Cancer gene therapy using a novel adeno-associated virus vector expressing human wild-type p53

Gene Therapy

Volumn 4, Issue 7, 1997, Pages 675-682

  Qazilbash, M H ^a   Xiao, X ^b   Seth, P ^a   Cowan, K H ^a   Walsh, C E ^c  

^a NATIONAL CANCER INSTITUTE   (United States)

^b CELL GENESYS INC   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Cell cycle arrest; Gene therapy; P53; Recombinant adeno associated virus

Indexed keywords

ACTIN; COMPLEMENTARY DNA; PROTEIN P53; VIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER; CANCER CELL; CANCER INHIBITION; CANCER THERAPY; CANCER TRANSPLANTATION; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL GROWTH; CELL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; GENE DELETION; GENE THERAPY; GENE TRANSFER; GENETIC ENGINEERING; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOBLOTTING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENO-ASSOCIATED VIRUS; ANIMALIA;

EID: 0030840093     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300444     Document Type: Article

References (38)

1. Bishop JM. The molecular genetics of cancer. Science 1992; 235: 305-311.
2. Chang F, Syrjanen S, Syrjanen K. Implications of the p53 tumor suppressor gene in clinical oncology. J Clin Oncol 1995; 13: 1009-1022.
3. Katayose D et al. Cytotoxic effects of adenovirus-mediated wild-type p53 protein expression in normal and tumor mammary epithelial cells. Clin Cancer Res 1995; 1: 889-897.
4. Katayose D, Wersto R, Cowan KH, Seth P. Effects of a recombinant adenovirus expressing WAF1/Cip1 on cell growth, cell cycle, and apoptosis. Cell Growth Diff 1995; 6: 1207-1212.
5. El Deiry WS et al. WAF1/Cip1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res 1994; 54: 1169-1174.
6. Miyashita T et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 1994; 9: 1799-1805.
7. Miyashita T, Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995; 80: 293-299.
8. Cai DW et al. Stable expression of the wild-type p53 gene in human lung cancer cells after retrovirus-mediated gene transfer. Hum Gene Ther 1993; 4: 617-624.
9. Nienhuis AW, Walsh CE, Liu JM. Viruses as therapeutic gene transfer vectors. In: NS Young (ed). Viruses and Bone Marrow. Marcel Dekker. New York, 1993, pp 353-414.
10. Berns KI, Bohenzky RA. Adeno-associated viruses: an update. Adv Virus Res 1987; 32: 243-306.
11. Kotin RM, Linden RM, Berns KI. Characterization of a preferred site on human chromosome 19q for integration of adeno-associated virus DNA by nonhomologous recombination. EMBO J 1992; 11: 5071-5078.
12. Kaplitt MG et al. Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain. Nat Genet 1994; 8: 148-154.
13. McCown TJ et al. Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector. Brain Res 1996; 713: 99-107.
14. Takahashi T et al. p53: A frequent target for genetic abnormalities in lung cancer. Science 1989; 246: 491-494.
15. Goodman S et al. Recombinant adeno-associated virus mediated gene transfer into hematopoietic progenitor cells. Blood 1994; 84: 1492-1500.
16. Peter M, Herskowitz I. Joining the complex: cyclin-dependent kinase inhibitory proteins and the cell cycle. Cell 1994; 79: 181-184.
17. Harper JW et al. The p21 cdk-interacting protein cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1993; 75: 805-816.
18. Momand J et al. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992; 69: 1237-1245.
19. Yang Z et al. The p21 cyclin-dependent kinase inhibitor suppresses tumorigenicity in vivo. Nature Med 1995; 1: 1052-1056.
20. Yang E, Korsemeyer SJ. Molecular thanatopsis: a discourse on the bcl-2 family and cell death. Blood 1996; 88: 386-401.
21. Haldar S et al. Down-regulation of bcl-2 by p53 in breast cancer cells. Cancer Res 1994; 54: 2095-2097.
22. Mesnil M et al. Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins. Proc Natl Acad Sci USA 1996; 93: 1831-1835.
23. Freeman SM et al. The bystander effect': tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res 1993; 53: 5274-5283.
24. Xu M et al. Parenteral gene therapy with p53 inhibits human breast tumors in vivo through a bystander mechanism without evidence of toxicity. Hum Gene Ther 1997; 8: 177-185.
25. Sprecher-Goldberger S et al. Complement-fixation antibodies to adeno-associated viruses, adenoviruses, cytomegaloviruses and herpes simplex viruses in patients with tumors and in control individuals Am J Epidemiol 1971; 94: 351-358.
26. Cukor G et al. Effect of adeno-associated virus on cancer expression by herpes virus-transformed hamster cells. J Natl Cancer Inst 1975; 55: 957-959.
27. Fujiwara T et al. Therapeutic effect of a retroviral wild-type p53 expression vector in an orthotopic lung cancer model. J Natl Cancer Inst 1994; 86: 1458-1462.
28. Roth JA et al. Retrovirus-mediated wild-type p53 gene transfer to rumors of patients with lung cancer. Nature Med 1996, 2: 985-991.
29. Willis KN et al. Development and characterization of recombinant adenovirus encoding human p53 for gene therapy of cancer. Hum Gene Ther 1994; 5: 1079-1088.
30. Zhang WW et al. Safety evaluation of AdCMV-p53 in vitro and in vivo. Hum Gene Ther 1995; 6: 155-164.
31. Fujiwara T et al. Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene. Cancer Res 1994; 54: 2287-2291.
32. Xiao X, Li J, Samulski RJ. Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector. J Virol 1996; 70: 8098-8108.
33. Walsh CE et al. Phenotypic correction of Fanconi anemia in human hematopoietic cells with a recombinant adeno-associated virus vector. J Clin Invest 1994; 94: 1440-1448.
34. Kearns WG et al. Recombmant adeno-associated virus (AAV-CFTR) vectors do not integrate in a site-specific fashion in an immortalized epithelial cell line. Gene Therapy 1996; 3: 748-755.
35. Gudas J et al. Expression of wild-type p53 during the cell cycle in normal human mammary epithelial cells. Cell Growth Diff 1994; 5: 295-304.
36. Skehan P et al. New colorimetric cytotoxicity assay for anticancer drug screening. J Natl Cancer Inst 1990; 82: 1107-1112.
37. Adam L, Crepin M, Savin C, Israel L. Sodium phenylacetate induces growth inhibition and bcl-2 down-regulation and apoptosis in MCF7 ras cells in vitro and in nude mice. Cancer Res 1995; 55: 5156-5160.
38. Costa M et al. Transformation in recurrent ovarian granulosa cell tumors: Ki67(MIB-1) and p53 immunohistochemistry demonstrates a possible molecular basis for the poor histopathologic prediction of clinical behavior. Hum Path 1996; 3: 274-281.