A short sequence within two purine-rich enhancers determines 5' splice site specificity

Molecular and Cellular Biology

Volumn 18, Issue 1, 1998, Pages 343-352

  Elrick, Leslie L ^a   Humphrey, Mary Beth ^a   Cooper, Thomas A ^a   Berget, Susan M ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALDESMON; MESSENGER RNA PRECURSOR; NUCLEOTIDE; PURINE; RNA; TROPONIN T;

ARTICLE; ENHANCER REGION; EXON; GENE; HUMAN; MUTATION; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING;

GALLUS GALLUS;

EID: 2642660440     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.1.343     Document Type: Article

References (44)

1. Amendt, B. A., Z. H. Si, and C. M. Stoltzfus. 1995. Presence of exon splicing silencers within human immunodeficiency virus type 1 tat exon 2 and tat-rev exon 3: evidence for inhibition mediated by cellular factors. Mol. Cell. Biol. 15:4606-4615.
2. Black, D. L. 1995. Finding splice sites within a wilderness of RNA. RNA 1:763-771.
3. Caceres, J. F., S. Stamm, D. M. Helfman, and A. R. Krainer. 1994. Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. Science 265:1706-1709.
4. Caputi, M., G. Casari, S. Guenz, R. Tagliabue, A. Sidoli, C. A. Melo, and F. E. Baralle. 1994. A novel bipartite splicing enhancer modulates the differential processing of the human fibronectin EDA exon. Nucleic Acids Res. 22:1018-1022.
5. Cooper, T. A. 1992. In vitro splicing of cardiac troponin T precursors - exon mutations disrupt splicing of the upstream intron. J. Biol. Chem. 267:5330-5338.
6. Cooper, T. A., and C. P. Ordahl. 1989. Nucleotide substitutions within the cardiac troponin T alternative exon disrupt pre-mRNA alternative splicing. Nucleic Acids Res. 17:7905-7921.
7. Crispino, J. D., B. J. Blencowe, and P. A. Sharp. 1994. Complementation by SR proteins of pre-mRNA splicing reactions depleted of U1 snRNP. Science 265:1866-1869.
8. Dirksen, W. P., R. K. Hampson, S. Qiang, and F. M. Rottman. 1994. A purine-rich exon sequence enhances alternative splicing of bovine growth hormone pre-mRNA. J. Biol. Chem. 269:6431-6436.
9. Dominski, Z., and R. Kole. 1994. Identification of exon sequences involved in splice site selection. J. Biol. Chem. 269:23590-23596.
10. Fu, X.-D. 1993. The superfamily of arginine/serine-rich splicing factors. RNA 1:663-680.
11. Gamberi, C., E. Izurralde, C. Beisel, and I. W. Mattaj. 1997. Interaction between the human nuclear cap-binding protein complex and hnRNP F. Mol. Cell. Biol. 17:2575-2597.
12. Hayashi, K., H. Yano, T. Hashida, R. Takeuchi, O. Takeda, K. Asada, E. Takahashi, I. Kato, and K. Sobue. 1942. Genomic structure of the human caldesmon gene. Proc. Natl. Acad. Sci. USA 89:12122-12126.
13. Hedley, M. L., and T. Maniatis. 1991. Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro. Cell 65:579-586.
14. Hodges, D., and S. I. Bernstein. 1994. Genetic and biochemical analysis of alternative splicing. Adv. Genet. 31:207-281.
15. Humphrey, M. B., J. Bryan, T. A. Cooper, and S. M. Berget. 1995. A 32-nucleotide exon-splicing enhancer regulates usage of competing 5′ splice sites in a differential internal exon. Mol. Cell. Biol. 15:3979-3988.
16. Humphrey, M. B., and J. Bryan. 1992. Human caldesmon isoforms are generated by an unusual alternative splicing mechanism, abstr. 234. In Abstracts of the American Society of Cell Biology Thirty-Second Annual Meeting. American Society of Cell Biology, Bethesda, Md.
17. Humphrey, M. B., H. Herrera-Sosa, G. Gonzalez, R. Lee, and J. Bryan. 1992. Cloning of cDNAs encoding human caldesmons. Gene 112:197-204.
18. Kanopka, A., O. Muhlemann, and G. Akusjarvi. 1996. Inhibition by SR proteins of splicing of a regulated adenovirus pre-mRNA. Nature 381:535-538.
19. Kohtz, J. D., S. F. Jamison, C. L. Will, P. Zuo, R. Luhrmann, M. A. Garcia-Blanco, and J. L. Manley. 1994. Protein-protein interactions and 5′ splice site recognition in mammalian mRNA precursors. Nature 368:119-124.
20. Lavigueur, A., H. La Branche, A. R. Kornblihtt, and B. Chabot. 1993. A splicing enhancer in the human fibronectin alternate ED1 exon interacts with S/R proteins and stimulates U2 snRNP binding. Genes Dev. 7:2405-2417.
21. Lou, H., R. F. Gagel, and S. M. Berget. 1996. An intron enhancer recognized by splicing factors activates polyadenylation. Genes Dev. 10:208-219.
22. Lynch, K. W., and T. Maniatis. 1995. Synergistic interactions between two distinct elements of a regulated splicing enhancer. Genes Dev. 9:284-293.
23. Lynch, K. W., and T. Maniatis. 1995. Synergistic interactions between two distinct elements of a regulated splicing enhancer. Genes Dev. 9:284-293.
24. Manley, J. L., and R. Tacke. 1996. SR proteins and splicing control. Genes Dev. 10:1569-1579.
25. Ramchatesingh, J., A. M. Zahler, K. M. Neugebauer, M. B. Roth, and T. Cooper. 1995. A subset of S/R proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer. Mol. Cell. Biol. 15:4898-4907.
26. Reed, R. 1996. Initial splice-site recognition and pairing during pre-mRNA splicing. Curr. Opin. Genet. Dev. 6:215-220.
27. Robberson, B. L., G. J. Cote, and S. M. Berget. 1990. Exon definition may facilitate splice site selection in RNAs with multiple exons. Mol. Cell. Biol. 10:84-94.
28. Ryner, L. C., S. F. Goodwin, D. H. Castrillon, A. Anand, A. Villella, B. S. Baker, J. C. Hall, B. J. Taylor, and S. A. Wasserman. 1990. Control of male sexual orientation in Drosophila by the fruitless gene. Cell 87:1079-1090.
29. Screaton, G. R., J. F. Caceres, A. Mayeda, M. V. Bell, M. Plebanski, D. G. Jackson, J. I. Bell, and A. R. Krainer. 1995. Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. EMBO J. 14:4336-4349.
30. Staffa, A., and A. Cochrane. 1995. Identification of positive and negative splicing regulatory elements within the terminal tat-rev exon of human immunodeficiency virus type 1. Mol. Cell. Biol. 15:4597-4605.
31. Staknis, D., and R. Reed. 1994. S/R proteins promote the first specific recognition of pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex. Mol. Cell. Biol. 14:7670-7682.
32. Sun, Q., A. Mayeda, R. K. Hampson, A. R. Krainer, and F. M. Rottman. 1993. General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer. Genes Dev. 7:2598-2608.
33. Tacke, R., and J. L. Manley. 1995. The human splicing factors ASF/SF2 and SC35 possess distinct, functionally significant RNA binding specificities. EMBO J. 14:3540-3551.
34. Tacke, R., and J. L. Manley. 1997. Sequence-specific binding by an SR protein requires RS domain phosphorylation: creation of an SRp40-specific splicing enhancer. Proc. Natl. Acad. Sci. USA 94:1148-1153.
35. Talerico, M., and S. M. Berget. 1990. Effect of 5′ splice site mutations on splicing of the preceding intron. Mol. Cell. Biol. 10:6299-6305.
36. Tanaka, K., A. Watakabe, and Y. Shimura. 1994. Polypurine sequences within a downstream exon function as a splicing enhancer. Mol. Cell. Biol. 4:1347-1354.
37. Tarn, W. Y., and J. A. Steitz. 1994. SR protein can compensate for the loss of U1 snRNP function in vitro. Genes Dev. 8:2704-2717.
38. van Oers, C. C. M., G. J. Adema, H. Zandberg, T. C. Moen, and P. D. Baas. 1994. Two different sequence elements within exon 4 are necessary for calcitonin-specific splicing of the human calcitonin/calcitonin gene-related peptide I pre-mRNA. Mol. Cell. Biol. 14:951-960.
39. Wang, J., and J. L. Manley. 1995. Overexpression of the S/R proteins ASF/ SF2 and SC35 influences alternative splicing in vivo in diverse ways. RNA 1:335-346.
40. Wang, J., Y. Takagaki, and J. L. Manley. 1996. Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability. Genes Dev. 10:2588-2599.
41. Watakabe, A., K. Tanaka, and Y. Shimura. 1993. The role of exon sequences in splice site selection. Genes Dev. 7:407-418.
42. Xu, R., J. Teng, and T. A. Cooper. 1993. The cardiac troponin T alternative exon contains a novel purine-rich positive splicing element. Mol. Cell. Biol. 13:3660-3674.
43. Yeakley, J. M., F. Hedjran, J.-P. Morfin, N. Merillat, M. G. Rosenfeld, and R. B. Emerson. 1993. Control of calcitonin/calcitonin gene-related peptide pre-mRNA processing by constitutive exon and intron elements. Mol. Cell. Biol. 13:5999-6011.
44. Zahler, A. M., W. S. Lane, J. A. Stolk, and M. B. Roth. 1992. S/R proteins - a conserved family of pre-messenger-RNA splicing factors. Genes Dev. 6:837-847.