Magnesium shifts voltage dependence of activation of delayed rectifier I(K) in guinea pig ventricular myocytes

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 272, Issue 3 41-3, 1997, Pages

  Williams, Beatrice A ^a   Beatch, Gregory N ^a,b  

^a Bureau of Drug Research   (Canada)

^b UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

Author keywords

class III antiarrhythmic drugs; potassium current; single cardiac myocytes; whole cell patch clamp

Indexed keywords

ANTIARRHYTHMIC AGENT; DOFETILIDE; ISOPRENALINE; MAGNESIUM ION; POTASSIUM ION;

ANIMAL CELL; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; GUINEA PIG; HEART ARRHYTHMIA; HEART MUSCLE CELL; HEART VENTRICLE WALL; ION CURRENT; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL;

EID: 0030898752     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1997.272.3.h1292     Document Type: Article

References (30)

1. 2+ channel activity in mammalian ventricular cells. Am. J. Physiol. 256 (Cell Physiol. 25): C452-C455, 1989.
2. 2+. Annu. Rev. Physiol. 53: 299-307, 1991.
3. + current in cardiac myocytes by dofetilide. J. Pharmacol. Exp. Ther. 262: 809-817, 1993.
4. Chinn, K. Two delayed rectifiers in guinea pig ventricular myocytes distinguished by tail current kinetics. J. Pharmacol. Exp. Ther. 264: 553-264, 1993.
5. Cohen, P. The structure and function of protein phosphatases. Annu. Rev. Biochem. 58: 453-508, 1989.
6. 2+. J. Physiol.(Lond.) 415: 251-274, 1989.
7. + current in frog atrial myocytes. J. Physiol.(Lond.) 435: 333-347, 1991.
8. 2+. Clin. Cardiol. 16: 768-774, 1993.
9. K, by cadmium in cat ventricular myocytes. Am. J. Physiol. 262 (Cell Physiol. 31): C75-C83, 1992.
10. + currents. J. Physiol. (Lond.) 368: 265-292, 1985.
11. 2+ ion in guinea pig atrial cells. Am. J. Physiol. 253 (Heart Circ. Physiol 22): H210-H214, 1987.
12. + channels in guinea-pig ventricular cells. J. Physiol. (Lond.) 387: 251-272, 1987.
13. + current by dofetilide. Circ. Res. 72: 75-83, 1993.
14. Ks) in canine ventricular epicardial, midmyocardial, and endocardial myocytes. Circ. Res. 76: 351-365, 1995.
15. Martell, A. E., and R. M. Smith. Critical Stability Constants. Amino Acids. New York: Plenum, 1974, vol. 1.
16. 2+. Nature 325: 156-159, 1987.
17. Matsuura, H., T. Ehara, and Y. Imoto. An analysis of the delayed outward current in single ventricular cells of the guinea-pig. Pflügers Arch. 410: 596-603, 1987.
18. + current in isolated membrane patches of guinea pig ventricular myocytes. Circ. Res. 74: 96-104, 1994.
19. Powell, T., D. A. Terrar, and V. W. Twist. Electrical properties of individual cells isolated from adult rat ventricular myocardium. J. Physiol. (Lond.) 302: 131-153, 1982.
20. + current. J. Gen. Physiol. 96: 195-215, 1990.
21. + currents. Pflügers Arch. 420: 180-186, 1991.
22. + channel block by a class III antiarrhythmic drug. J. Pharmacol. Exp. Ther. 276: 951-957, 1996.
23. K in single frog atrial cells. Am. J. Physiol. 257 (Heart Circ. Physiol. 26): H1663-H1669, 1989.
24. + current in guinea pig ventricular cells. Am. J. Physiol. 258 (Heart Circ. Physiol. 27) H1200-H1207, 1990.
25. 2+ ions. Proc. Natl. Acad. Sci. USA 84: 2560-2564, 1987.
26. Veldkamp, M. W., A. C. G. van Ginneken, T. Opthof, and L. N. Bouman. Delayed rectifier channels in human ventricular myocytes. Circulation 92: 3497-3504, 1995.
27. K by protein kinases A and C. Am. J. Physiol. 261 (Cell Physiol. 30): C1081-C1090, 1991.
28. 2+ current in isolated cardiac myocytes. Science 239: 778-780, 1988.
29. 2+ ions in cardiac function. Regulator of ion channels and second messengers. Biochem. Pharmacol. 38: 859-867, 1989.
30. 2+ on action potential duration in guinea pig ventricular myocytes. Am. J. Physiol. 268 (Heart Circ. Physiol. 37): H2321-H2328, 1995.