A highly stable duplex structure sequesters the 5′ splice site region of hnRNP A1 alternative exon 7B

RNA

Volumn 3, Issue 4, 1997, Pages 405-419

  Blanchette, Marco ^a   Chabot, Benoit ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

Author keywords

RNA structure; Splice site selection; Splicing; U1 snRNP

Indexed keywords

HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; MESSENGER RNA PRECURSOR; RIBONUCLEASE H;

ALTERNATIVE RNA SPLICING; ARTICLE; BASE PAIRING; CONTROLLED STUDY; EXON; HELA CELL; HUMAN; HUMAN CELL; INTRON; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; RNA STRUCTURE;

ALTERNATIVE SPLICING; ANIMALS; BASE SEQUENCE; CELL NUCLEUS; CONSERVED SEQUENCE; EVOLUTION; EXONS; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN GROUP A-B; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; INTRONS; MICE; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; RIBONUCLEASE H, CALF THYMUS; RIBONUCLEOPROTEIN, U1 SMALL NUCLEAR; RIBONUCLEOPROTEINS; RNA PRECURSORS; RNA, MESSENGER; SEQUENCE HOMOLOGY, NUCLEIC ACID; SPECIES SPECIFICITY; SUBCELLULAR FRACTIONS;

MURINAE;

EID: 0030961869     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Ben-David Y, Bani MR, Chabot B, De Koven A, Bernstein A. 1992. Retroviral insertions downstream of the heterogeneous nuclear ribonucleoprotein A1 gene in erythroleukemia cells: Evidence that A1 is not essential for cell growth. Mol Cell Biol 12:4449-4455.
2. Biamonti G, Buvoli M, Bassi MT, Morandi C, Cobianchi F, Riva S. 1989. Isolation of an active gene encoding human hnRNP protein A1. Evidence for alternative splicing. J Mol Biol 207:491-503.
3. Black DL. 1995. Finding splice sites within a wilderness of RNA. RNA 1:763-771.
4. Burd CG, Dreyfuss G. 1994. RNA binding specificity of hnRNP A1: Significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing. EMBO J 33:1197-1204.
5. Buvoli M, Cobianchi F, Bestagno MG, Mangiarotti A, Bassi MT, Biamonti G, Riva S. 1990. Alternative splicing in the human gene for the core protein A1 generates another hnRNP protein. EMBO J 9:1229-1235.
6. Cáceres JF, Stamm S, Helfman DM, Krainer AR. 1994. Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. Science 265:1706-1709.
7. Chabot B. 1994. Synthesis and purification of RNA substrates. In: Higgins SJ, Hames BD, eds. RNA processing, vol I. Oxford, Oxford University Press.
8. Chabot B. 1996. Directing alternative splicing: Cast and scenarios. Trends Genet 12:472-478.
9. Chabot B, Blanchette M, Lapierre I, La Branche H. 1997. An intron element modulating 5′ splice site selection in the hnRNP A1 pre-mRNA interacts with hnRNP A1. Mol Cell biol. Forthcoming.
10. Chabot B, Steitz JA. 1987. Multiple interactions between the splicing substrate and small nuclear ribonucleoproteins in spliceosomes. Mol Cell Biol 7:281-293.
11. Charpentier B, Rosbash M. 1996. Intramolecular structure in yeast introns aids the early steps of in vitro spliceosome assembly. RNA 2:509-522.
12. Chebli K, Gattoni R, Schmitt P, Hildwein G, Stevenin J. 1989. The 216-nucleotide intron of the E1A pre-mRNA contains a hairpin structure that permits utilization of unusually distant branch acceptors. Mol Cell Biol 9:4852-4861.
13. Clouet d'Orval B, d'Aubenton-Carafa Y, Marie J, Brody E. 1991a. Determination of an RNA structure involved in splicing inhibition of a muscle-specific exon. J Mol Biol 221:837-856.
14. Clouet d'Orval B, d'Aubenton-Carafa Y, Sirand-Pugnet P, Brody E, Marie J. 1991b. RNA secondary structure represses utilization of a muscle-specific exon in HeLa cell nuclear extracts. Science 252:1823-1828.
15. Deshler JO, Rossi JJ. 1991. Unexpected point mutations activate cryptic 3′ splice sites by perturbing a natural secondary structure within a yeast intron. Genes & Dev 5:1252-1263.
16. Dignam JD, Lebovitz RM, Roeder RG. 1992. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11:1475-1489.
17. Domenjoud L, Gallinaro H, Kister L, Meyer S, Jacob M. 1991. Identification of a specific exon sequence that is a major determinant in the selection between a natural and a cryptic 5′ splice site. Mol Cell Biol 33:4581-4590.
18. Eng FJ, Warner JR. 1991. Structural basis for the regulation of splicing of a yeast messenger RNA. Cell 65:797-804.
19. Eperon IC, Ireland DC, Smith RA, Mayeda A, Krainer AR. 1993. Pathways for selection of 5′ splice sites by U1 snRNPs and SF2/ ASF. EMBO J 12:3607-3617.
20. Eperon LP, Estibeiro JP, Eperon IC. 1986. The role of nucleotide sequences in splice site selection in eukaryotic pre-messenger RNA. Nature 324:280-282.
21. Eperon LP, Graham IR, Griffiths AD, Eperon IC. 1988. Effects of RNA secondary structure on alternative splicing of pre-mRNA: Is folding limited to a region behind the transcribing RNA polymerase? Cell 54:393-401.
22. Fu XD. 1995. The superfamily of arginine/serine-rich splicing factors. RNA 1:663-680.
23. Fu XY, Colgan JD, Manley JL. 1988. Multiple cis-acting sequence elements are required for efficient splicing of simian virus 40 small-t antigen pre-mRNA. Mol Cell Biol 3:3582-3590.
24. Goguel V, Rosbash M. 1993. Splice site choice and splicing efficiency are positively influenced by pre-mRNA intramolecular base pairing in yeast. Cell 72:893-901.
25. Goguel V, Wang Y, Rosbach M. 1993. Short artificial hairpins sequester splicing signals and inhibit yeast pre-mRNA splicing. Mol Cell Biol 13:6841-6848.
26. Kister L, Domenjoud L, Gallinaro H, Jacob M. 1993. A cis-acting selector of a 5′ splice site. J Biol Chem 268:21955-21961.
27. Kohtz JD, Jamison SF, Will CL, Zuo P, Lührmann R, Garcia-Blanco MA, Manley JL. 1994. Protein-protein interactions and 5′-splice-site recognition in mammalian mRNA precursors. Nature 368:119-124.
28. Krainer AR, Maniatis T. 1985. Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro. Cell 42:725-736.
29. Lavigueur A, La Branche H, Kornblihtt AR, Chabot B. 1993. A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding. Genes & Dev 7:2405-2417.
30. Libri D, Balvay L, Fizman MY. 1992. In vivo splicing of the β tropomyosin pre-mRNA: A role for branch point and donor site competition. Mol Cell Biol 12:3204-3215.
31. Libri D, Stutz F, McCarthy T, Rosbach M. 1995. RNA structural patterns and splicing: Molecular basis for an RNA-based enhancer. RNA 1:425-436.
32. Lin CH, Patton JG. 1995. Regulation of alternative 3′ splice site selection by constitutive splicing factors. RNA 1:234-245.
33. Liu HX, Goodall GJ, Kole R, Filipowicz W. 1995. Effects of secondary structure on pre-mRNA splicing: Hairpins sequestering the 5′ but not the 3′ splice site inhibit intron processing in Nicotiana plumbaginifolia. EMBO J 14:377-388.
34. Manley JL, Tacke R. 1996. SR proteins and splicing control. Genes & Dev 10:1569-1579.
35. Mayeda A, Krainer AR. 1992. Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. Cell 68:365-375.
36. Mayeda A, Munroe SM, Caceres JF, Krainer AR. 1994. Function of conserved domains of hnRNP A1 and other hnRNP A/B proteins. EMBO J 13:5483-5495.
37. Newman A. 1987. Specific accessory sequences in Saccharomyces cerevisiae introns control assembly of pre-mRNAs into spliceosomes. EMBO J 6:3833-3839.
38. Reed R. 1996. Initial splice-site recognition and pairing during pre-mRNA splicing. Curr Opin Genet Dev 6:215-220.
39. Robberson BL, Cote GJ, Berget SM. 1990. Exon definition may facilitate splice site selection in RNAs with multiple exons. Mol Cell Biol 10:84-94.
40. Siebel CW, Admon A, Rio DC. 1995. Soma-specific expression and cloning of PSI, a negative regulator of P element pre-mRNA splicing. Genes & Dev 9:269-283.
41. Siebel CW, Kanaar R, Rio DC. 1994. Regulation of tissue-specific P-element pre-mRNA splicing requires the RNA-binding protein PSI. Genes & Dev 8:1713-1725.
42. Sirand-Pugnet P, Durosay P, Clouet d'Orval B, Brody E, Marie J. 1995. β-Tropomysosin pre-mRNA folding around a muscle-specific exon interferes with several steps of spliceosome assembly. J Mol Biol 251:591-602.
43. Solnick D. 1985. Alternative splicing caused by RNA secondary structure. Cell 43:667-676.
44. Solnick D, Lee SI. 1987. Amount of RNA secondary structure required to induce an alternative splice. Mol Cell Biol 7:3194-3198.
45. Valcárcel J, Singh R, Zamore PD, Green MR. 1993. The protein Sexlethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA. Nature 362:171-175.
46. Vilardell J, Warner JR. 1994. Regulation of splicing at an intermediate step in the formation of the spliceosome. Genes & Dev 8:211-220.
47. Wang Z, Hoffmann HM, Grabowski PJ. 1995. Intrinsic U2AF binding is modulated by exon enhancer signals in parallel with changes in splicing activity. RNA 1:21-35.
48. Wu JY, Maniatis T. 1993. Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. Cell 75:1061-1070.
49. B proteins of heterogeneous nuclear ribonucleparticles modulate 5′ splice site selection in vivo. Proc Natl Acad Sci USA 91:6924-6928.
50. 35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing. Genes & Dev 10:1356-1368.