Mouse models of chronic lung infection with Pseudomonas aeruginosa: Models for the study of cystic fibrosis

Pediatric Pulmonology

Volumn 30, Issue 5, 2000, Pages 413-424

  Stotland, Peter K ^a   Radzioch, Danuta ^a   Stevenson, Mary M ^a  

^a MONTREAL GENERAL HOSPITAL   (Canada)

Author keywords

Animal models; Cystic fibrosis; Cytokines; Inflammation; Lung infection; Pseudomonas aeruginosa

Indexed keywords

CYCLIC AMP; CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 11; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 8; TRANSMEMBRANE CONDUCTANCE REGULATOR;

CLINICAL FEATURE; CYSTIC FIBROSIS; DISEASE COURSE; DISEASE PREDISPOSITION; GENETIC ANALYSIS; IMMUNE RESPONSE; INBRED STRAIN; KNOCKOUT MOUSE; LUNG INFECTION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; REVIEW; STRAIN DIFFERENCE;

ANIMALS; CHRONIC DISEASE; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CYTOKINES; DISEASE MODELS, ANIMAL; FORECASTING; LUNG; LUNG DISEASES; MICE; MICE, KNOCKOUT; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS;

EID: 0033765710     PISSN: 87556863     EISSN: None     Source Type: Journal    
DOI: 10.1002/1099-0496(200011)30:5<413::AID-PPUL8>3.0.CO;2-9     Document Type: Review

References (89)

1. Cystic fibrosis
2. Clinical features of cystic fibrosis patients with rare genotypes in Saguenay Lac-Saint-Jean (Quebec, Canada)
3. Cystic fibrosis of the pancreas and its relation to celiac disease: A clinical and pathologic study
4. The genetics of cystic fibrosis lung disease
5. Cystic fibrosis
6. The role of Pseudomonas aeruginosa in the pathogenesis of lung disease in cystic fibrosis - More questions than answers
7. Pulmonary immunity to Pseudomonas aeruginosa
8. Pathogenesis of cystic fibrosis
9. Inflammation in the lung in cystic fibrosis: A vicious cycle that does more harm than good?
10. Immunopathogenesis of cystic fibrosis lung disease
11. Current understanding of the inflammatory process in cystic fibrosis: Onset and etiology
12. Early pulmonary inflammation in infants with cystic fibrosis
13. Lower respiratory infection and inflammation in infants with newly diagnosed cystic fibrosis
14. Lower airway inflammation in infants and young children with cystic fibrosis
15. Effect of high-dose ibuprofen in patients with cystic fibrosis
16. Evidence for periciliar liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airway disease
17. Loss of CFTR chloride channels alters salt absorption by cystic fibrosis airway epithelial cells in vitro
18. Cystic fibrosis epithelial cells have a receptor for pathogenic bacteria on their apical surface
19. Role of mutant CFTR in hypersusceptibility of cystic fibrosis patients to lung infections
20. Independent genetic determinants of pancreatic and pulmonary status in cystic fibrosis
21. Correlation between genotype and phenotype in patients with cystic fibrosis. The cystic fibrosis genotype-phenotype consortium
22. Genotype-phenotype relationship in cystic fibrosis: Results from the study of monozygotic and dizygotic twins with cystic fibrosis
23. Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor
24. Potential of preventing Pseudomonas aeruginosa lung infections in cystic fibrosis patients: Experimental studies in animals
25. Role of agar beads in the pathogenicity of Pseudomonas aeruginosa in the rat respiratory tract
26. A rat model of chronic respiratory infection with Pseudomonas aeruginosa
27. Induction of experimental chronic Pseudomonas aeruginosa lung infection with P. aeruginosa entrapped in alginate microspheres
28. Protective immunization against chronic Pseudomonas aeruginosa pulmonary infection in rats
29. Studies on the ability of alginate to act as a protective immunogen against infection with Pseudomonas aeruginosa in animals
30. Chronic Pseudomonas aeruginosa lung infection in normal and athymic rats
31. Interferongamma (IFN-γ) treatment decreases the inflammatory response in chronic Pseudomonas aeruginosa pneumonia in rats
32. Protection against mucoid Pseudomonas aeruginosa in rodent models of endobronchial infection
33. Local Pseudomonas instillation induces contralateral lung injury and plasma cytokines
34. Active immunization with lipopolysaccharide Pseudomonas antigen for chronic Pseudomonas bronchopneumonia in guinea pigs
35. Pulmonary cellular response to chronic irritation and chronic Pseudomonas aeruginosa pneumonia in cats
36. Chronic Pseudomonas aeruginosa endobronchitis in rhesus monkeys. I. Effects of pentoxifylline on neutrophil influx
37. Chronic Pseudomonas aeruginosa endobronchitis in rhesus monkeys. II. A histopathologic analysis
38. A mouse model of chronic pulmonary infection with Pseudomonas aeruginosa and Pseudomonas cepacia
39. Endobronchial inflammation following Pseudomonas aeruginosa infection in resistant and susceptible strains of mice
40. In vitro and in vivo T cell responses in mice during bronchopulmonary infection with mucoid Pseudomonas aeruginosa
41. Characterization of chronic bronchopulmonary Pseudomonas aeruginosa infection in resistant and susceptible inbred mice
42. Quantitative and qualitative differences in bronchopulmonary inflammatory cells in Pseudomonas aeruginosa-resistant and susceptible mice
43. Cytokines induce the development of functionally heterogenous T helper cell subsets
44. Role of tumor necrosis factor alpha in innate resistance to mouse pulmonary infection with Pseudomonas aeruginosa
45. Inducible nitric oxide synthase expression is reduced in cystic fibrosis murine and human airway epithelial cells
46. Decreased concentration of exhaled nitric oxide (NO) in patients with cystic fibrosis
47. Lack of inducible nitric oxide synthase in bronchial epithelium: A possible mechanism of susceptibility in infection with cystic fibrosis
48. Allotypes of α1-antitrypsin in patients with cystic fibrosis, homozygous and heterozygous for DeltaF508
49. α1-antitrypsin deficiency, emphysema, and liver disease. Genetic basis and strategies for therapy
50. Natural resistance to infection with intracellular parasites: Isolation of a candidate for Bcg
51. Human natural resistance-associated macrophage protein, cDNA cloning, chromosomal mapping, genomic organization and tissue specific expression
52. An animal model for cystic fibrosis made by gene targeting
53. Defective epithelial chloride transport in a gene-targeted mouse model of cystic fibrosis
54. Phenotypic abnormalities in long-term surviving cystic fibrosis mice
55. Cystic fibrosis in the mouse by targeted insertional mutagenesis
56. Production of a severe cystic fibrosis mutation in mice by gene targeting
57. A severe phenotype in mice with a duplication of exon 3 in the cystic fibrosis locus
58. A mouse model for the cystic fibrosis ΔF508 mutation
59. Generation and characterization of a ΔF508 cystic fibrosis mouse model
60. Cystic fibrosis mice carrying the missense mutation G551D replicate human genotype-phenotype correlations
61. Lung disease in mice with cystic fibrosis
62. A murine model for cystic fibrosis
63. The relationship of chronic mucin secretion to airway disease in normal and CFTR-deficient mice
64. Lung disease in the cystic fibrosis mouse exposed to bacterial pathogens
65. Excessive inflammatory response of cystic fibrosis mice to bronchopulmonary infection with P. aeruginosa
66. Impaired ability of Cftr knockout mice to control lung infection with P. aeruginosa
67. The innate immune system in cystic fibrosis lung disease
68. Selective up-regulation of chemokine IL-8 expression in cystic fibrosis bronchial gland cells in vivo and in vitro
69. Genestein inhibits constitutive and inducible NFkappaB activation and decreases IL-8 production by human cystic fibrosis bronchial gland cells
70. The bronchoalveolar lavage fluid of cystic fibrosis lung transplant recipients demonstrates increased IL-8 and elastase and decreased IL-10
71. Interleukin 10
72. Interleukin-10 suppresses IL-10 gene transcription by inhibiting the production of class I interferon
73. IL-10 suppresses LPS-induced KC mRNA expression via a translation-dependent decrease in mRNA stability
74. Inflammatory cytokines in cystic fibrosis lungs
75. Normal bronchial epithelial cells constitutively produce the anti-inflammatory cytokine interleukin-10, which is down-regulated in cystic fibrosis
76. Reduced IL-10 secretion by CD4+ T lymphocytes expressing mutant cystic fibrosis transmembrane conductance regulator (CFTR)
77. Nasal and bronchoalveolar lavage fluid cytokines in early cystic fibrosis
78. Bronchoalveolar lavage: Quantitation of intraalveolar fluid?
79. Bronchoalveolar lavage
80. Studies with IL-10 -/-mice: An overview
81. Neutralization of IL-10 increases survival in a murine model of Klebsiella pneumonia
82. Interleukin-10 impairs host defense in murine pneumococcal pneumonia
83. IL-10 improves lung injury and survival in Pseudomonas aeruginosa pneumonia
84. Microbial pathogenesis in cystic fibrosis - Pulmonary clearance of mucoid Pseudomonas aeruginosa and inflammation in a mouse model of repeated respiratory challenge
85. 2
86. Recombinant human IL-11 attenuates the inflammatory response through down-regulation of proinflammatory cytokine release and nitric oxide production
87. Interleukin 13 is a new human lymphokine regulating inflammatory and immune responses
88. Anti-inflammatory actions of interleukin 13: Suppression of tumor necrosis factor-α and antigen-induced leukocyte accumulation in the guinea pig lung
89. Interleukin-4 enhances pulmonary clearance of Pseudomonas aeruginosa