Induced expression of the Candida albicans multidrug resistance gene CDR1 in response to fluconazole and other antifungals

Yeast

Volumn 14, Issue 6, 1998, Pages 517-526

  Hernáez, María Luisa ^a   Gil, Concha ^a   Pla, Jesús ^a   Nombela, César ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Antifungal drugs; Candida albicans; Fluconazole; Multidrug resistance

Indexed keywords

AMPHOTERICIN B; ANTIFUNGAL AGENT; CAFFEINE; CANAVANINE; CILOFUNGIN; CYCLOHEXIMIDE; FLUCONAZOLE; FLUCYTOSINE; GREEN FLUORESCENT PROTEIN;

ANTIBIOTIC RESISTANCE; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; GENE EXPRESSION REGULATION; GENE FUSION; GENE INDUCTION; MULTIDRUG RESISTANCE; NONHUMAN; OPEN READING FRAME; PATHOGENICITY; PRIORITY JOURNAL; REPORTER GENE;

ANTIFUNGAL AGENTS; ARTIFICIAL GENE FUSION; ATP-BINDING CASSETTE TRANSPORTERS; CANDIDA ALBICANS; DRUG RESISTANCE, MICROBIAL; DRUG RESISTANCE, MULTIPLE; FLOW CYTOMETRY; FLUCONAZOLE; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GENES, FUNGAL; GREEN FLUORESCENT PROTEINS; LUMINESCENT PROTEINS; MEMBRANE TRANSPORT PROTEINS; MICROSCOPY, CONFOCAL; RECOMBINANT FUSION PROTEINS; TRANSFORMATION, GENETIC;

CANDIDA ALBICANS; FUNGI;

EID: 0032580438     PISSN: 0749503X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0061(19980430)14:6<517::AID-YEA250>3.0.CO;2-D     Document Type: Article

References (57)

1. Ausubel, F. M., Kingston, R. E., Brent, R., et al. (Eds) (1993). Current Protocols in Molecular Biology. Greene Publishing Associates and Wiley Interscience, New York.
2. Albertson, G. D., Niimi, M., Cannon, R. and Jenkinson, H. F. (1996). Multiple eflux mechanisms are involved in Candida albicans fluconazole resistance. Antimicrob. Agents Chemother. 40(12), 2835-2841.
3. Balzi, E. and Goffeau, A. (1991). Multiple or pleiotropic drug resistance in yeast. Biochim. Biophys. Acta 1073, 241-252.
4. Balzi, E. and Goffeau, A. (1994). Genetics and biochemistry of yeast multidrug resistance. Biochim. Biophys. Acta 1187, 152-162.
5. Balzi, E. and Goffeau, A. (1995). Yeast multidrug resistance: the PDR network. J Bioenerg. Biomembr. 27, 71-76.
6. Balzi, E., Wang, M., Leterme, S., Van Dyck, L. and Goffeau, A. (1994). PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1. J. Biol. Chem. 269, 2206-2214.
7. Becker, J. M., Henry, L. K., Jiang, W. and Koltin, Y. (1995). Reduced virulence of Candida albicans mutants affected in multidrug resistance. Infect. Immun. 63(11), 4515-4518.
8. Beggs, J. D. (1978). Transformation of yeast by a replicating hybrid plasmid. Nature 275(5676), 104-109.
9. Ben-Yaacov, R., Knoller, S., Caldwell, G. A., Becker, J. M. and Koltin, Y. (1994). Candida albicans gene encoding resistance to benomyl and methotrexate is a multidrug resistance gene. Antimicrob. Agents Chemother. 4, 648-652.
10. Bennett, J. E. (1996). Antimicrobial agents: antifungal agents. In Gilman, A. G., Rail, T. W., Sies, A. S. and Taylor, P. (Eds), Goodman and Gilman's the Pharmacological Basis of Therapeutics, 8th edn. Pergamon Press, Elmsford, NY, pp. 1165-1181.
11. Burns, N., Grimwade, B., Ross-Macdonald, P. B., et al. (1994). Large-scale analysis of gene expression, protein localization, and gene disruption in Saccharomyces cerevisiae. Genes Dev. 8(9), 1087-1105.
12. Chalfie, M., Tu, Y., Euskirchen, G., Ward, W. W. and Prasher, D. C. (1994). Green fluorescent protein as a marker for gene expression. Science 263(5148), 802-805.
13. Cormack, B. P., Bertram, G., Egerton, M., Gow, N. A. R., Falkow, S. and Brown, A. J. P. (1997). Yeast-enhanced green fluorescent protein (yEGFP): a reporter of gene expression in Candida albicans. Microbiology 143(2), 303-311.
14. Cormack, B. P., Valdivia, R. and Falkow, S. (1996). FACS-optimized mutants of the green fluorescent protein (GFP). Gene 173, 33-38.
15. Cubitt, A. B., Heim, R., Adams, S. R., Boyd, A. E., Gross, L. A. and Tsien, R. Y. (1995). Understanding, improving and using green fluorescent proteins. Trends Biochem. Sci. 20(11), 448-455.
16. de la Fuente, J. M., Alvarez, A., Nombela, C. and Sánchez, M. (1992). Flow cytometric analysis of Saccharomyces cerevisiae autolytic mutants and protoplasts. Yeast 8, 39-45.
17. Decottignies, A., Kolaczkowski, M., Balzi, E. and Goffeau, A. (1994). Solubilization and characterization of the overexpressed PDR5 multidrug resistance nucleotide triphosphatase of yeast. J. Biol. Chem. 269, 12,797-12,803.
18. Fling, M. E., Kopf, J., Tamarkin, A., German, J. A., Smith, H. A. and Koltin, Y. (1991). Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate. Mol. Gen. Genet. 227, 318-329.
19. Fonzi, W. A. and Irwin, M. Y. (1993). Isogenic strain construction and gene mapping in Candida albicans. Genetics 134, 717-728.
20. Fox, J. E. (1993). Fungal infection rates are increasing. ASM News 10, 515-518.
21. R gene. Antimicrob. Agents Chemother. 39, 422-426.
22. Hanahan, D. (1988). Techniques for transformation of E. coli. In Glover, D. M. (Ed.), DNA Cloning, 1st edn. IRE Press, Oxford, pp. 109-135.
23. Herreros, E., García-Sáez, M. I., Nombela, C. and Sánchez, M. (1992). A reorganized Candida albicans DNA sequence promoting homologous non-integrative genetic transformation. Mol Microbiol. 6, 3567-3574.
24. Higgins, C. F. (1995). The ABC of channel regulation. Cell 82, 693-696.
25. Higgins, D. G., Bleasby, A. J. and Fuchs, R. (1992). CLUSTAL V: improved software for multiple sequence alignment. Comput. Appl. Biosci. 2, 189-191.
26. Hill, J. E., Myers, A. M., Koerner, T. J. and Tzagoloff. A. (1986). Yeast/E. coli shuttle vectors with multiple unique restriction sites. Yeast 2, 163-167.
27. Hitchcock, C. A. (1993). Resistance of Candida albicans to azole antifungal agents. Biochem. Soc. Trans. 21(4), 1039-1047.
28. Hitchcock, C. A., Barrett-Bee, K. J. and Russell, N. J. (1987). The lipid composition and permeability to azole of an azole- and polyene-resistant mutant of Candida albicans. J. Med. Vet. Mycol. 25(1), 29-37.
29. Hitchcock, C. A., Barrett, B. K. and Russell, N. J. (1986). The lipid composition of azole-sensitive and azole-resistant strains of Candida albicans. J. Gen. Microbiol. 132, 2421-2431.
30. Hitchcock, C. A., Russell, N. J. and Barrett-Bee, K. J. (1987). Sterols in Candida albicans mutants resistant to polyene or azole antifungals, and of a double mutant C. albicans 6.4. Crit. Rev. Microbiol. 15, 111-115.
31. Jia, Z. P., McCullough, N., Wong, L. and Young, P. G. (1993). The amiloride resistance gene, carl, of Schizo-saccharomyces pombe. Mol. Gen. Genet. 241, 298-304.
32. Kawaguchi, Y., Honda, H., Taniguchi-Morimura, J. and Iwasaki, S. (1989). The codon CUG is read as serine in an asporogenic yeast Candida cylindracea. Nature 341, 164-166.
33. Leppert, G., McDevitt, R., Falco, S. C., Van Dyk, T. K., Ficke, M. B. and Golin, J. (1990). Cloning by gene amplification of two loci conferring multiple drug resistance in Saccharomyces. Genetics 125, 13-20.
34. Levy, S. B. (1992). Active efflux mechanisms for antimicrobial resistance. Antimicrob. Agents Chemother. 4, 695-703.
35. Marger, M. D. and Saier, M. H. J. (1993). A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport [see comments]. Trends Biochem. Sci. 18, 13-20.
36. Meyers, S., Schauer, W., Balzi, E., Wagner, M., Gofeau, A, and Golin, J. (1992). Interaction of the yeast pleiotropic drug resistance genes PDR1 and PDR5. Curr. Genet. 21(6), 431-436.
37. National Committee for Clinical Laboratory Standards (1992). Reference method for broth dilution antifungal susceptibility testing of yeast. Proposed standard M27-P. National Committee for Clinical Laboratory Standards, Villanova, Pa.
38. Navarro-García, F., Sánchez, M., Pla, J. and Nombela, C. (1995). Functional characterization of the MKCl gene of Candida albicans, which encodes a mitogen-activated protein kinase homolog related to cell integrity. Mol. Cell. Biol. 15(4), 2197-2206.
39. Negredo, A., Monteoliva, L., Gil, C., Pla, J. and Nombela, C. (1997). Cloning, analysis and one-step disruption of the ARG5,6 gene of Candida albicans. Microbiology 143(2), 297-302.
40. Ng, T. T. and Denning, D. W. (1993). Fluconazole resistance in Candida in patients with AIDS - a therapeutic approach. J Infect. 26(2), 117-125.
41. Odds, F. C. (1993). Resistance of yeasts to azolederivative antifungals. J. Antimicrob. Chemother. 31, 463-471.
42. Pla, J., Perez-Diaz, R. M., Navarro-García, F., Sánchez, M. and Nombela, C. (1995). Cloning of the Candida albicans HIS1 gene by direct complementation of a C. albicans histidine auxotroph using an improved double-ARS shuttle vector. Gene 165(1), 115-120.
43. Prasad, R., De Wergifosse, P., Goffeau, A. and Balzi, E. (1995). Molecular cloning and characterization of a novel gene of Candida albicans. CDR1, conferring multiple resistance to drugs and antifungals. Curr. Genet. 27(4), 320-329.
44. Rex, J. H., Rinaldi, M. G. and Pfaller, M. A. (1995). Resistance of Candida species to fluconazole. Antimicrob. Agents Chemother. 1, 1-8.
45. Sambrook, J., Fritsch, E. F. and Maniatis, T. (Eds) (1989). Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
46. Sanglard, D., Ischer, F., Monod, M. and Bille, J. (1996). Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors. Antimicrob. Agents Chemother. 10, 2300-2305.
47. Sanglard, D., Ischer, F., Monod, M. and Bille, J. (1997). Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 143, 405-416.
48. Sanglard, D., Kuchler, K., Ischer, F., Pagani, J. L., Monod, M. and Bille, J. (1995). Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. Antimicrob. Agents Chemother. 39(11), 2378-2386.
49. Santos, M. A. and Tuite, M. F. (1995). The CUG codon is decoded in vivo as serine and not leucine in Candida albicans. Nucl. Acids Res. 23, 1481-1486.
50. Sasnauskas, K., Jomantiene, R., Lebediene, E., Lebedys, J., Januska, A. and Janulaitis, A. (1992). Cloning and sequence analysis of a Candida maltosa gene which confers resistance to cycloheximide. Gene 116, 105-108.
51. Shaberg, D. R., Culver, D. H. and Gaynes, R. P. (1991). Major trends in the microbial etiology of nosocomial infection. Am. J. Med. 91(suppl. 3B), 72S-75S.
52. vanden Bossche, H. (1997). Mechanisms of antifungal resistance. Rev. Iberoam. Micol. 14, 44-49.
53. vanden Bossche, H., Marichal, P., Gorrens, J., Bellens, D., Moereels, H. and Janssen, P. A. (1990). Mutation in cytochrome P-450-dependent 14 alpha-demethylase results in decreased affinity for azole antifungals. Biochem. Soc. Trans. 18(1), 56-59.
54. vanden Bossche, H., Marichal, P. and Odds, F. C. (1994). Molecular mechanisms of drug resistance in fungi. Trends Microbiol. 2, 393-400.
55. vanden Bossche, H., Marichal, P., Odds, F. C., Le Jeune, L. and Coene, M. C. (1992). Characterization of an azole-resistant Candida glabrata isolate. Antimicrob. Agents Chemother. 12, 2602-2610.
56. White, T. C. (1997). The presence of an R467K amino acid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14α demethylase in Candida albicans. Antimicrob. Agents Chemother. 41(7), 1488-1494.
57. Yokogawa, T., Suzuki, T., Ueda, T., et al. (1992). Serine tRNA complementary to the nonuniversal serine codon CUG in Candida cylindracea: evolutionary implications. Proc. Natl. Acad. Sci. USA 89, 7408-7411.