Inhibition of caspase activity prevents CD95-mediated hepatic microvascular perfusion failure and restores kupffer cell clearance capacity

FASEB Journal

Volumn 13, Issue 10, 1999, Pages 1239-1248

  Wanner, Guido A ^a   Mica, Ladislav ^a   Wanner Schmid, Elisabeth ^a   Kolb, Stefan A ^a   Hentze, Hannes ^b   Trentz, Otmar ^a   Ertel, Wolfgang ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

Apoptosis; Cysteine protease; Hepatic microcirculation; Liver failure

Indexed keywords

CASPASE; CASPASE INHIBITOR; FAS ANTIGEN; IMMUNOGLOBULIN G; LIVER ENZYME;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; KUPFFER CELL; LEUKOCYTE ACTIVATION; LIVER DYSFUNCTION; LIVER PERFUSION; LIVER SINUSOID; MALE; MICROCIRCULATION; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; TISSUE NECROSIS;

ANIMALIA; MURINAE;

EID: 0032999182     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.13.10.1239     Document Type: Article

References (53)

1. Baue, A. E. (1994) Multiple organ failure, multiple organ dysfunction syndrome, and the systemic inflammatory response syndrome - where do we stand? Shock 2, 385-397
2. Deitch, E. A. (1992) Multiple organ failure. Pathophysiology and potential future therapy. Ann. Surg. 216, 117-134
3. Livingston, D. H., and Deitch, E. A. (1995) Multiple organ failure: a common problem in surgical intensive care unit patients. Ann. Med. 27, 13-20
4. Shakil, A. O., Dvorchik, I., Fung, J. J., and Rakela, J. (1997) Liver transplantation for acute liver failure: outcome analysis. J. Viral Hepat. 4, 107-110
5. Williams, R. (1996) Classification, etiology, and considerations of outcome in acute liver failure. Semin. Liver Dis. 16, 343-348
6. Feldmann, G. (1997) Liver apoptosis. J. Hepatol. 26, 1-11
7. Leist, M., Gantner, F., Künstle, G., and Wendel, A. (1998) Cytokine-mediated hepatic apoptosis. Rev. Physiol. Biochem. Pharmacol. 133, 109-155
8. Williams, G. T., and Smith, C. A. (1993) Molecular regulation of apoptosis: genetic controls on cell death. Cell 74, 777-779
9. Kondo, T., Suda, T., Fukuyama, H., Adachi, M., and Nagata, S. (1997) Essential roles of the Fas ligand in the development of hepatitis. Nature Med. 3, 409-413
10. Ksontini, R., Tannahill, C. L., Colagiovanni, D. B., Edwards, C. K., III, Abouhamze, Z., Vauthey, J. N., Copeland, E. M., III, Moldawer, L. L., and MacKay S. L. D. (1997) Activation of the Fas/Fas ligand pathway induces a tumor necrosis factor-α response that attenuates Fas ligand-mediated liver injury. Surg. Forum 48, 58-60
11. Leist, M., Gantner, F., Bohlinger, I., Tiegs, G., Germann, P. G., and Wendel, A. (1995) Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models. Am. J. Pathol. 146, 1220-1234
12. Jaeschke, H., Fisher, M. A., Lawson, J. A., Simmons, C. A., Farhood, A., and Jones, D. A. (1998) Activation of caspase 3 (CPP32)-like proteases is essential for TNF-α-induced hepatic parenchymal cell apoptosis and neutrophil-mediated necrosis in a murine endotoxin shock model. J. Immunol. 160, 3480-3486
13. Gao, W., Bentley, R. C., Madden, J. E., and Clavien, P. A. (1998) Apoptosis of sinusoidal endothelial cells is a critical mechanism of preservation injury in rat liver transplantation. Hepatology 27, 1652-1660
14. Müschen, M., Warskulat, U., Douillard, P., Gilbert, E., and Häussinger, D. (1998) Regulation of CD95 (Apo-1/Fas) receptor and ligand expression by lipopolysaccharide and dexamethasone in parenchymal and nonparenchymal rat liver cells. Hepatology 27, 200-208
15. Galle, P. R., and Strand, S. (1998) Immune evasion by tumors: involvement of the CD95 (APO-1/Fas) system and its clinical implications. Mol. Med. Today 4, 63-68
16. Galle, P. R., Krammer, P. H., (1998) CD95-induced apoptosis in human liver disease. Semin. Liver Dis. 18, 141-151
17. Schneider, P., Holler, N., Bodmer, J. L., Hahne, M., Frei, K., Fontana, A., and Tschopp, J. (1998) Conversion of membrane-bound Fas (CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity. J. Exp. Med. 187, 1205-1213
18. Lawson, J. A., Fisher, M. A., Simmons, C. A., Farhood, A., and Jaeschke, H. (1998) Parenchymal cell apoptosis as a signal for sinusoidal sequestration and transendothelial migration of neutrophils in murine models of endotoxin and Fas-antibody-induced liver injury. Hepatology 28, 761-767
19. Ksontini, R., Colagiovanni, D. B., Josephs, M. D., Edwards, C. K., III, Tannahill, C. L., Solorzano, C. C., Norman, J., Denham, W., Clare-Salzler, M., MacKay, S. L. D., and Moldawer, L. L. (1998) Disparate roles for TNF-α and Fas ligand in concanavalin A-induced hepatitis. J. Immunol. 160, 4082-4089
20. Nagata, S. (1997) Apoptosis by death factor. Cell 88, 355-365
21. Watanabe-Fukunaga, R., Brannan, C. I., Itoh, N., Yonehara, S., Copeland, N. G., Jenkins, N. A., and Nagata, S. (1992) The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen. J. Immunol. 148, 1274-1279
22. Cascino, I., Fiucci, G., Papoff, G., and Ruberti, G. (1995) Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing. J. Immunol. 154, 2706-2713
23. Cheng, J., Zhou, T., Liu, C., Shapiro, J. P., Brauer, M. J., Kiefer, M. C., Barr, P. J., and Mountz, J. D. (1994) Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. Science 263, 1759-1762
24. Medema, J. P., Scaffidi, C., Kischkel, F. C., Shevchenko, A., Mann, M., Krammer, P. H., and Peter, M. E. (1997) FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J. 16, 2794-2804
25. Chinnaiyan, A. M., Tepper, C. G., Seldin, M. F., O'Rourke, K., Kischkel, F. C., Hellbardt, S., Krammer, P. H., Peter, M. E., and Dixit, V. M. (1996) FADD/MORT1 is a common mediator of CD95 (Fas/APO-1 ) and tumor necrosis factor receptor-induced apoptosis. J. Biol. Chem. 271, 4961-4965
26. Chinnaiyan, A. M., O'Rourke, K., Tewari, M., and Dixit, V. M. (1995) FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81, 505-512
27. Muzio, M., Chinnaiyan, A. M., Kischkel, K., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., Mann, M., Krammer, P. H., Peter, M. F., and Dixit, V. M. (1996) FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/Apo-1) death-inducing signaling complex. Cell 85, 817-827
28. Ashkenazi, A., and Dixit, V. M. (1998) Death receptors: signaling and modulation. Science 281, 1305-1308
29. Cohen, G. M. (1997) Caspases: the executioners of apoptosis. Biochem. J. 326, 1-16
30. Zhivotovsky, B., Burgess, D. H., Vanags, D. M., and Orrenius, S. (1997) Involvement of cellular proteolytic machinery in apoptosis. Biochem. Biophys. Res. Commun. 230, 481-488
31. Thornberry, N. A., and Lazebnik, Y. (1998) Caspases: enemies within. Science 281, 1312-1316
32. Takahashi, A., Kobayashi, S., Yonehara, S., Sawai, H., Okazaki, T., Yamamoto, K., Sasada, M., and Hirata, H. (1998) Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis. J. Exp. Med. 187, 587-600
33. Ogasawara, J., Watanabe-Fukunaga, R., Adachi, M., Matsuzawa, A., Kasugai, T., Kitamura, Y., Itoh, N., Suda, T., and Nagata, S. (1993) Lethal effect of the anti-Fas antibody in mice. Nature (London) 364, 806-809
34. Jones, R. A., Johnson, V. L., Buck, N. R., Dobrota, M., Hinton, R. H., Chow, S. C., and Kass, G. E. N. (1998) Fas-mediated apoptosis in mouse hepatocytes involves the processing and activation of caspases. Hepatology 27, 1632-1642
35. Rodriguez, I., Matsuura, K., Ody, C., Nagata, S., and Vassalli, P. (1996) Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death. J. Exp. Med. 184, 2067-2072
36. Suzuki, A. (1998) The dominant role of CPP32 subfamily in Fas-mediated hepatitis. Proc. Soc. Exp. Biol. Med. 217, 450-454
37. Ni, R., Tomita, Y., Matsuda K., Ichihara, A., Ishimura, K., Ogasawara, J., and Nagata, S. (1994) Fas-mediated apoptosis in primary cultured mouse hepatocytes. Exp. Cell Res. 215, 332-337
38. Takehara, T., Hayashi, N., Mita, E., Kanto, T., Tatsumi, T., Sasaki, Y., Kasahara, A., and Hori, M. (1998) Delayed Fas-mediated hepatocyte apoptosis during liver regeneration in mice: hepatoprotective role of TNF-α. Hepatology 27, 1643-1651
39. Takei, Y., Kawano, S., Nishimura, Y., Goto, M., Nagai, H., Chen, S. S., Omae, A., Fusamoto, H., Kamada, T., Ikeda, K., Kawada, N., and Kaneda, K. (1995) Apoptosis: a new mechanism of endothelial and Kupffer cell killing. J. Gastroenterol. Hepatol. 10, Suppl. 1, S65-S67
40. MacPhee, P., Schmidt, E. E., and Groom, A. C. (1993) Organization and flow in the liver microcirculation. In Progress in Applied Microcirculation. Microcirculation and Hepatobiliary Function (Messmer, K., and Menger, M. D., eds) Vol. 19, pp. 52-73, S. Karger AG, Basel, Switzerland
41. Menger, M. D., Vollmar, B., Glasz, J., Post, S., Messmer, K. (1993) Microcirculatory manifestations of hepatic ischemia/ reperfusion injury. In Progress in Applied Microcirculation. Microcirculation and Hepatobiliary Function (Messmer, K., and Menger, M. D., eds) Vol. 19, pp. 106-124, S. Karger AG, Basel, Switzerland
42. Vollmar, B., Messner, S., Wanner, G. A., Hartung, T., and Menger, M. D. (1997) Immunomodulatory action of G-CSF in a rat model of endotoxin-induced liver injury: an intravital microscopic analysis of Kupffer cell and leukocyte response. J. Leukoc. Biol. 62, 710-718
43. Post, S., Gonzalez, A. P., Palma, P., Rentsch, M., Stiehl, A., and Menger, M. D. (1992) Assessment of hepatic phagocytic activity by in vivo microscopy after liver transplantation in the rat. Hepatology 16, 803-809
44. Vollmar, B., Rüttinger, D., Wanner, G. A., Leiderer, R., and Messmer, K. (1996) Modulation of Kupffer cell activity by gadolinium chloride in endotoxemic rats. Shock 6, 434-441
45. Bauer, I., Bauer, M., Pannen, B. H., Leinwand, M. J., Zhang, J. X., and Clemens, M. G. (1995) Chronic ethanol consumption exacerbates liver injury following hemorrhagic shock: role of sinusoidal perfusion failure. Shock 4, 324-331
46. Thornberry, N. A. (1994) Interleukin-1β converting enzyme. Methods Enzymol. 244, 615-631
47. Raff, M. C. (1992) Social controls on cell survival and cell death. Nature (London) 356, 397-400
48. Wyllie, A. H., Kerr, J. F. R., and Currie, A. R. (1980) Cell death: the significance of apoptosis. Int. Rev. Cytol. 68, 251-306
49. Sarin, A., Wu, M.L, and Henkart, P. A. (1996) Different interleukin-1β converting enzyme (ICE) family protease requirements for the apoptotic death of T lymphocytes triggered by diverse stimuli. J. Exp. Med. 184, 2445-2450
50. Margolin, N., Raybuck, S. A., Wilson, K. P., Chen, W., Fox, T., Gu, Y., and Livingston, D. J. (1997) Substrate and inhibitor specificity of interleukin-1β-converting enzyme and related caspases. J. Biol. Chem. 272, 7223-7228
51. Vercammen, D., Brouckaert, G., Denecker, G., Van de Craen, M., Declercq, W., Fiers, W., and Vandenabeele, P. (1998) Dual signaling of the Fas receptor: Initiation of both apoptotic and necrotic cell death pathways. J. Exp. Med. 188, 919-930
52. Nicholson, D. W. (1996) ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis. Nat. Biotech. 14, 297-301
53. Villa, P., Kaufmann, S. H., and Earnshaw, W. C. (1997) Caspases and caspase inhibitors. Trends Biochem. Sci. 22, 388-393