Selection of CD8+ T cells with highly focused specificity during viral persistence in the central nervous system

Journal of Immunology

Volumn 162, Issue 7, 1999, Pages 3905-3914

  Marten, Norman W ^a   Stohlman, Stephen A ^a   Smith Begolka, Wendy ^b   Miller, Stephen D ^b   Dimacali, Emmanuel ^a   Yao, Qin ^a   Stohl, Sheldon ^a   Goverman, Joan ^c   Bergmann, Cornelia C ^a,d  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d Dept Molec Biotech and Immunol University of Washington ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; CELL SPECIFICITY; CENTRAL NERVOUS SYSTEM; COMPLEMENTARITY DETERMINING REGION; CYTOTOXIC T LYMPHOCYTE; GENE MUTATION; GENETIC HETEROGENEITY; LYMPHOCYTE CLONE; MALE; MOUSE; MURINE HEPATITIS CORONAVIRUS; NONHUMAN; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; RNA VIRUS; SPLEEN; T LYMPHOCYTE SUBPOPULATION;

EID: 0033120987     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Rothbard, J. B., and M. L. Gefter. 1991. Interactions between immunogenic peptides and MHC proteins. Annu. Rev. Immunol. 9:527.
2. Matis, L. A. 1990. The molecular basis of T cell specificity. Annu. Rev. Immunol. 8:65.
3. Engel, I., and S. M. Hedrick. 1988. Site-directed mutations in the VDJ junctional region of a T cell receptor β chain cause changes in antigenic peptidc recognition. Cell 54:473.
4. Jorgensen, I., U. Esser, B. Fazekas de St. Groth, P. A. Reay, and M. M. Davis. 1992. Mapping T cell receptor peptide contacts by variant peptide immunization of single-chain transgenics. Nature 355:224.
5. Ding, Y.-H., K. J. Smith, D. N. Garboczi, U. Utz, W. E. Biddison, and D. C. Wiley. 1998. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids. Immunity 8:403.
6. Cole, G. A., T. L. Hogg, and D. L. Woodland. 1994. The MHC class I-restricted T cell response to Sendai virus infection in C57BL/6 mice: a single immunodominant epitope elicits an extremely diverse repertoire of T cells. Int. Immunol. 6:1767.
7. Horwitz, M. S., Y. Yanagi, and M. B. A. Oldstone. 1994. T cell receptors from virus-specific cytotoxic T lymphocytes recognizing a single immunodominant nine-amino-acid viral epitope show marked diversity. J. Virol. 68:352.
8. Doherty, P. C., S. Hou, C. F. Evans, J. L. Whitton, M. B. A. Oldstone, and M. A. Blackman. 1994. Limiting the available T cell receptor repertoire modifies acute lymphocytic choriomeningitis virus-induced immunopathology. J. Neuroimmunol. 51:147.
9. Gallimore, A., T. Dumrese, H. Hengartner, R. M. Zinkernagel, and H.-G. Rammensee. 1998. Protective immunity does not correlate with the hierarchy of virus-specific cytotoxic T cell responses to naturally processed peptides. J. Exp. Med. 187:1647.
10. Alexander-Miller, M. A., G. R. Leggatt, and J. A. Berzofsky. 1996. Selective expansion of high-and low-avidity cytotoxic T lymphocytes and efficiency for adoptive immunotherapy. Proc. Natl. Acad. Sci. USA 93:4102.
11. Salmon, M., D. Pilling, N. J. Borthwick, N. Viner, G. Janossy, P. A. Bacon, and A. N. Akbar. 1994. The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis. Eur. J. Immunol. 24:82.
12. Ahmed, R., and D. Gray. 1996. Immunological memory and protective immunity: understanding their relation. Science 272:54.
13. Efferos, R. B., J. Bennink, and P. C. Doherty. 1978. Characteristics of secondary cytotoxic T cell responses in mice infected with influenza A virus. Cell. Immunol. 36:345.
14. + naive or memory T cells. Science 276:2057.
15. Müllbacher, A., and K. Flynn. 1996. Aspects of cytotoxic T cell memory. Immunol. Rev. 150:113.
16. Maryanski, J. L., C. V. Jongeneel, P. Bucher, J.-L. Casanova, and P. R. Walker. 1996. Single-cell PCR analysis of TCR repertoires selected by antigen in vivo: high magnitude CD8 response is comprised of very few clones. Immunity 4:47.
17. Vijh, S., and E. G. Pamer. 1997. Immunodominant and subdominant CTL responses to Listeria monocytogenes infection. J. Immunol. 158:3366.
18. Bachmann, M. F., D. E. Speiser, and P. S. Ohashi. 1997. Functional maturation of an antiviral cytotoxic T cell response. J. Virol. 71:5764.
19. van der Most, R. G., A. Sette, C. Oseroff, J. Alexander, K. Murali-Krishna, L. L. Lau, S. Southwood, J. Sidney, R. W. Chestnut, M. Matloubian, and R. Ahmed. 1996. Analysis of cytotoxic T cell responses to dominant and sub-dominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection. J. Immunol. 157:5543.
20. Steven N. M., A. M. Leese, N. E. Annels, S. P. Lee, and A. B. Rickinson. 1996. Epitope focusing in the primary cytotoxic T cell response to Epstein-Barr virus and its relationship to memory. J. Exp. Med. 184:1801.
21. Silins, S. L., S. M. Cross, S. L. Elliott, S. J. Pye, S. R. Burrows, J. M. Burrows, D. J. Moss, V. P. Argaet, and I. S. Misko. 1996. Development of Epstein-Barr virus-specific memory T cell receptor clonotypes in acute infectious mononucleosis. J. Exp. Med. 184:1815.
22. Parra, B., D. R. Hinton, M. T. Lin, D. J. Cua, and S. A. Stohlman. 1997. Kinetics of cytokine mRNA expression in the central nervous system following lethal and nonlethal coronavirus-induced acute encephalomyelitis. Virology 233:260.
23. Perlman, S., and D. Ries. 1987. The astrocyte is a target cell in mice persistently infected with mouse hepatitis virus, strain JHM. Microb. Pathog. 3:309.
24. Stohlman, S. A., S. Kyuwa, J. M. Polo, D. Brady, M. C. Lai, and C. Bergmann. 1993. Characterization of mouse hepatitis virus-specific cytotoxic T cells derived from the central nervous system of mice infected with the JHM strain. J. Virol. 67:7050.
25. Stohlman, S. A., and L. P. Weiner. 1981. Chronic central nervous system demyelination in mice after JHM virus infection. Neurology 31:38.
26. Fleming. J. O., J. J. Houtman, H. Alaca, H. C. Hinze, D. McKenzie, J. Aiken, T. Bleasdale, and S. Baker. 1994. Persistence of viral RNA in the central nervous system of mice inoculated with MHV-4. In Coronaviruses. H. Laude and J. F. Vautherot, eds. Plenum Press. New York, p. 327.
27. Stohlman, S. A., C. Bergmann, R. van der Veen, and D. Hinton. 1995. Mouse hepatitis virus nucleocapsid-specific cytotoxic T cells protect from lethal infection without eliminating virus from oligodendroglia. J. Virol. 69:684.
28. d-restricted cytotoxic T lymphocyte epitope in the mouse hepatitis virus nucleocapsid protein. J. Virol. 67:7041.
29. d-restricted cytotoxic T lymphocyte response to the mouse hepatitis virus nucleocapsid protein. J. Virol. 70:3252.
30. Stohlman, S. A., P. R. Braton, J. O. Fleming, L. P. Weiner, and M. C. Lai. 1982. Murine coronaviruses: isolation and characterization of two plaque morphology variants of the JHM neurotropic strain. J. Gen. Virol. 63:265.
31. Fleming, J. O., M. Trousdale, F. E. Zactarim, S. A. Stohlman, and L. P. Weiner. 1986. Pathogenicity of antigenic variants of murine coronavirus JHM selected with mAb. J. Virol 58:869.
32. d restricted and specific for the carboxy terminus. Virology 189:217.
33. MacDonald, H. R., N. Thiernesse, and J.-C. Cerottini. 1981. Inhibition of T cell-mediated cytolysis by monoclonal antibodies directed against Lyt-2: heterogeneity of inhibition at the clonal level. J. Immunol. 126:1671.
34. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156.
35. Harrington, C. J., A. Paez, T. Hunkapiller, V. Mannikko, T. Brabb, M. E. Ahearn, C. Beeson, and J. Goverman. 1998. Differential tolerance is induced in T cells recognizing distinct epitopes of myelin basic protein. Immunity 8:571.
36. Whitham, R. H., B. L. Kotzin, A. C. Buenafe, A. D. Weinberg, R. E. Jones, G. A Hashim, C. M. Hoy, A. A. Vandenbark, and H. Offner. 1993. Treatment of relapsing experimental autoimmune encephalomyelitis with T cell receptor peptides. J. Neurosci. Res. 35:115.
37. Louie, M. C., C. A. Nelson, and D. Y. Loh. 1989. Identification and characterization of new murine T cell β chain variable region (Vβ) genes. J. Exp. Med. 170:1987.
38. + T cells using an ELISPOT assay. J. Immunol. Methods 181:45.
39. Erlich, S., J. Fleming, S. Stohlman, and L. Weiner. 1987. Experimental neuropathology of remote infection with a JHM virus variant (DS). Arch. Neurol. 44:83.
40. d: sequence motif, quantitative binding and molecular modeling of the complex. J. Exp. Med. 176:1681.
41. Reddehase, M. J., and U. H. Koszinowski. 1991. Redistribution of critical major histocompatibility complex and T cell receptor-binding functions of residues in an antigenic sequence after biterminal substitution. Eur. J. Immunol. 21:1697.
42. Jameson, S. C., and M. J. Bevan. 1992. Dissection of major histocompatibility complex (MHC) and T cell receptor contact residues in a Kb-restricted ovalbumin peptide and an assessment of the predictive power of MHC-binding motifs. Eur. J. Immunol. 22:2663.
43. b epitope is focused on the center of the peptide. J. Immunol. 155:2841.
44. Chothia, C. D. R. Boswell, and A. M. Lesk. 1988. The outline structure of the T cell αβ receptor. EMBO J. 7:3745.
45. Rock, E. P., P. R. Sibbald, M. M. Davis, and Y. Chien. 1994. CDR3 length in antigen-specific immune receptors. J. Exp. Med. 179:323.
46. Ahmed, R., L. A. Morrison, and D. M Knipe. 1996. Persistence of viruses. In Fundamental Virology. B. N. Fields, D. M. Knipe, and P. M. Howleey, eds. Lippincott Raven, Philadelphia, p. 207.
47. Hawke, S., P. G. Stevenson, S. Freeman, and C. R. M. Bangham. 1998. Long-term persistence of activated cytotoxic T lymphocytes after viral infection of the central nervous system. J. Exp. Med. 187:1575.
48. Gavin, M. A., and M. J. Bevan. 1995. Increased peptide promiscuity provides a rationale for the lack of N regions in the neonatal T cell repertoire. Immunity 3:793.
49. McHeyzer-Williams, M. G., and M. M. Davis. 1995. Antigen-specific development of primary T cells in vivo. Science 268:106.
50. Musette, P., J.-F. Bureau, G. Gachelin, P. Kourilsky, and M. Brahic. 1995. T lymphocyte repertoire in Theiler's virus encephalomyelitis: the nonspecific infiltration of the central nervous system of infected SJL/J mice is associated with a selective local T cell expansion. Eur. J. Immunol. 25:1589.
51. Castro, R. F., G. D. Evans, A. Jaszewski, and S. Perlman. 1994. Coronavirus-induced demyelination occurs in the presence of virus-specific cytotoxic T cells. Virology 200:733.
52. Karin, N., F. Szafer, D. Mitchell, D. P. Gold, and L. Steinman. 1993. Selective and nonselective stages in homing of T lymphocytes to the central nervous system during experimental allergic encephalomyelitis. J. Immunol. 150:4116.
53. Evans, C. F., M. S. Horwitz, M. V. Hobbs, and M. B. A. Oldstone. 1996. Viral infection of transgenic mice expressing a viral protein in oligodendrocytes leads to chronic central nervous system autoimmune disease. J. Exp. Med. 184:2371.
54. Pewe, L., G. F. Wu, E. M. Barnett, R. F. Castro, and S. Perlman. 1996. Cytotoxic T cell-resistant variants are selected in a virus-induced demyelinating disease. Immunity 5:253.
55. Bergmann, C., E. Dimacali, S. Stohl, W. Wei, M. M. C. Lai, S. Tahara, and N. Marten. 1998. Variability of persisting MHV RNA sequences comprising immune and replication relevant domains. Virology 244:563.