Increased phosphorylated extracellular signal-regulated kinase immunoreactivity associated with proliferative and morphologic lung alterations after chrysotile asbestos inhalation in mice

American Journal of Pathology

Volumn 156, Issue 4, 2000, Pages 1307-1316

  Robledo, R F ^a   Buder Hoffmann, S A ^a   Cummins, A B ^a   Walsh, E S ^a   Taatjes, D J ^a   Mossman, B T ^a  

^a UNIVERSITY OF VERMONT   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ASBESTOS; CHRYSOTILE; COMPLEMENTARY DNA; HYDROXYPROLINE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROCOLLAGEN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASBESTOSIS; CONTROLLED STUDY; ENZYME ACTIVATION; IMMUNOREACTIVITY; LUNG DISEASE; LUNG FIBROSIS; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL;

EID: 0033843374     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65001-8     Document Type: Article

References (42)

1. Dose-responsive increases in pulmonary fibrosis after inhalation of asbestos
2. Patterns of inflammation, cell proliferation, and related gene expression in lung after inhalation of chrysotile asbestos
3. Comparative proliferative and histopathologic changes in rat lungs after inhalation of chrysotile or crocidolite asbestos
4. Cell signaling pathways elicited by asbestos
5. The regulation of AP-1 activity by mitogen-activated protein kinases
6. Asbestos cause stimulation of the extracellular signal-related kinase 1 mitogen-activated protein kinase cascade after phosphorylation of the epidermal growth factor receptor
7. 2
8. Design, development, and test results of a horizontal flow facility
9. Expression of antioxidant enzymes in rat lungs after inhalation of asbestos or silica
10. Determinations of hydroxyproline in tissue and protein samples containing small proportions of the amino acid
11. 3H]-thymidine administered by injectionor osmotic pump
12. Chronic inhalation exposure of Wistar rats and two different strains of mice to diesel engine exhaust, carbon black, and titanium dioxide
13. Chronic effects on the respiratory tract of hamsters, mice and rats after long-term inhalation of high concentrations of filtered and unfiltered diesel engine emissions
14. Diesel exhaust is not a pulmonary carcinogen in CD-1 mice exposed under conditions carcinogenic to F344 rats
15. 1 expression in the lungs of inbred mice that fail to develop fibroproliferative lesions consequent to asbestos exposure
16. Incorporation of bromodeoxyuridine (BrdU) in the bronchiolar-alveolar regions of the lungs following two inhalation exposures to chrysotile asbestos in strain A/J mice
17. Bromodeoxyuridine (BrdU) uptake in the lungs of rats inhaling amosite asbestos or vitreous fibers at equal airborne fibre concentrations
18. TNF-α receptor knockout mice are protected from the fibroproliferative effects of inhaled asbestos fibers
19. Increased epidermal growth factor-receptor protein in a human mesothelial cell line in response to long asbestos fibers
20. Radiation-induced proliferation of the human A341 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation
21. Employment of the epidermal growth factor receptor in growth factor-independent signaling pathways
22. The detection of increased amounts of the extracellular domain of the epidermal growth factor receptor in serum during carcinogenesis in asbestosis patients
23. Up-regulated expression of transforming growth factor-α in the bronchiolar-alveolar duct regions of asbestos-exposed rats
24. Novel cell imaging techniques show induction of apoptosis and proliferation in mesothelial cells by asbestos
25. Asbestos-induced phosphorylation of the epidermal growth factor receptor (EGF-R) is linked causally to c-fos expression and apoptosis in mesothelial cells
26. Deposition pattern of inorganic particles at the alveolar level in the lungs of rats and mice
27. Chrysotile asbestos inhalation in rats: Deposition pattern and reaction of alveolar epithelium and pulmonary macrophages
28. Pathobiology of pulmonary fibrosis
29. Cellular and molecular mechanisms of asbestos-induced fibrosis
30. Upregulation of the PDGF-alpha receptor precedes asbestos-induced lung fibrosis in rats
31. Rapid activation of PDGF-A and PDGF-B expression at sites of lung injury in asbestos-exposed rats
32. 1, fibronectin, and smooth muscle actin in asbestos-induced pulmonary fibrosis in rats
33. Abundance of platelet-derived growth factors (PDGFs), PDGF receptors and activation of mitogen-activated protein kinases in brain decline with age
34. Transforming growth factor beta 1 rescues serum deprivation-induced apoptosis via the mitogen-activated protein kinase (MAPK) pathway in macrophages
35. Cooperativity between oxidants and tumor necrosis factor in the activation of nuclear factor (NF)-kappaB: Requirement of ras/mitogen-activated protein kinases in the activation of nf-kappa-b by oxidants
36. Both Erk and p38 kinases are necessary for cytokine gene transcription
37. Activation of extracellular signal-regulated kinase in lung tissues of mice treated with carcinogen
38. Dormant tumor-suppressor pathways in tumors
39. Raf-1 causes growth suppression and alteration of neuroendocrine markers in DMS53 human small-cell lung cancer cells
40. In situ visualization of intratumor growth factor signaling: Immunohisto-chemical localization of activated ERK/MAP kinase in glial neoplasms
41. Reversal of lung lesions in transgenic transforming growth factor α mice by expression of mutant epidermal growth factor receptor