MDL 101,002, a free radical spin trap, is efficacious in permanent and transient focal ischemia models

Life Sciences

Volumn 63, Issue 4, 1998, Pages 241-253

  Johnson, Michael P ^b   McCarty, Debbie R ^b   Velayo, Nelson L ^a   Markgraf, Carrie G ^c   Chmielewski, Paula A ^d   Ficorilli, James V ^b   Cheng, Hsien C ^a   Thomas, Craig E ^b  

^a SANOFI   (France)

^b ELI LILLY AND COMPANY   (United States)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^d PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

Antioxidants; Free radicals; MDL 101,002; Neuroprotection; Transient cerebral ischemia

Indexed keywords

3,4 DIHYDRO 3,3 DIMETHYLISOQUINOLINE N OXIDE; FREE RADICAL; NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BODY TEMPERATURE; BRAIN INFARCTION; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; INTRAVENOUS DRUG ADMINISTRATION; NEUROPROTECTION; NONHUMAN; RAT;

ANIMALS; BODY TEMPERATURE; BRAIN ISCHEMIA; FREE RADICAL SCAVENGERS; ISOQUINOLINES; NEUROPROTECTIVE AGENTS; NITROGEN OXIDES; RATS; RATS, INBRED SHR; RATS, WISTAR; SPIN LABELS;

ANIMALIA; RATTUS NORVEGICUS;

EID: 18144440399     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(98)00268-9     Document Type: Article

References (42)

1. 1. H.Y. KIL, J. ZHANG AND C. PIANTADOSI, J. Cerebral Bl. Flow Metab. 16 100-106 (1996).
2. 2. E. LANCELOT, J. CALLEBERT, M.-L. REVAUD, R.G. BOULU AND M. PLOTKINE, Neurosci. Let. 197 85-88 (1995).
3. 3. E. HALL, P. ANDRUS AND P. YONKERS, J. Neurochem. 60 588-594 (1993).
4. 4. B.D. WATSON, R. BUSTO, W.J. GOLDBERG, M. SANTISO, S. YOSHIDA AND M.D. GINSBERG, J. Neurochem. 42 268-274 (1984).
5. 5. B.D. WATSON (Ed.), Evaluation of the concomitance of lipid peroxidation in experimental models of cerebral ischemia and stroke, Vol. 96, Elsevier Science Publishers, Amsterdam (1993).
6. 6. H.S. MICKEL, Y.N. VAISHNAV, O. KEMPSKI, D. VON LUBITZ, J.F. WEISS AND G. FEUERSTEIN, Stroke 18 426-430 (1987).
7. 7. C.N. OLIVER, P.E. STARKE-REED, E.R. STADTMAN, G.J. LIU, J.M. CARNEY AND R.A. FLOYD, Proc. Nat. Acad. Sci. 87 5144-5147 (1990).
8. 8. S.P. MAHADIK, V.A. BHARUCHA, A. STADLIN, A. ORTIZ AND S.E. KARPIAK, J. Neurosci. Res. 32 209-220 (1992).
9. 9. C.E. THOMAS AND D.J. REED, Arch. Biochem. Biophys. 281 96-105 (1990).
10. 10. E.D. HALL, P.K. ANDRUS, J.S. ALTHAUS AND P.F. VONVOIGTLANDER, J. Neurosci. Res. 34 107-112 (1993).
11. 11. J.M. BRAUGHLER AND E.D. HALL, J. Neurotrauma 9 (suppl 1) S1-S7 (1992).
12. 12. H. HARA, H. KATO AND K. KOGURE, Brain Res. 510 335-338 (1990).
13. 13. C. WILLY, J. THIERY, M. MENGER, K. MESSMER, K.E. ARFORS AND H.-A. LEHR, Free Rad. Biol. Med. 19 919-926 (1995).
14. 14. S. YOSHIDA, R. BUSTO, B.D. WATSON, M. SANTISO AND M.D. GINSBERG, J. Neurochem. 44 1593-1601 (1985).
15. 15. J.W. PHILLIS AND C. CLOUGH-HELFMAN, Med. Sci. Res. 18 403 (1990).
16. 16. T.-L. YUE, J.-L. GU, P.G. LYSKO, H.-Y. CHENG, F. BARONE AND G. FEUERSTEIN, Brain Res. 574 193-197 (1992).
17. 17. X. CAO AND J. W. PHILLIS, Brain Res. 644 267-272 (1994).
18. 18. Q. ZHAO, K. PAHLMARK, M.-L. SMITH AND B.K. SIESJO, Acta Physiol. Scand. 152 349-350 (1994).
19. 19. J. FOLBERGROVÁ, Q. ZHAO, K.-I. KATSURA AND B.K. SIESJÖ, Proc. Nat. Acad. Sci. 92 5057-5061 (1995).
20. 20. D.E. ANDERSON, X.-J. YUAN, C.-M. TSENG, L. RUBIN, G.M. ROSEN AND M.L. TOD, Biochem. Biophys. Res. Com. 193 878-885 (1993).
21. 21. O. INANAMI AND M. KUWABARA, Free Rad. Res. 23 33-39 (1995).
22. 22. J.F. FRENCH, C.E. THOMAS, T.R. DOWNS, D.F. OHLWEILER, A.A. CARR AND R.C. DAGE, Circul. Shock 43 130-136 (1994).
23. 23. C.E. THOMAS, D.F. OHLWEILER AND B. KALYANARAMAN, J. Biol. Chem. 269 28055-28061 (1994).
24. 24. C.E. THOMAS, D.F. OHLWEILER, A.A. CARR, T.R. NIEDUZAK, D.A. HAY, G. ADAMS, R. VAZ AND R.C. BERNOTAS, J. Biol. Chem. 271 3097-3104 (1996).
25. 25. C.E. THOMAS, D.F. OHLWEILER, V.L. TAYLOR AND C.J. SCHMIDT, J. Neurochem. 68 1173-1182 (1997).
26. 26. P. COYLE, Stroke 13 855-859 (1982).
27. 27. S. BRINT, M. JACEWICZ, M. KIESSLING, J. TANABE AND W. PULSINELLI, J. Cerebral Bl. Flow Metab. 8 474-485 (1988).
28. 28. A.M. BUCHAN, D. XUE AND A. SLIVKA, Stroke 23 273-279 (1992).
29. 29. E. ZEA LONG, P.R. WEINSTEIN, S. CARLSON AND R. CUMMINS, Stroke 20 84-91 (1989).
30. 30. L. BELAYEV, R. BUSTO, W. ZHAO AND M.D. GINSBERG, Stroke 26 2313-2319 (1995).
31. 31. J.B. BEDERSON, L.H. PITTS, S.M. GERMANO, M.C. NISHIMURA, R.L. DAVIS AND H.M. BARTKOWSKI, Stroke 17 1304-1308 (1986).
32. 32. S.T. CHEN, C. HSU, E. HOGAN, H. MARICQ AND J.D. BALENTINE, Stroke 17 738-743 (1986).
33. 33. Q. ZHAO, H. MENEZAWA, M.-L. SMITH AND B.K. SIESJÖ, Brain Res. 649 253-259 (1994).
34. 34. H. MEMEZAWA, Q. ZHAO, M.-L. SMITH AND B. SIESJÖ, Brain Res. 670 48-52 (1995).
35. 35. A. SAKAMOTO, S.T. OHNISHI, T. OHNISHI AND R. OGAWA, Brain Res. 554 186-192 (1991).
36. 36. A. SAKAMOTO, S.T. OHNISHI, T. OHNISHI AND R. OGAWA, Trapping of oxygen free radicals during brain ischemia and reperfusion, S.T. OHNISHI AND T. OHNISHI (Eds), 445-453, CRC Press, New York (1995).
37. 37. R. BUSTO, W.D. DIETRICH, M.Y.-T. GLOBUS, I. VALDÉS, P. SCHEINBERG AND M.D. GINSBERG, J. Cerebral Bl. Flow Metab. 7 729-738 (1987).
38. 38. F. BARONE, G. FEUERSTEIN AND R. WHITE, Neurosci. Biobeh. Rev. 21 31-44 (1997).
39. 39. R.A. FLOYD, Adv. Pharmacol. 38 361-379 (1997).
40. 40. T. MIYAJIMA AND Y. KOTAKE, Biochem. Biophys. Res. Com. 215 114-121 (1995).
41. 41. T.R. DOWNS, R.C. DAGE AND J.F. FRENCH, Int. J. Immunopharmacol. 17 571-580 (1995).
42. 42. J.A. CLEMENS, D.T. STEPHENSON, T. YIN, E.B. SMALSTIG, J.A. PANETTE AND S.P. LITTLE, Stroke 29 677-682 (1998).