In-vivo selection of an azole-resistant petite mutant of Candida glabrata

Journal of Medical Microbiology

Volumn 49, Issue 11, 2000, Pages 977-984

  Bouchara, J P ^a   Zouhair, R ^a   Le Boudouil, S ^a   Renier, G ^a   Filmon, R ^a   Chabasse, D ^a   Hallet, J N ^a   Defontaine, A ^a  

^a ANGERS UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; FLUCONAZOLE; KETOCONAZOLE; MITOCHONDRIAL DNA; TIOCONAZOLE;

ARTICLE; BONE MARROW TRANSPLANTATION; CANDIDA GLABRATA; CROSS RESISTANCE; DRUG SENSITIVITY; FECES CULTURE; FLOW CYTOMETRY; FLUORESCENCE; FUNGUS MUTANT; GENE AMPLIFICATION; IN VIVO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; SACCHAROMYCES CEREVISIAE; TRANSMISSION ELECTRON MICROSCOPY;

CANDIDA GLABRATA;

EID: 0033759999     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-49-11-977     Document Type: Article

References (42)

1. Fluconazole. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in superficial and systemic mycoses
2. Epidemiological shifts in opportunistic and nosocomial Candida infections: Mycological aspects
3. The changing face of candidemia: Emergence of non-Candida albicans species and antifungal resistance
4. Candida glabrata: Review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans
5. Fluconazole susceptibilities of Candida species and distribution of species recovered from blood cultures over a 5-year period
6. Occurrence of yeast bloodstream infections between 1987 and 1995 in five Dutch university hospitals
7. Mutation in cytochrome P450-dependent 14α-demethylase results in decreased affinity for azole antifungals
8. The mutation T315A in Candida albicans sterol 14-alpha-demethylase causes reduced enzyme activity and fluconazole resistance through reduced affinity
9. Molecular analysis of cyp51 from fluconazole-resistant Candida albicans strains
10. The presence of an R467K amino acid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 12-alpha-demethylase in Candida albicans
11. Amino acid substitutions in the cytochrome P-450 lanosterol 14α-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents
12. Characterization of an azole-resistant Candida glabrata isolate
13. Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters
14. Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus
15. Molecular biological characterization of an azole-resistant Candida glabrata isolate
16. 5.6-desaturation
17. Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals
18. Multidrug resistance in Candida albicans: Disruption of the BEN(r) gene
19. Cloning of Candida albicans genes conferring resistance to azole antifungal agents: Characterization of CDR2, a new multidrug ABC transporter gene
20. Induced expression of the Candida albicans multidrug resistance gene CDR1 in response to fluconazole and other antifungals
21. Fluconazole resistance associated with drug efflux and increased transcription of a drug transporter gene, PDH1, in Candida glabrata
22. In-vitro resistance to azoles associated with mitochondrial DNA deficiency in Candida glabrata
23. Contribution of various techniques of molecular analysis to strain identification of Candida glabrata
24. Identification of yeast isolates by using the polymerase chain reaction
25. Flow cytometry as a tool to discriminate respiratory-competent and respiratory-deficient yeast cells
26. Amplification and direct sequencing of fungal ribosomal RNA genes for phylogenetics
27. Induction of petite mutation with acriflavine and elevated temperature in Candida albicans
28. Fluconazole resistance in Candida glabrata
29. Fluconazole resistance due to energy-dependent drug efflux in Candida glabrata
30. Reproducibility and indices of discriminatory power of microbial typing methods
31. Comparison of Etest and National Committee for Clinical Laboratory Standards broth macrodilution method for antifungal susceptibility testing: Enhanced ability to detect amphotericin B-resistant Candida isolates
32. Comparison of Etest and National Committee for Clinical Laboratory Standards broth macrodilution method for azole antifungal susceptibility testing
33. In vitro susceptibilities of clinical yeast isolates to three antifungal agents determined by the micro-dilution method
34. DNA macrorestriction profiles and antifungal susceptibility of Candida (Torulopsis) glabrata
35. Use of rhodamine 123 to investigate alterations in mitochondrial activity in isolated mouse liver mitochondria
36. Localization of mitochondria in living cells with rhodamine 123
37. Ethidium bromide-induced mutation of yeast mitochondria: Complete transformation of cells into respiratory deficient non-chromosomal 'petites'
38. Isolation of a petite mutant from a histidine auxotroph of Candida albicans and its characterization
39. Microbial oxygenases and their potential application
40. Induction of petite mutation and inhibition of synthesis of respiratory enzymes in various yeasts
41. Azole susceptibility and hyphal formation in a cytochrome P-450-deficient mutant of Candida albicans
42. Azole resistance in Candida albicans