Immunization with recombinant Helicobacter pylori urease decreases colonization levels following experimental infection of rhesus monkeys

Vaccine

Volumn 17, Issue 11-12, 1999, Pages 1493-1505

  Lee, Cynthia K ^a   Soike, Kenneth ^b   Hill, Joseph ^c   Georgakopoulos, Kathleen ^a   Tibbitts, Timothy ^a   Ingrassia, Jennifer ^a   Gray, Heather ^a   Boden, James ^a   Kleanthous, Harold ^a   Giannasca, Paul ^a   Ermak, Thomas ^a   Weltzin, Richard ^a   Blanchard, James ^b   Monath, Thomas P ^a  

^a Acambis   (United States)

^b TULANE NATIONAL PRIMATE RESEARCH CENTER   (United States)

^c CLEMSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BISMUTH SALICYLATE; CLARITHROMYCIN; ESCHERICHIA COLI ENTEROTOXIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; METRONIDAZOLE; OMEPRAZOLE; RECOMBINANT VACCINE; UREASE;

ANIMAL EXPERIMENT; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GROWTH; BACTERIUM CULTURE; CONTROLLED STUDY; DRUG EFFICACY; GASTRITIS; GASTROSCOPY; GRAM NEGATIVE INFECTION; HELICOBACTER PYLORI; HISTOPATHOLOGY; IMMUNOGENICITY; INTRAGASTRIC DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; STOMACH BIOPSY; VACCINATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIBODIES, BACTERIAL; BACTERIAL TOXINS; BACTERIAL VACCINES; BISMUTH; CLARITHROMYCIN; DRUG THERAPY, COMBINATION; ENTEROTOXINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI PROTEINS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; MACACA MULATTA; METRONIDAZOLE; OMEPRAZOLE; ORGANOMETALLIC COMPOUNDS; RECOMBINANT PROTEINS; SALICYLATES; SALIVA; UREASE;

EID: 0033577342     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(98)00365-X     Document Type: Article

References (33)

1. NIH Consensus Development Panel on Helicobacter pylori in Peptic Ulcer Disease NIH consensus conference: Helicobacter pylori in peptic ulcer disease. Journal American Medical Association. 272:1994;65-69.
2. The EUROGAST Study Group Epidemiology of, and risk factors for, Helicobacter pylori infection among 3194 asymptomatic subjects in 17 populations. Gut. 34:1993;1672-1676.
3. Weaver L., Thomas J., Pediatric Gastroenterology. In: Pounder, R.E., editor, Recent Advances in Gastroenterology. Edinburgh: Churchill Livingstone, 1994. p. 23-41.
4. Sonnenberg A., Peptic Ulcer. In: Everhart, E., editor, Digestive Diseases in the United States: Epidemiology and Impact, NIH publication No. 94-1447. Washington, DC: Government Printing Office, 1994. p. 359-407.
5. Lee A. Helicobacter pylori: the unsuspected and unlikely global gastroduodenal pathogen. International Journal Infectious Disease. 1:1996;47-56.
6. Chen M., Lee A., Hazell S. Immunization against helicobacter infection in a mouse/Helicobacter felis model. Lancet. 339:1992;1120-1121.
7. Czinn S.J., Cai A., Nedrud J.G. Protection of germ-free mice from infection by Helicobacter felis after active oral or passive IgA immunization. Vaccine. 11:1993;637-642.
8. Ferrero R.L., Thiberge J.-M., Huerre M., Labigne A. Recombinant antigens prepared from the urease subunits of Helicobacter spp.: evidence of protection in a mouse model of gastric infection. Infection and Immunity. 62:1994;4981-4989.
9. Ferrero R.L., Thiberge J.-M., Kansau I., Wuscher N., Huerre M., Labigne A. The GroES homolog of Helicobacter pylori confers protective immunity against mucosal infection in mice. Proceedings National Academy of Sciences USA. 92:1995;6499-6503.
10. Lee C.K., Weltzin R., Thomas W.D., Kleanthous H., Ermak T.H., Soman G., Hill J.E., Ackerman S.K., Monath T.P. Oral immunization with recombinant Helicobacter pylori urease induces secretory IgA antibodies and protects mice from challenge with Helicobacter felis. Journal Infectious Diseases. 172:1995;161-172.
11. Marchetti M., Arico B., Burroni D., Figura N., Rappuoli R., Ghiara P. Development of a mouse model of Helicobacter pylori infection that mimic human disease. Science. 267:1995;1655-1658.
12. Michetti P., Corthesy-Theulaz I., Davin C., Haas R., Vaney A.-C., Heitz M., Bille J., Kraenhenbuhl J.-P., Saraga E., Blum A.L. Immunization of Balb/c mice against Helicobacter felis infection with Helicobacter pylori urease. Gastroenterology. 107:1994;1002-1011.
13. Corthesy-Theulaz I., Porta N., Glauser M., Saraga E., Vaney A.-C., Haas R., Kraenhenbuhl J.-P., Blum A.L., Michetti P. Oral immunization with Helicobacter pylori urease B subunit as a treatment against Helicobacter infection in mice. Gastroenterology. 109:1995;115-121.
14. Doidge C., Gust I., Lee A., Buck F., Hazell S., Manne U. Therapeutic immunization against helicobacter infection. Lancet. 343:1994;914-915.
15. Kleanthous H., Ermak T., Pappo J., Lee C., Monath T. Oral immunization with recombinant Helicobacter pylori urease apoenzyme in the treatment of Helicobacter infection. Gut. 37:1995;A94.
16. Cuenca R., Blanchard T.G., Czinn S.J., Nedrud J.G., Monath T.P., Lee C.K., Redline R.W. Therapeutic immunization against Helicobacter mustelae in naturally infected ferrets. Gastroenterology. 110:1996;1770-1775.
17. Schutze K., Hentschel E., Dragosics B., Hirschl A.M. Helicobacter pylori reinfection with identical organisms: transmission by the patients' spouses. Gut. 36:1995;831-833.
18. Gilman R.H., Leon-Barua R., Ramirez-Ramos A., Recavarren-Arce S., Watanabe J. Rapid recurrence of Helicobacter pylori infection in Peruvian patients after eradication therapy. Proceedings Clinical Infectious Disease Journal, in press.
19. Baskerville A., Newell D.G. Naturally occurring chronic gastritis and C. pylori infection in the rhesus monkey: a potential model for gastritis in man. Gut. 29:1988;465-472.
20. Drazek E.S., Dubois A., Holmes R.K. Characterization and presumptive identification of Helicobacter pylori isolates from rhesus monkeys. Journal Clinical Microbiology. 32:1994;1799-1804.
21. Dubois A., Fiala N., Heman-Ackah L., Drazek E., Tarnawski A., Fishbein W., Perez-Perez G., Blaser M. Natural gastric infection with Helicobacter pylori in monkeys: a model for spiral bacteria infection in humans. Gastroenterology. 106:1994;1405-1417.
22. Dubois A., Tarnawski A., Newell D., Fiala N., Dabros W., Stachura J., Krivan H., Heman-Ackah L. Gastric injury and invasion of parietal cells by spiral bacteria in rhesus monkeys. Are gastritis and hyperchlorhydria infectious diseases? Gastroenterology. 100:1991;884-891.
23. Newell D.G., Hudson M.J., Baskerville A. Isolation of a gastric campylobacter-like organism from the stomach of four rhesus monkeys, and identification as Campylobacter pylori. Journal Medical Microbiology. 27:1988;41-44.
24. Harris P.R., Mobley H.L.T., Perez-Perez G.I., Blaser M.J., Smith P.D. Helicobacter pylori urease is a potent stimulus of mononuclear phagocyte activation and inflammatory cytokine production. Gastroenterology. 111:1996;419-425.
25. Ermak T.H., Ding R., Ekstein B., Hill J., Myers G.A., Lee C.K., Pappo J., Kleanthous H.K., Monath T.P. Gastritis in urease-immunized mice after Helicobacter felis challenge may be due to residual bacteria. Gastroenterology. 113:1997;1118-1128.
26. Dubois A., Fiala N., Weichbrod R.H., Ward G.S., Nix M., Mehlman P.T., Taub D.M., Perez-Perez G.I., Blaser M.J. Seroconversion of H. pylori gastric infection in socially-housed nonhuman primates (Macaca mulatta). Gastroenterology. 104:1993;73A.
27. McNulty C.A.M., Dent J.C., Uff J.C., Gear M.W.L., Wilkinson S.P. Detection of Campylobacter pylori by the biopsy urease test: an assessment in 1445 patients. Gut. 30:1989;1058-1062.
28. Michetti P., Kreiss C., Kotloff K., Porta N., Blanco J., Bachman D., Saldinger P., Corthesy-Theulaz I., Losonsky G., Nichols R., Stolte M., Monath T., Ackerman S., Blum A. Oral immunization of H. pylori-infected adults with recombinant urease and LT adjuvant. Gastroenterology. 112:1997;A1042.
29. Kleanthous H., Myers G., Georgakopoulos K., Tibbitts T., Ingrassia J., Gray H., Ding R., Zhang Z.-z., Lei W.-d., Nichols R., Lee C., Ermak T., Monath T. Rectal and intranasal immunizations with recombinant urease induce distinct local and serum immune responses in mice and protect against Helicobacter pylori infection. Infection and Immunity. 66:1998;2879-2886.
30. Ermak T., Giannasca P., Nichols R., Myers G., Nedrud J., Lee C., Weltzin R., Kleanthous H., Monath T., MHC-Class II but not MHC-Class I or B cell responses are required for vaccine-induced protection against murine Helicobacter pylori infection. In: Third International Workshop on Pathogenesis and Host Response in Helicobacter Infections. Helsingor, 1998.
31. Atherton J.C., Tham K.T., Peek R.M., Cover T.L., Blaser M.J. Density of Helicobacter pylori infection in vivo as assessed by quantitative culture and histology. Journal Infectious Diseases. 174:1996;552-556.
32. Myers G., Ermak T., Georgakopoulos K., Tibbitts T., Bakios J., Gray H., Pappo J., Kleanthous H., Lee C.K., Monath T. Oral immunization with recombinant urease confers long-lasting immunity. Gut. 39:1996;A44.
33. Radcliff F.J., Chen M., Lee A. Protective immunization against Helicobacter stimulates long-term immunity. Vaccine. 14:1996;780-784.