Ribonuclease P protein structure: Evolutionary origins in the translational apparatus

Science

Volumn 280, Issue 5364, 1998, Pages 752-755

  Stams, Travis ^a   Niranjanakumari, S ^b   Fierke, Carol A ^b   Christianson, David W ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RIBONUCLEASE P;

ARTICLE; BACILLUS SUBTILIS; BINDING SITE; CONFORMATIONAL TRANSITION; MOLECULAR EVOLUTION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN RNA BINDING; TRANSLATION REGULATION;

BACILLUS SUBTILIS; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENDORIBONUCLEASES; EVOLUTION, MOLECULAR; MAGNESIUM; MODELS, MOLECULAR; PEPTIDE ELONGATION FACTOR G; PEPTIDE ELONGATION FACTORS; PROTEIN BIOSYNTHESIS; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; RIBONUCLEASE P; RIBOSOMAL PROTEINS; RNA, BACTERIAL; RNA, CATALYTIC; ZINC;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); PROKARYOTA;

EID: 0032076249     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.280.5364.752     Document Type: Article

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46. Figures 1A and 3 were prepared with MOLSCRIPT [P. Kraulis, J. Appl. Crystallogr. 24, 946 (1991)] and Raster3D [D. J. Bacon and W. F. Anderson, J. Mol. Graph. 6, 219 (1988); E. A. Merritt and M. E. P. Murphy, Acta Crystallogr. D50, 869 (1994)].
47. Figures 1A and 3 were prepared with MOLSCRIPT [P. Kraulis, J. Appl. Crystallogr. 24, 946 (1991)] and Raster3D [D. J. Bacon and W. F. Anderson, J. Mol. Graph. 6, 219 (1988); E. A. Merritt and M. E. P. Murphy, Acta Crystallogr. D50, 869 (1994)].
48. DENZO, SCALEPACK, MLPHARE [Z. Otwinowski, in Proceedings of the CCP4 Study Weekend, L. Sawyer, N. Issac, S. Borley, Eds. (SERC Daresbury, Daresbury, UK), pp. 56-62 (1993)]; Z. Otwinowski and W. Minor, Methods Enzymol. 276, 307 (1997); Collaborative Computational Project, Number 4, Acta Crystallogr. D50, 760 (1994)], SOLOMON [J. P. Abrahams and A. G. W. Leslie, ibid. D52, 30 (1996)], X-PLOR [A. T. Brünger, J. Kuriyan, M. Karplus, Science 235, 458 (1987)], and O [T. A. Jones, J.-Y. Zou, S. W. Cowan, M. Kjeldgaard, Acta. Crystallogr. A47, 110 (1991)].
49. DENZO, SCALEPACK, MLPHARE [Z. Otwinowski, in Proceedings of the CCP4 Study Weekend, L. Sawyer, N. Issac, S. Borley, Eds. (SERC Daresbury, Daresbury, UK), pp. 56-62 (1993)]; Z. Otwinowski and W. Minor, Methods Enzymol. 276, 307 (1997); Collaborative Computational Project, Number 4, Acta Crystallogr. D50, 760 (1994)], SOLOMON [J. P. Abrahams and A. G. W. Leslie, ibid. D52, 30 (1996)], X-PLOR [A. T. Brünger, J. Kuriyan, M. Karplus, Science 235, 458 (1987)], and O [T. A. Jones, J.-Y. Zou, S. W. Cowan, M. Kjeldgaard, Acta. Crystallogr. A47, 110 (1991)].
50. DENZO, SCALEPACK, MLPHARE [Z. Otwinowski, in Proceedings of the CCP4 Study Weekend, L. Sawyer, N. Issac, S. Borley, Eds. (SERC Daresbury, Daresbury, UK), pp. 56-62 (1993)]; Z. Otwinowski and W. Minor, Methods Enzymol. 276, 307 (1997); Collaborative Computational Project, Number 4, Acta Crystallogr. D50, 760 (1994)], SOLOMON [J. P. Abrahams and A. G. W. Leslie, ibid. D52, 30 (1996)], X-PLOR [A. T. Brünger, J. Kuriyan, M. Karplus, Science 235, 458 (1987)], and O [T. A. Jones, J.-Y. Zou, S. W. Cowan, M. Kjeldgaard, Acta. Crystallogr. A47, 110 (1991)].
51. DENZO, SCALEPACK, MLPHARE [Z. Otwinowski, in Proceedings of the CCP4 Study Weekend, L. Sawyer, N. Issac, S. Borley, Eds. (SERC Daresbury, Daresbury, UK), pp. 56-62 (1993)]; Z. Otwinowski and W. Minor, Methods Enzymol. 276, 307 (1997); Collaborative Computational Project, Number 4, Acta Crystallogr. D50, 760 (1994)], SOLOMON [J. P. Abrahams and A. G. W. Leslie, ibid. D52, 30 (1996)], X-PLOR [A. T. Brünger, J. Kuriyan, M. Karplus, Science 235, 458 (1987)], and O [T. A. Jones, J.-Y. Zou, S. W. Cowan, M. Kjeldgaard, Acta. Crystallogr. A47, 110 (1991)].
52. DENZO, SCALEPACK, MLPHARE [Z. Otwinowski, in Proceedings of the CCP4 Study Weekend, L. Sawyer, N. Issac, S. Borley, Eds. (SERC Daresbury, Daresbury, UK), pp. 56-62 (1993)]; Z. Otwinowski and W. Minor, Methods Enzymol. 276, 307 (1997); Collaborative Computational Project, Number 4, Acta Crystallogr. D50, 760 (1994)], SOLOMON [J. P. Abrahams and A. G. W. Leslie, ibid. D52, 30 (1996)], X-PLOR [A. T. Brünger, J. Kuriyan, M. Karplus, Science 235, 458 (1987)], and O [T. A. Jones, J.-Y. Zou, S. W. Cowan, M. Kjeldgaard, Acta. Crystallogr. A47, 110 (1991)].
53. DENZO, SCALEPACK, MLPHARE [Z. Otwinowski, in Proceedings of the CCP4 Study Weekend, L. Sawyer, N. Issac, S. Borley, Eds. (SERC Daresbury, Daresbury, UK), pp. 56-62 (1993)]; Z. Otwinowski and W. Minor, Methods Enzymol. 276, 307 (1997); Collaborative Computational Project, Number 4, Acta Crystallogr. D50, 760 (1994)], SOLOMON [J. P. Abrahams and A. G. W. Leslie, ibid. D52, 30 (1996)], X-PLOR [A. T. Brünger, J. Kuriyan, M. Karplus, Science 235, 458 (1987)], and O [T. A. Jones, J.-Y. Zou, S. W. Cowan, M. Kjeldgaard, Acta. Crystallogr. A47, 110 (1991)].
54. We thank J. D. Cox, Z. F. Kanyo, J. C. Kurz, C. A. Lesburg, P. B. Moore, and S. W. White for helpful discussions during the course of this investigation. Supported by grant GM55387 from the National Institutes of Health. T.S. was supported by a Lynch Fellowship. Atomic coordinates have been deposited in the Brookhaven Protein Data Bank (accession code 1A6F).