Review article: Helicobacter pylori vaccines - The current status

Alimentary Pharmacology and Therapeutics

Volumn 14, Issue 9, 2000, Pages 1107-1118

  Sutton, ^a   Lee, ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; BACTERIAL VACCINE; BACTERIUM ANTIBODY; CD4 ANTIGEN; HELICOBACTER PYLORI VACCINE; IMMUNOLOGICAL ADJUVANT; UNCLASSIFIED DRUG;

BACTERIAL COLONIZATION; CELLULAR IMMUNITY; DRUG ADMINISTRATION ROUTE; DRUG EFFICACY; DRUG INDICATION; DRUG MECHANISM; GASTRITIS; HELICOBACTER PYLORI; HELPER CELL; HUMORAL IMMUNITY; IMMUNIZATION; NONHUMAN; PEPTIC ULCER; PRIORITY JOURNAL; REVIEW; STOMACH ADENOCARCINOMA; VACCINE PRODUCTION;

ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL VACCINES; GASTRITIS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; RESEARCH;

EID: 0033802831     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.2000.00825.x     Document Type: Review

References (63)

1. Immunisation against Helicobacter infection in a mouse/Helicobacter felis model
2. A small animal model of human Helicobacter pylori active chronic gastritis
3. Development of a mouse model of Helicobacter pylori infection that mimics human disease
4. A standardized mouse model of Helicobacter pylori infection - Introducing the Sydney strain
5. Frontiers in Helicobacter pylori research - Pathogenesis, host response, vaccine development and new therapeutic approaches
6. Oral immunization with urease and Escherichia coli heat-labile enterotoxin is safe and immunogenic in Helicobacter pylori-infected adults
7. Immunization with recombinant Helicobacter pylori urease decreases colonization levels following experimental infection of Rhesus monkeys
8. Immunization against natural Helicobacter pylori infection in nonhuman primates
9. Immunization of rhesus monkeys with a mucosal prime, parenteral boost strategy protects against infection with Helicobacter pylori
10. Immunization with recombinant Helicobacter pylori urease in specific-pathogen-free Rhesus monkeys (Macaca mulatta)
11. Immunogenicity and safety of recombinant Helicobacter pylori urease in a nonhuman primate
12. Vaccination of gnotobiotic piglets against Helicobacter pylori
13. Therapeutic immunization against Helicobacter mustelae in naturally infected ferrets
14. Protection against Helicobacter pylori infection in mice by intragastric vaccination with H. pylori antigens is achieved using a non-toxic mutant of IX. coli heat-labile enterotoxin (LT) as adjuvant
15. Successful immunization against gastric infection with Helicobacter species: Use of a cholera toxin B-subunit-whole-cell vaccine
16. Recombinant cholera toxin B subunit is not an effective mucosal adjuvant for oral immunization of mice against Helicobacter felis
17. Parenteral adjuvant activities of Escherichia coli heat-labile toxin and its B subunit for immunization of mice against Helicobacter pylori infection
18. Promotion of ulcerative duodenitis in young ferrets by oral immunization with Helicobacter mustelae and muramyl dipeptide
19. Further development of the Helicobacter pylori mouse vaccination model
20. Systemic immunization with urease protects mice against Helicobacter pylori infection
21. Interrupting the transmission of wild polioviruses with vaccines: Immunological considerations
22. Post-market experience with live oral Ty21a vaccine
23. Live oral vaccines against cholera: An update
24. Immunogenicity of a Salmonella typhimurium aroA aroD vaccine expressing a nontoxic domain of Clostridium difficile toxin A
25. Mice are protected from Helicobacter pylori infection by nasal immunization with attenuated Salmonella typhimurium phoP (c) expressing urease A and B subunits
26. Protection of mice against gastric colonization by Helicobacter pylori by single oral dose immunization with attenuated Salmonella typhimurium producing urease subunits A and B
27. Safety and immunogenicity of phoP/phoQ-deleted Salmonella typhi expressing Helicobacter pylori urease in adult volunteers
28. Pilot study of phoP/phoQ-deleted Salmonella enterica serovar Typhimurium expressing Helicobacter pylori urease in adult volunteers
29. Replication-defective adenovirus infection reduces Helicobacter felis colonization in the mouse in a gamma interferon- and interleukin-12-dependent manner
30. Poliovirus replicons encoding the B subunit of Helicobacter pylori urease elicit a Th1 associated immune response
31. Induction of mucosal and systemic immune response by oral immunization with H. pylori lysates encapsulated in poly (D,L-lactide-co-glycolide) microparticles
32. Generation of a monoclonal antibody to a defined portion of the Helicobacter pylori vacuolating cytotoxin by DNA immunization
33. DNA immunization decreases the level of infection in the felis-mouse model, irrespective of the titre of specific antibodies. IXth International Workshop on gastroduodenal pathology and Helicobacter pylori. Copenhagen, Denmark
34. Injection of plasmid DNA into the gastric mucosa induces mucosal and systemic immunity
35. Rectal and intranasal immunizations with recombinant urease induce distinct local and serum immune responses in mice and protect against Helicobacter pylori infection
36. Novel intranasal immunization techniques for antibody induction and protection of mice against gastric Helicobacter felis infection
37. Immunization of mice with urease vaccine affords protection against Helicobacter pylori infection in the absence of antibodies and is mediated by MHC class II-restricted responses
38. Protection against Helicobacter pylori infection by intestinal immunisation with a 50/52-kDa subunit protein
39. Comparison between targeted and untargeted systemic immunizations with adjuvanted urease to cure Helicobacter pylori infection in mice
40. Systemic vaccination inducing either Th1 or Th2 immunity protects mice from challenge with H. pylori
41. Gastritis in urease-immunized mice after Helicobacter felis challenge may be due to residual bacteria
42. Local secretory immunoglobulin A and postimmunization gastritis correlate with protection against Helicobacter pylori infection after oral vaccination of mice
43. Post-immunization gastritis in Helicobacter immunized/challenged mice
44. Oral immunization against Helicobacter pylori
45. Protection of germ-free mice from infection by Helicobacter felis after active oral or passive IgA immunization
46. Oral immunization with recombinant Helicobacter pylori urease induces secretory IgA antibodies and protects mice from challenge with Helicobacter felis
47. Effect of oral immunization with recombinant urease on murine Helicobacter felis gastritis
48. Local immune response to gastric Campylobacter in non-ulcer disease
49. Antibody-independent protective mucosal immunity to gastric Helicobacter infection in mice
50. Local immunoglobulin G antibodies in the stomach may contribute to immunity against Helicobacter infection in mice
51. Therapeutic immunization against Helicobacter pylori infection in the absence of antibodies
52. Helicobacter-specific cell-mediated immune responses display a predominant TH1 phenotype and promote a delayed-type hypersensitivity response in the stomachs of mice
53. Interferon-gamma and tumor necrosis factor production in patients with Helicobacter pylori infection
54. Interferon gamma and interleukin 4 secreting cells in the gastric antrum in Helicobacter pylori positive and negative gastritis
55. T helper 1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease
56. Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype
57. Role of gamma interferon in Helicobacter pylori-induced gastric inflammatory responses in a mouse model
58. Helicobacter pylori infection in immunized mice lacking major histocompatibility complex class I and class II functions
59. Murine CD4 T-cell response to Helicobacter infection - TH1 cells enhance gastritis and TH2 cells reduce bacterial load
60. Immunization of BALB/c mice with Helicobacter urease B induces a T helper 2 response absent in Helicobacter infection
61. Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4
62. Antibiotic resistance in Helicobacter pylori infection
63. Alternative projections of mortality and disability by cause 1990-2020 - Global burden of disease study