Rectal and intranasal immunizations with recombinant urease induce distinct local and serum immune responses in mice and protect against Helicobacter pylori infection

Infection and Immunity

Volumn 66, Issue 6, 1998, Pages 2879-2886

  Kleanthous, Harry ^a   Myers, Gwendolyn A ^a   Georgakopoulos, Kathleen M ^a   Tibbitts, Timothy J ^a   Ingrassia, Jennifer W ^a   Gray, Heather L ^a   Ding, Ru ^a   Zhang, Zhen Zi ^a   Lei, Wende ^a   Nichols, Richard ^a   Lee, Cynthia K ^a   Ermak, Thomas H ^a   Monath, Thomas P ^a  

^a Acambis   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

UREASE;

ACTIVE IMMUNIZATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; ESCHERICHIA COLI; GRAM NEGATIVE INFECTION; HELICOBACTER PYLORI; IMMUNOGENICITY; IMMUNOHISTOCHEMISTRY; INFECTION PREVENTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 0031812740     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.6.2879-2886.1998     Document Type: Article

References (27)

1. Atherton, J. C., K. T. Tham, R. M. Peek, Jr., T. L. Cover, and M. J. Blaser. 1996. Density of Helicobacter pylori infection as assessed by quantitative culture and histology. J. Infect. Dis. 174:552-556.
2. Chen, M., A. Lee, S. Hazell, P. Hu, and Y. Li. 1993. Immunization against infection with Helicobacter species: first step in the prophylaxis of gastric cancer? Zentbl. Bakteriol. 280:155-165.
3. Czinn, S. J., A. Cai, and J. G. Nedrud. 1993. Protection of germ-free mice from infection by Helicobacter felis after oral or passive IgA immunization. Vaccine 11:637-642.
4. Ermak, T. H., R. Ding, B. Ekstein, G. Myers, C. K. Lee, J. Pappo, H. Kleanthous, and T. P. Monath. 1997. Gastritis in urease-immunized mice after Helicobacter felis challenge may be due to residual bacteria. Gastroenterology 113:1118-1128.
5. Ferrero, R. L., J. M. Thilberge, I. Kansau, N. Wuchser, M. Huerra, and A. Labigne. 1995. The GroES homologue of Helicobacter pylori confers protective immunity against mucosal infection in mice. Proc. Natl. Acad. Sci. USA 92:6499-6503.
6. Ferrero, R. L., J. M. Thilberge, and A. Labigne. 1996. Local immunoglobulin G antibodies, and not IgA, contribute to protective immunity against gastric H. felis infection in mice. Gut 39(Suppl. 2):A44.
7. Forman, D., and P. Webb. 1993. Geographic distribution and association with gastric cancer, p. 11-20. In T. C. Northfield et al. (ed.), Helicobacter pylori infection. Kluwer Academic Publishers, Dordrecht, The Netherlands.
8. Fox, J. G., M. Blanco, J. C. Murphy, N. S. Taylor, A. Lee, Z. Kabok, and J. Pappo. 1993. Local and systemic immune responses in murine Helicobacter felis active chronic gastritis. Infect. Immun. 61:2309-2315.
9. Haneberg, B., D. Kendall, H. M. Amerongen, F. M. Apter, J.-P. Kraehenbuhl, and M. R. Neutra. 1994. Induction of specific immunoglobulin A in the small intestine, colon-rectum, and vagina measured by a new method for collection of secretions from local mucosal surfaces. Infect. Immun. 62:15-23.
10. Kleanthous, H., T. Tibbitts, T. J. Bakios, K. Georgokopoulos, G. Myers, T. H. Ermak, J. G. Fox, and T. P. Monath. 1995. In-vivo selection of a highly adapted H. pylori isolate and the development of an H. pylori mouse model for studying vaccine efficacy. Gut 37:A94.
11. Kolesnikow, T., F. J. Radcliff, S. L. Hazell, C. Doidge, and A. Lee. 1996. Helicobacter pylori catalase: a novel antigen for vaccination. Gut 39(Suppl. 2):A46.
12. Lee, A., J. O'Rourke, M. Corazon de Ungria, B. Robertson, G. Daskalopoulos, and M. F. Dixon. 1997. A standardized mouse model of Helicobacter pylori infection: introducing the Sydney strain. Gastroenterology 112:1386-1397.
13. Lee, C. K., R. Weltzin, W. D. Thomas, Jr., H. Kleanthous, T. H. Ermak, S. Gopalan, J. E. Hill, S. K. Ackerman, and T. P. Monath. 1995. Oral immunization with recombinant Helicobacter pylori urease induces secretory IgA antibodies and protects mice from challenge with Helicobacter felis. J. Infect. Dis. 172:161-172.
14. Malfertheiner, P. 1993. Compliance, adverse events and antibiotic resistance in Helicobacter pylori treatment. Scand. J. Gastroenterol. 28(Suppl. 196):34-37.
15. Marchetti, M., B. Arico, D. Burroni, N. Figura, R. Rappuoli, and P. Ghiara. 1995. Development of a mouse model of Helicobacter pylori infection that mimics human disease. Science 267:1655-1658.
16. Marshall, J. 1994. Epidemiology of H. pylori in Western countries, p. 75-84. In R. H. Hunt and G. N. J. Tytgat (ed.), Helicobacter pylori. Basic mechanisms top clinical cure. Kluwer Academic Publishers, Dordrecht, The Netherlands.
17. Michetti, P., I. Corthesy-Theulaz, C. Davin, R. Haas, A.-C. Vaney, M. Heitz, J. Bille, J.-P. Kraehenbuhl, E. Saraga, and A. L. Blum. 1994. Immunization of BALB/c mice against Helicobacter felis infection with Helicobacter pylori urease. Gastroenterology 107:1002-1011.
18. Mitchell, H. M. 1993. The epidemiology of Helicobacter pylori infection and its relation to gastric cancer, p. 95-114. In C. S. Goodwin and B. W. Worsley (ed.), Helicobacter pylori: biology and clinical practice. CRC Press, Boca Raton, Fia.
19. Myers, G., T. H. Ermak, K. Georgokopoulos, T. Tibbits, J. Bakios, H. Gray, J. Pappo, H. Kleanthous, C. K, Lee, and T. P. Monath. 1996. Oral immunization with recombinant urease confers long-lasting immunity. Gut 39(Suppl. 2):A44.
20. Oderda, G., D. Vaira, and C. Ainley. 1992. Eighteen month follow-up of H. pylori positive children treated with amoxycillin and tinidazole. Dig. Dis. Sci. 36:572-576.
21. Pappo, J., W. D. Thomas, Jr., Z. Kabok, N. S. Taylor, J. C. Murphy, and J. G. Fox. 1995. Effect of oral immunization with recombinant urease on murine Helicobacter felis gastritis. Infect. Immun. 63:1246-1252.
22. Parsonnet, J., I. M. Samloff, L. M. Nelson, et al. 1993. Helicobacter pylori, pepsinogen and risk for gastric adenocarcinoma. Cancer Epidemiol. Biomark. Prev. 2:1-7.
23. Solnick, L. V., and L. S. Tompkins. 1993. Helicobacter pylori and gastroduodenal disease: pathogenesis and host-parasite interaction. Infect. Agents Dis. 1:294-309.
24. Thomas, J. E., S. Austin, A. Dale, et al. 1993. Protection by human milk IgA against Helicobacter pylori infection in infancy. Lancet 342:121.
25. Weltzin, R., H. Kleanthous, F. Guirakhoo, T. P. Monath, and C. K. Lee. 1997. Novel intranasal immunization techniques for antibody induction and protection of mice against gastric Helicobacter felis infection. Vaccine 15: 370-376.
26. Witherspoon, A. C., C. Doglioni, T. C. Diss, et al. 1993. Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet 342:575-577.
27. World Health Organization. 1996. Infectious diseases and cancer, p. 59-62. In The state of world health. World Health Organization, Geneva, Switzerland.