., DeVit, M. and Johnston, S.A. Genetic immunization is a simple method for eliciting an immune response. Nature 1992, 356, 152-154.
13. 13 Krishnan, S., Haensler, J. and Meulien, P. Paving the way towards DNA vaccines. Nature Med. 1995, 1, 521-522.
14. 14 Fynan, E.F., Webster, R.G., Fuller, D.H., Haynes, J.R., Santoro, J.C. and Robinson, H.L. DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations. Proc. Natl. Acad. Sci. USA 1993, 90, 11478-11482.
15. 15 Davis, H.L., Schirmbeck, R., Reimann, J. and Whalen, R.G. DNA-mediated immunization in mice induces a potent MHC class I-restricted cytotoxic T-lymphocyte response to the hepatitis B envelope protein. Hum. Gene Ther. 1995, 6, 1447-1456.
16. 16 Kalams, S.A., Johnson, R.P., Trocha, A.K., Dynan, M.J., Ngo, H.S., D'Aquila, R.T., Kurnick, J.T. and Walker, B.D. Longitudinal analysis of TCR gene usage by HIV-1 envelope-specific CTL clones reveals a limited TCR repertoire. J. Exp. Med. 1994, 179, 1261-1271.
17. 17 Carmichael, A., Jin, X., Sissons, P. and Borysiewicz, L. Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1 )-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: differential CTL responses to HIV-1 and Epstein-Barr virus in late disease. J. Exp. Med. 1993, 177, 249-256.
18. 18 Plata, F., Autran, B., Martins, L.P., Wain-Hobson, S., Raphael, M., Mayaud, C., Denis, M., Guillon, J.M. and Debre, P. AIDS virus-specific cytotoxic T lymphocytes in lung disorders. Nature 1987, 328, 348-351.
19. 19 Walker, B.D., Chakrabarti, S., Moss, B., Paradis, T.J., Flynn, T., Durno, A.G., Blumberg, R.S., Kaplan, J.C., Hirsch, M.S. and Schooley, R.T. HIV-specific cytotoxic T lymphocytes in seropositive individuals. Nature 1987, 328, 345-348.
20. 20 Rowland-Jones, S.L., Nixon, D.F., Aldhous, M.C., Gotch, F., Ariyoshi, K., Hallam, N., Kroll, J.S., Froebel, K. and McMichael, A. HIV-specific cytotoxic T-cell activity in an HIV-exposed but uninfected infant. Lancet 1993, 341, 860-861.
21. 21 Rowland-Jones, S.L. and McMichael, A. Immune responses in HIV-exposed seronegatives: have they repelled the virus?. Curr. Opin. Immunol. 1995, 7, 448-455.
22. 22 Hill, A.V., Elvin, J., Willis, A.C., Aidoo, M., Allsopp, C.E., Gotch, F.M., Gao, X.M., Takiguchi, M., Greenwood, B.M. and Townsend, A.R. et al. Molecular analysis of the association of HLA-B53 and resistance to severe malaria. Nature 1992, 360, 434-439.
23. 23 Romero, P., Maryanski, J.L., Corradin, G., Nussenzweig, R.S., Nussenzweig, V. and Zavala, F. Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria. Nature 1989, 341, 323-326.
24. 24 Doolan, D.L., Khamboonruang, C., Beck, H.P., Houghten, R.A. and Good, M.F. Cytotoxic T-lymphocyte (CTL) low-responsiveness to the Plasmodium falciparum circumsporozoite protein in naturally-exposed endemic populations: analysis of human CTL response to most known variants. Int. Immunol. 1993, 5, 37-46.
25. 25 Rodrigues, M.M., Cordey, A.S., Arreaza, G., Corradin, G., Romero, P., Maryanski, J.L., Nussenzweig, R.S. and Zavala, F. CD8+ cytolytic T-cell clones derived against the Plasmodium yoelii circumsporozoite protein protect against malaria. Int. Immunol. 1991, 3, 579-585.
26. 26 Kunkel, T.A., Roberts, J.D. and Zakour, A. Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol. 1987, 154, 367-382.
27. 27 Graham, F.L. and van der Eb, A.J. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 1973, 52, 456-467.
28. 28 Seed, B. and Aruffo, A. Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure. Proc. Natl. Acad. Sci. USA 1987, 84, 3365-3369.
29. 29 Hanke, T., Szawlowski, P. and Randall, R.E. Construction of solid matrix-antibody-antigen complexes containing simian immunodeficiency virus p27 using tag-specific monoclonal antibody and tag-linked antigen. J. Gen. Virol. 1992, 73, 653-660.
30. 30 Davis, H.L., Demeneix, B.A., Quantin, B., Coulombe, J. and Whalen, R.G. Plasmid DNA is superior to viral vectors for direct gene transfer into adult mouse skeletal muscle. Hum. Gene. Ther. 1993, 4, 733-740.
31. 31 Miyahira, Y., Murata, K., Rodriguez, D.R.R.J., Esteban, M., Rodrigues, M.M. and Zavala, F. Quantification of antigen-specific CD8+ T cells using an ELISPOT assay. J. Immunol. Methods 1995, 181, 45-54.
32. 32 Kozak, M. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res. 1987, 15, 8125-8148.
33. 33 Takahashi, H., Nakagawa, Y., Yokomuro, K. and Berzofsky, J.A. Induction of CD8+ cytotoxic T lymphocytes by immunization with syngeneic irradiated HIV-1 envelope derived peptide-pulsed dendritic cells. Int. Immunol. 1993, 5, 849-857.
34. 34 Del Val, M., Schlicht, H., Rupert, T., Reddehase, M.J. and Koszinowski, U.H. Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein. Cell 1991, 66, 1145-1153.
35. 35 Hahn, Y.S., Braciale, V.L. and Braciale, T.J. Presentation of viral antigen to class I major histocompatibility complex-restricted cytotoxic T lymphocyte. Recognition of an immunodominant influenza hemaggluttnin site by cytotoxic T lymphocyte is independent of the position of the site in the hemagglutinin translation product. J. Exp. Med. 1991, 174, 733-736.
36. 36 Hahn, Y.S., Hahn, C.S., Braciale, V.L., Braciale, T.J. and Rice, C.M. CD8+ T cell recognition of an endogenously processed epitope is regulated primarily by residues within the epitope. J. Exp. Med. 1992, 176, 1335-1341.
37. 37 Chimini, G., Pala, P., Sire, J., Jordan, B.R. and Maryanski, J.L. Recognition of oligonucleotide-encoded T-cell eprtopes introduced into a gene unrelated to the original antigen. J. Exp. Med. 1989, 169, 297-302.
38. 38 Oldstone, M.B., Tishon, A., Eddleston, M., de, L.T.J., McKee, T. and Whitton, J.L. Vaccination to prevent persistent viral infection. J. Virol. 1993, 67, 4372-4378.
39. 39 Hanke, T., Botting, C., Green, E.A., Szawlowski, P.W., Rud, E. and Randall, R.E. Expression and purification of nonglycosylated SIV proteins, and their use in induction and detection of SIV-specific immune responses. AIDS Res. Hum. Retroviruses 1994, 10, 665-674.
40. 40 Hanke, T., Young, D.F., Doyle, C., Jones, I. and Randall, R.E. Attachment of an oligopeptide epitope to the C-terminus of recombinant SIV gp160 facilitates the construction of SMAA complexes while preserving CD4 binding. J. Virol. Methods 1995, 53, 149-156.
41. 41 Randall, R.E., Hanke, T., Young, D. and Southern, J.A. Two-tag purification of recombinant proteins for the construction of solid matrix-antibody-antigen (SMAA) complexes as vaccines. Vaccine 1993, 11, 1247-1252.