Disruption of insulin-like growth factor-1 signaling and down-regulation of Cdc2 by SC-ααδ9, a novel small molecule antisignaling agent identified in a targeted array library

Journal of Pharmacology and Experimental Therapeutics

Volumn 287, Issue 2, 1998, Pages 806-813

  Vogt, Andreas ^a   Rice, Robert L ^a   Settineri, Catherine E ^a   Yokokawa, Fumiaki ^b   Yokokawa, Shiho ^b   Wipf, Peter ^b,c   Lazo, John S ^a,c  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [BENZYL [2 [(2,5 DIPHENYLOXAZOLE 4 CARBONYL)AMINO]ETHYL]CARBAMOYL 2 DECANOYLAMINO BUTYRIC ACID; BUTYRIC ACID DERIVATIVE; OKADAIC ACID; PHOSPHATASE; SOMATOMEDIN C; UNCLASSIFIED DRUG; VANADIC ACID;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; AUTOCRINE EFFECT; CELL PROLIFERATION; CELL SURVIVAL; CYTOTOXICITY; DRUG SYNTHESIS; EMBRYO; ENZYME ACTIVITY; ENZYME ASSAY; FETUS; FIBROBLAST; GENE OVEREXPRESSION; MITOSIS INHIBITION; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SIMIAN VIRUS 40; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; VIROGENESIS; VIRUS INHIBITION;

ANIMALS; CDC2 PROTEIN KINASE; CDC25 PHOSPHATASE; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE; CELL TRANSFORMATION, VIRAL; DOWN-REGULATION; ENZYME INHIBITORS; FEMALE; INSULIN-LIKE GROWTH FACTOR I; MICE; OKADAIC ACID; OXAZOLES; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; PREGNANCY; RECEPTOR, IGF TYPE 1; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE; VANADATES;

EID: 0032469399     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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