Large variations in human foam cell formation in individuals: A fully autologous in vitro assay based on the quantitative analysis of cellular neutral lipids

Atherosclerosis

Volumn 148, Issue 2, 2000, Pages 243-253

  Asmis, Reto ^a   Jelk, Jennifer ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Aggregated low density lipoprotein; Atherosclerosis; Cholesterol; Foam cells; Macrophages

Indexed keywords

CHOLESTEROL; CHOLESTEROL ESTER; COPPER ION; LIPID; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; OXIDIZED LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL;

ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR RISK; CELL CULTURE; CELL DIFFERENTIATION; CELL LEVEL; CONTROLLED STUDY; DENSITOMETRY; FOAM CELL; HUMAN; HUMAN CELL; LASER; MACROPHAGE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; SERUM; TECHNIQUE; THIN LAYER CHROMATOGRAPHY; VARIANCE; VOLUNTEER;

CELL DIFFERENTIATION; CELL DIVISION; CELLS, CULTURED; CHOLESTEROL ESTERS; CYTOLOGICAL TECHNIQUES; FOAM CELLS; HUMANS; LIPID METABOLISM; LIPIDS; LIPOPROTEINS, LDL; MACROPHAGES; MALE; VARIATION (GENETICS);

EID: 0033956348     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(99)00268-3     Document Type: Article

References (46)

1. Vasile E., Simionescu M., Simionescu N. Visualization of the binding, endocytosis and transcytosis of low density lipoproteins in the arterial endothelium in situ. J. Cell Biol. 96:1983;1677-1689.
2. Schwenke D.C., Carew T.E. Initiation of atherosclerotic lesions in cholesterol-fed rabbits. II. Selective retention of LDL versus selective increases in LDL permeability in susceptible sites of arteries. Arteriosclerosis. 9:1989;908-918.
3. Nievelstein P.F., Fogelman A.M., Mottino G., Frank J.S. Lipid accumulation in rabbit aortic intima 2 h after bolus infusion of low density lipoprotein. A deep-etch and immunolocalization study of ultrarapidly frozen tissue. Arterioscler. Thromb. 11:1991;1795-1805.
4. Vijayagopal P., Srinivasan S.R., Radhakrishnamurthy B., Berenson G.S. Interaction of serum lipoproteins and a proteoglycan from bovine aorta. J. Biol. Chem. 256:1981;8234-8241.
5. Hurt Camejo E., Camejo G., Rosengren B., Lopez F., Ahlstrom C., Fager G. et al. Effect of arterial proteoglycans and glycosaminoglycans on low density lipoprotein oxidation and its uptake by human macrophages and arterial smooth muscle cells. Arterioscler. Thromb. 12:1992;569-583.
6. Steinbrecher U.P., Parthasarathy S., Leake D.S., Witztum J.L., Steinberg D. Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proc. Natl. Acad. Sci. USA. 81:1984;3883-3887.
7. Libby P., Geng Y.J., Aikawa M., Schoenbeck U., Mach F., Clinton S.K. et al. Macrophages and atherosclerotic plaque stability. Curr. Opin. Lipidol. 7:1996;330-335.
8. Libby P., Clinton S.K. The role of macrophages in atherogenesis. Curr. Opin. Lipidol. 4:1993;355-363.
9. Goldstein J.L., Ho Y.K., Basu S.K., Brown M.S. Binding site on macrophages that mediate uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc. Natl. Acad. Sci. USA. 76:1979;333-337.
10. Rohrer L., Freeman M., Kodama T., Penman M., Krieger M. Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II. Nature. 343:1990;570-572.
11. Kodama T., Freeman M., Rohrer L., Zabrecky J., Matsudaira P., Krieger M. Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils. Nature. 343:1990;531-535.
12. Basu S.K., Goldstein J.L., Anderson G.W., Brown M.S. Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts. Proc. Natl. Acad. Sci. USA. 73:1976;3178-3182.
13. Haberland M.E., Fogelman A.M., Edwards P.A. Specificity of receptor-mediated recognition of malondialdehyde- modified low density lipoproteins. Proc. Natl. Acad. Sci. USA. 79:1982;1712-1716.
14. Lopes Virella M.F., Klein R.L., Lyons T.J., Stevenson H.C., Witztum J.L. Glycosylation of low-density lipoprotein enhances cholesteryl ester synthesis in human monocyte-derived macrophages. Diabetes. 37:1988;550-557.
15. Colaco C.A., Roser B.J. Atherosclerosis and glycation. Bioassays. 16:1994;145-147.
16. Henriksen T., Mahoney E.M., Steinberg D. Interactions of plasma lipoproteins with endothelial cells. Ann. New York Acad. Sci. 401:1982;102-116.
17. Henriksen T., Mahoney E.M., Steinberg D. Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins. Proc. Natl. Acad. Sci. USA. 78:1981;6499-6503.
18. Henriksen T., Mahoney E.M., Steinberg D. Enhanced macrophage degradation of biologically modified low density lipoprotein. Arteriosclerosis. 3:1983;149-159.
19. Suits A.G., Chait A., Aviram M., Heinecke J.W. Phagocytosis of aggregated lipoprotein by macrophages: low density lipoprotein receptor-dependent foam-cell formation. Proc. Natl. Acad. Sci. USA. 86:1989;2713-2717.
20. Khoo J.C., Miller E., McLoughlin P., Steinberg D. Enhanced macrophage uptake of low density lipoprotein after self- aggregation. Arteriosclerosis. 8:1988;348-358.
21. Hurt E., Bondjers G., Camejo G. Interaction of LDL with human arterial proteoglycans stimulates its uptake by human monocyte-derived macrophages. J. Lipid Res. 31:1990;443-454.
22. Vijayagopal P., Srinivasan S.R., Jones K.M., Radhakrishnamurthy B., Berenson G.S. Complexes of low-density lipoproteins and arterial proteoglycan aggregates promote cholesteryl ester accumulation in mouse macrophages. Biochim. Biophys. Acta. 837:1985;251-261.
23. Salisbury B.G., Falcone D.J., Minick C.R. Insoluble low-density lipoprotein-proteoglycan complexes enhance cholesteryl ester accumulation in macrophages. Am. J. Pathol. 120:1985;6-11.
24. Heinecke J.W., Suits A.G., Aviram M., Chait A. Phagocytosis of lipase-aggregated low density lipoprotein promotes macrophage foam cell formation. Sequential morphological and biochemical events. Arterioscler. Thromb. 11:1991;1643-1651.
25. Tertov V.V., Sobenin I.A., Gabbasov Z.A., Popov E.G., Orekhov A.N. Lipoprotein aggregation as an essential condition of intracellular lipid accumulation caused by modified low density lipoproteins. Biochem. Biophys. Res. Commun. 163:1989;489-494.
26. Tertov V.V., Orekhov A.N., Sobenin I.A., Gabbasov Z.A., Popov E.G., Yaroslavov A.A. et al. Three types of naturally occurring modified lipoproteins induce intracellular lipid accumulation due to lipoprotein aggregation. Circ. Res. 71:1992;218-228.
27. Stary H.C., Chandler A.B., Glagov S., Guyton J.R., Insull W.J.r, Rosenfeld M.E. et al. A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Atherosclerosis, American Heart Association. Circulation. 89:1994;2462-2478.
28. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 362:1993;801-809.
29. Wintergerst E.S., Jelk J., Asmis R. Differential expression of CD14, CD36 and the LDL receptor on human monocyte-derived macrophages. A novel cell culture system to study macrophage differentiation and heterogeneity. Histochem. Cell. Biol. 110:1998;231-241.
30. Asmis R., Llorente V.C., Gey K.F. Prevention of cholesteryl ester accumulation in P388D1 macrophage-like cells by increased cellular vitamin E depends on species of extracellular cholesterol. Conventional heterologous non-human cell cultures are poor models of human atherosclerotic foam cell formation. Eur. J. Biochem. 233:1995;171-178.
31. Esterbauer H., Striegl G., Puhl H., Rotheneder M. Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radic. Res. Commun. 6:1989;67-75.
32. Asmis R., Bühler E., Jelk J., Gey K.F. Concurrent quantification of cellular cholesterol, cholesteryl esters and triglycerides in small biological samples. J. Chromatogr. 691:1997;59-66.
33. Bligh E.G., Dyer W.J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37:1959;911-917.
34. Brunk C.F., Jones K.C., James T.W. Assay for nanogram quantities of DNA in cellular homogenates. Anal. Biochem. 92:1979;497-500.
35. Schwartz C.J., Valente A.J., Sprague E.A., Kelley J.L., Cayatte A.J., Mowery J. Atherosclerosis: potential targets for stabilization and regression. Circulation. 86:1992;117-123.
36. Koren E., Koscec M., McConathy W.J., Fugate R.D. Possible role of macrophages in regression of atherosclerosis. Prog. Lipid Res. 30:1991;237-243.
37. Aviram M., Maor I., Keidar S., Hayek T., Oiknine J., Bar-El Y. et al. Lesioned low density lipoprotein in atherosclerotic apolipoprotein E-deficient mice and humans is oxidized and aggregated. Biochem. Biophys. Res. Commun. 216:1995;501-513.
38. Kawabe Y., Cynshi O., Takashima Y., Suzuki T., Ohba Y., Kodama T. Oxidation-induced aggregation of rabbit low-density lipoprotein by azo initiator. Arch. Biochem. Biophys. 310:1994;489-496.
39. Maeba R., Shimasaki H., Ueta N. Conformational changes in oxidized LDL recognized by mouse peritoneal macrophages. Biochim. Biophys. Acta. 1215:1994;79-86.
40. Tertov V.V., Kaplun V.V., Orekhov A.N. In vivo oxidized low density lipoprotein: degree of lipoprotein oxidation does not correlate with its atherogenic properties. Mol. Cell. Biochem. 183:1998;141-146.
41. Asmis R., Wintergerst E.S. Dehydroascorbic acid prevents apoptosis induced by oxidized low density lipoprotein in human monocyte-derived macrophages. Eur. J. Biochem. 255:1998;147-155.
42. Chisolm G.M., Guoping M., Irwin K.C., Martin L.L., Gunderson K.G., Linberg L.F. et al. 7β-Hydroperoxycholest-5-en-3β-ol, a component of human atherosclerotic lesions, is the primary cytotoxin of oxidized human low density lipoprotein. Proc. Natl. Acad. Sci. USA. 91:1994;11452-11456.
43. Suarna C., Dean R.T., May J., Stocker R. Human atherosclerotic plaque contains both oxidized lipids and relatively large amounts of α-tocopherol and ascorbate. Arterioscler. Thromb. Vasc. Biol. 15:1995;1616-1624.
44. Carpenter K.L.H., Wilkins G.M., Fussell B., Ballantine J.A., Taylor S.E., Mitchinson M.J. et al. Production of oxidized lipids during modification of low-density lipoprotein by macrophages or copper. Biochem. J. 304:1994;625-633.
45. Marchant C.E., Law N.S., van der Veen C., Hardwick S.J., Carpenter K.L., Mitchinson M.J. Oxidized low-density lipoprotein is cytotoxic to human monocyte- macrophages: protection with lipophilic antioxidants. FEBS Lett. 358:1995;175-178.
46. Pentikainen M.O., Lehtonen E.M., Kovanen P.T. Aggregation and fusion of modified low density lipoprotein. J. Lipid Res. 37:1996;2638-2649.