Lack of correlation between the α-tocopherol content of plasma and LDL, but high correlations for γ-tocopherol and carotenoids

Journal of Lipid Research

Volumn 37, Issue 9, 1996, Pages 1936-1946

  Ziouzenkova, Ouliana ^a   Winklhofer Roob, Brigitte M ^b   Puhl, Herbert ^a   Roob, Johannes M ^a   Esterbauer, Hermann ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

tocopherol; carotene; carotenoids; low density lipoprotein; plasma; vitamin E

Indexed keywords

ALPHA CAROTENE; ALPHA TOCOPHEROL; ANTIOXIDANT; BETA CAROTENE; CANTHAXANTHIN; CAROTENOID; CHOLESTEROL; CHOLESTEROL ESTER; CRYPTOXANTHIN; GAMMA TOCOPHEROL; LIPID; LOW DENSITY LIPOPROTEIN; LYCOPENE; TRIACYLGLYCEROL; XANTHOPHYLL; ZEAXANTHIN;

ADULT; ARTICLE; CONTROLLED STUDY; CORRELATION FUNCTION; FEMALE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; LIPID ANALYSIS; MALE; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL;

ADULT; ANTIOXIDANTS; CAROTENOIDS; FEMALE; HUMANS; LIPOPROTEINS, LDL; MALE; MIDDLE AGED; STATISTICS; VITAMIN E;

EID: 0029793044     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Street, D. A., G. W. Comstock, R. M. Salkeld, W. Schüep, and M. J. Klag. 1994. Serum antioxidants and myocardial infarction. Circulation. 90: 1154-1161.
2. Sowell, A. L., D. L. Huff, P. R. Yeager, S. P. Caudill, and E. W. Gunter. 1994. Retinol, α-tocopherol, lutein/zeaxanthin, β-cryptoxanthin, lycopene, α-carotene, trans-β-carotene, and four retinyl esters in serum determined simultaneously by reversed-phase HPLC with multiwavelength detection. Clin. Chem. 40: 411-416.
3. Olmedilla, B., F. Granado, I. Blanco, and E. Rojas-Hidalgo. 1994. Seasonal and sex-related variations in six serum carotenoids, retinol, and α-tocopherol. Am. J. Clin. Nutr. 60: 106-110.
4. Heseker, H., R. Schneider, K. J. Moch, M. Kohlmeier, and W. Kübler. 1994. Vitaminversorgung Erwachsener in der Bundesrepublik Deutschland. In VERA-Schriftenreihe Band IV. Wissenschaftlicher Fachverlag Dr. Fleck, Niederkleen, Germany. IV: 25-34, 43-47.
5. Esterbauer, H., G. Waeg, and H. Puhl. 1993. Lipid peroxidation and its role in atherosclerosis. Br. Med. Bull. 49: 566-576.
6. Frei, B., and M. Gaziano. 1993. Content of antioxidants, preformed lipid hydroperoxides, and cholesterol as predictors of the susceptibility of human LDL to metal ion-dependent and -independent oxidation. J. Lipid Res. 34: 2135-2145.
7. Jialal, I., and S. M. Grundy. 1992. Effect of dietary supplementation with alpha-tocopherol on the oxidative modification of low density lipoprotein. J. Lipid Res. 33: 899-906.
8. Dieber-Rotheneder, M., H. Puhl, G. Waeg, G. Striegl, and H. Esterbauer. 1991. Effect of oral supplementation with D-alpha-tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation. J. Lipid Res. 32: 1325-1332.
9. Princen, H. M., W. van Duyvenvoorde, R. Buytenhek, A. van der Laarse, G. van Poppel, J. A. Gevers-Leuven, and V. W. van Hinsbergh. 1995. Supplementation with low doses of vitamin E protects LDL from lipid peroxidation in men and women. Arterioscler. Thromb. Vasc. Biol. 15: 325-333.
10. Princen, H. M., G. van Poppel, C. Vogelezang, R. Buytenhek, and F. J. Kok. 1992. Supplementation with vitamin E but not β-carotene in vivo protects low density lipoprotein from lipid peroxidation in vitro. Arterioscler. Thromb. 12: 554-562.
11. Reaven, P. D., E. Ferguson, M. Navab, and F. L. Powell. 1994. Susceptibility of human LDL to oxidative modification - effects of variations in beta-carotene concentration and oxygen tension. Arterioscler. Thromb. 14: 1162-1169.
12. Traber, M. G., J. C. Lane, N. R. Lagmay, and H. J. Kayden. 1992. Studies on the transfer of tocopherol between lipoproteins. Lipids. 27: 657-663.
13. Kayden, H. J., and M. G. Traber. 1993. Absorption, lipoprotein transport, and regulation of plasma concentrations of vitamin E in humans. J. Lipid Res. 34: 343-358.
14. Kostner, G. M., K. Oettel, M. Jauhianer, C. Ehnholm, H. Esterbauer, and H. Dieplinger. 1995. Human plasma phospholipid transfer protein accelerates exchange/transfer of α-tocopherol between lipoproteins and cells. Biochem. J. 305: 659-667.
15. Massey, J. B. 1984. Kinetics of transfer of alpha-tocopherol between model and native plasma lipoproteins. Biochim. Biophys. Acta. 793: 387-392.
16. Steinberg, D., S. Parthasarathy, T. E. Carew, J. C. Khoo, and J. S. Witztum. 1989. Beyond cholesterol. Modifications of low density lipoprotein that increase its atherogenicity. N. Engl. J. Med. 320: 915-924.
17. Steinberg, D. 1995. Clinical trials of antioxidants in atherosclerosis: are we doing the right thing? Lancet. 346: 36-38.
18. Esterbauer, H., and P. Ramos. 1995. Chemistry and pathophysiology of oxidation of LDL. Rev. Physiol. Biochem. Pharmacol. 127: 31-64.
19. Gey, K. F. 1993. Vitamin E and other essential antioxidants regarding coronary heart disease: risk assessment studies. In Vitamin E in Health and Disease. L. Packer and J. Fuchs, editors. Marcel Dekker, New York. 589-633.
20. Gaziano, H. M., J. E. Mandon, and C. H. Hennekens. 1994. Natural antioxidants and cardiovascular disease: observational epidemiologic studies and randomized trials. In Natural Antioxidants in Human Health and Disease. B. Frei, editor. Academic Press, San Diego. 387-409.
21. Rimm, E. B., M. J. Stampfer, A. Asherio, E. Giovannucci, G. A. Colditz, and W. Willett. 1993. Vitamin E consumption and the risk of coronary heart disease in men. N. Engl. J. Med. 328: 1450-1456.
22. Stampfer, M. J., C. H. Hennekens, J. E. Manson, G. A. Colditz, B. Rosner, and W. Willett. 1993. Vitamin E consumption and the risk of coronary heart disease in women. N. Engl. J. Med. 328: 1444-1449.
23. Winklhofer-Roob, B. M., O. Ziouzenkova, H. Puhl, H. Ellemunter, P. Greiner, G. Müller, M. A. van't Hof, H. Esterbauer, and D. H. Shmerling. 1995. Impaired resistance to oxidation of low density lipoprotein in cystic fibrosis: improvement during vitamin E supplementation. Free Radic. Biol. Med. 19: 725-733.
24. Winklhofer-Roob, B. M., H. Puhl, G. Khoschsorur, M. A. van't Hof, H. Esterbauer, and D. H. Shmerling. 1994. Enhanced resistance to oxidation of low density lipoproteins and decreased lipid peroxide formation during β-carotene supplementation in cystic fibrosis. Free Radic. Biol. Med. 18: 849-859.
25. Ramos, P., S. P. Gieseg, B. Schuster, and H. Esterbauer. 1995. Effect of temperature and phase transition on oxidation resistance of low density lipoprotein. J. Lipid Res. 36: 2113-2128.
26. Esterbauer, H., J. Gebicki, H. Puhl, and G. Juergens. 1992. The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Radic. Biol. Med. 13: 341-390.
27. Thurnham, D. I., J. A. Davies, B. J. Crump, R. D. Situnayake, and M. Davis. 1986. The use of different lipids to express serum tocopherol: lipid ratios for the measurement of vitamin E status. Ann. Clin. Biochem. 23: 514-520.
28. Gey, K. F., and P. Puska. 1989. Plasma vitamins E and A inversely correlated to mortality from ischemic heart disease in cross-cultural epidemiology. Ann. NY Acad. Sci. 570: 268-283.
29. Gey, K. F. 1995. Prevention of early stages of cardiovascular disease and cancer may require concurrent optimization of all major antioxidants and other nutrients: an update and reevaluation of observational data and intervention trials. In Free Radicals, Lipoprotein Oxidation and Atherosclerosis. G. Bellomo, E. Maggi and C. Rice-Evans, editors. Richelieu Press, London. 53-99.
30. Friedewald, W. T., R. I. Levy, and D. S. Fredrickson. 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18: 499-502.
31. Behrens, W. A., J. N. Thompson, and R. Madère. 1982. Distribution of α-tocopherol in human plasma lipoproteins. Am. J. Clin. Nutr. 35: 691-696.
32. Dejager, S., E. Bruckert, and M. J. Chapman. 1993. Dense low density lipoprotein subspecies with diminished oxidative resistance predominate in combined hyperlipidemia. J. Lipid Res. 34: 295-308.
33. Sies, H., W. Stahl, and A. R. Sundquist. 1992. Antioxidant functions of vitamins. Ann. NY Acad. Sci. 669: 7-20.
34. Bowry, V. W., and R. Stocker. 1993. Tocopherol-mediated peroxidation - the prooxidant effect of vitamin E on the radical initiated oxidation of human low-density lipoprotein. J. Am. Chem. Soc. 115: 6029-6044.
35. Traber, M. G., W. Cohn, and D. P. R. Muller. 1993. Absorption, transport and delivery to tissues. In Vitamin E in Health and Disease. L. Packer, and J. Fuchs, editors. Marcel Dekker, New York. 35-57.
36. Ogihara, T., M. Miki, M. Kitagawa, and M. Mino. 1988. Distribution of tocopherol among human plasma lipoproteins. Clin. Chin. Acta. 174: 299-306.
37. Romanchik, J. E., D. W. Morel, and E. H. Harrison. 1995. Distribution of carotenoids and alpha-tocopherol among lipoproteins does not change when human plasma is incubated in vitro. J. Nutr. 125: 2610-2617.
38. Krinsky, N. I., D. G. Cornwell, and J. L. Oncley. 1958. The transport of vitamin A and carotenoids in human plasma. Arch. Biochem. Biophys. 73: 233-246.
39. Clevidence, B. A., and J. G. Bieri. 1993. Association of carotenoids with human plasma lipoproteins. Methods Enzymol. 214: 33-46.
40. Bjornson, L. K., H. J. Kayden, E. Miller, and A. N. Moshell. 1976. The transport of α-tocopherol and β-carotene in human blood. J. Lipid Res. 17: 343-352.
41. Traber, M. G., S. R. Diamond, J. C. Lane, R. I. Brody, and H. J. Kayden. 1994. β-Carotene transport in human lipoproteins. Comparisons with α-tocopherol. Lipids. 29: 665-669.
42. Esterbauer, H., H. Puhl, G. Waeg, A. Krebs, and M. Dieber-Rotheneder. 1993. The role of vitamin E in lipoprotein oxidation. In Vitamin E in Health and Disease. L. Packer and J. Fuchs, editors. Marcel Dekker, New York. 649-671.
43. Jandak, J., M. Steiner, and P. D. Richardson. 1988. Reduction of platelet adhesiveness by vitamin E supplementation in humans. Thromb. Res. 49: 393-404.
44. Boscoboinik, D., N. K. Ozer, U. Moser, and A. Azzi. 1995. Tocopherols and 6-hydroxy-chroman-2-carbonitrile derivatives inhibit vascular smooth muscle cell proliferation by a nonantioxidant mechanism. Arch. Biochem. Biophys. 318: 241-246.
45. Faruqi, R., C. de la Motte, and P. E. Di Corleto. 1994. Alpha-tocopherol inhibits agonist-induced monocytic cell adhesion to cultured human endothelial cells. J. Clin. Invest. 94: 592-600.