Inhibition of HERG potassium channels by the antimalarial agent halofantrine

British Journal of Pharmacology

Volumn 130, Issue 8, 2000, Pages 1967-1975

  Tie, H ^a   Walker, B D ^a   Singleton, C B ^a   Valenzuela, S M ^a   Bursill, J A ^a   Wyse, K R ^a   Breit, S N ^b   Campbell, T J ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b ST VINCENT S HOSPITAL   (Australia)

Author keywords

Cardiac arrhythmia; Chinese hamster ovary (CHO K1) cells; Halofantrine; Human ether a go go related gene (HERG); QT prolongation

Indexed keywords

ANTIMALARIAL AGENT; HALOFANTRINE; POTASSIUM ION;

ANIMAL CELL; ANIMAL TISSUE; ANTIMALARIAL ACTIVITY; ARTICLE; BINDING KINETICS; CONTROLLED STUDY; LONG QT SYNDROME; MEMBRANE POTENTIAL; NONHUMAN; POTASSIUM TRANSPORT; PRIORITY JOURNAL; TORSADE DES POINTES; VOLTAGE CLAMP;

EID: 0033838649     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703470     Document Type: Article

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