Antitumor imidazolyl disulfide IV-2 causes irreversible G2/M cell cycle arrest without hyperphosphorylation of cyclin-dependent kinase Cdk1

Journal of Pharmacology and Experimental Therapeutics

Volumn 294, Issue 3, 2000, Pages 1070-1075

  Vogt, A ^a   Tamura, K ^a   Watson, S ^a   Lazo, J S ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; IMIDAZOLE DERIVATIVE; THIOREDOXIN;

ANIMAL CELL; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CARCINOMA CELL; CELL CYCLE G2 PHASE; CELL STRAIN MCF 7; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; MITOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ALLYL COMPOUNDS; ANIMALS; ANTINEOPLASTIC AGENTS; CDC2 PROTEIN KINASE; DISULFIDES; G2 PHASE; HUMANS; IMIDAZOLES; MICE; MITOSIS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR CELLS, CULTURED;

EID: 0033838439     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Redox regulation of fos and jun DNA-binding activity in vitro
2. Bridge over troubled waters: Sensing stress by disulfide bond formation
3. Raf-1/bcl-2 phosphorylation: A step from microtubule damage to cell death
4. Form and function in protein dephosphorylation
5. Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: Evidence for a sulfenic acid intermediate and implications for redox regulation
6. The cdc25 protein contains an intrinsic phosphatase activity
7. Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase. Science (Wash CD)
8. Transfection with human thioredoxin increases cell proliferation and a dominant-negative mutant thioredoxin reverses the transformed phenotype of human breast cancer cells
9. Cell growth stimulation by the redox protein thioredoxin occurs by a novel helper mechanism
10. Proof that the endogenous, heat-stable glucocorticoid receptor-activating factor is thioredoxin
11. Thioredoxin
12. Dephosphorylation of human p34cdc2 kinase on both Thr-14 and Tyr- 15 by human cdc25B phosphatase
13. Possible regulation of the in vitro assembly of bovine brain tubulin by the bovine thioredoxin system
14. Redox active disulfides: The thioredoxin system as a drug target
15. Synthesis and evaluation of imidazolyl disulfides for selective cytotoxicity to hypoxic EMT6 tumor cells in vitro
16. Mechanisms of inhibition of the thioredoxin growth factor system by antitumor 2-imidazolyl disulfides
17. Parallel syntheses of disulfide inhibitors of the thioredoxin redox system as potential antitumor agents
18. Depressed p34cdc2 kinase activity and G2/M phase arrest induced by diallyl disulfide in HCT-15 cells
19. Enzymatic synthesis of deoxyribanucleotides. IV. Isolation and characterization of thioredoxin, the hydrogen donor from Escherichia coli B
20. cdc25 + encodes a protein phosphatase that dephosphorylates p34cdc2
21. Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor
22. Superoxide dismutase and thioredoxin restore defective p34cdc2 kinase activation in mouse two-cell block
23. Thioredoxin redox signalling: A novel target for anti-cancer drug development
24. Active site titration of the tyrosine phosphatases SHP-1 and PTP1B using aromatic disulfides Reaction with the essential cysteine residue in the active site
25. A targeted library of small-molecule, tyrosine, and dual-specificity phosphatase inhibitors derived from a rational core design and random side chain variation
26. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
27. Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25
28. Novel anti-carcinogenic activity of an organosulfide from garlic: Inhibition of H-RAS oncogene transformed tumor growth in vivo by diallyl disulfide is associated with inhibition of p21H-ras processing
29. Dual G1 and G2/M phase inhibition by SC-alpha alpha delta 9, a combinatorially derived Cdc25 phosphatase inhibitor
30. Cdc25 inhibition and cell cycle arrest by a synthetic thioalkyl vitamin K analogue
31. The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product
32. Disruption of insulin-like growth factor-1 signaling and down-regulation of cdc2 by SC-ααδ 9, a novel small molecule antisignaling agent identified in a targeted array library