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0026772206
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In vivo gene transfer with retroviral vector producer cells for the treatment of experimental brain tumors
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Use of recombinant adenovirus to transfer the herpes simplex thymidine kinase gene (HSVtk) to thoracic neoplasms: an effective in vitro drug sensitization system
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Treatment of experimental human mesothelioma using adenovirus transfer of the herpes simplex thymidine kinase gene
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Sensitization of human breast cancer cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P450 gene
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Gene-directed enzyme prodrug therapy: quantitative bystander cytotoxicity and DNA damage induced by CB1954 in cells expressing bacterial nitroreductase
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PID: 8840992, COI: 1:CAS:528:DyaK28XmsV2it7o%3D
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Marais R, Spooner RA, Light Y, et al.: Gene-directed enzyme prodrug therapy with a mustard prodrug/carboxypeptidase G2 combination. Cancer Res 1996, 56:4735–4742.
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0029913138
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PID: 8929915, COI: 1:CAS:528:DyaK28XhtVWms7g%3D
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0029996360
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Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins
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A comparison of the properties of different retroviral vectors containing the tyrosinase promoter to achieve transcriptionally targeted expression of the HSVtk or IL-2 genes
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PID: 7584096, COI: 1:CAS:528:DyaK2MXos1Ohsw%3D%3D
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PID: 8665496, COI: 1:CAS:528:DyaK28XjsFGkurk%3D
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Mechanism of ‘bystander effect’ killing in the herpes simplex thymidine kinase gene therapy model of cancer treatment
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0028075655
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Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component
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PID: 7954471, COI: 1:CAS:528:DyaK2MXisVSqt7c%3D
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COI: 1:CAS:528:DyaK2sXjsFCmtL8%3D, Report from the first study to demonstrate that intracranial administration of adenoviral-mediated prodrug gene therapy was likely to be relatively nontoxic to human patients. Both gross and microscopic pathologic findings nonhuman primates are also described
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Expression of costimulatory molecules: B7 and ICAM up-regulation after treatment with a suicide gene
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Ganciclovir-induced ablation of non-proliferating thyrocytes expressing herpes virus thymidine kinase occurs by p53-independent apoptosis
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Regional delivery of an adenovirus vector containing the Escheridia Coli cytosine deaminase gene to provide local activation of 5-fluorocytosine to suppress the growth of colon carcinoma metastatic to the liver
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PID: 9614575, COI: 1:CAS:528:DyaK1cXis1Cisrg%3D, This animal model paper demonstrates the potential efficacy of the only prodrug gene therapy pardigm other than HSVtk now at the clinical trial stage. This group is currently applying the phase I use of this adenoviral-mediated cytosine deaminase/5-FC system patients with metastatic colonic carcinoma to the liver
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Topf N, Worgall S, Hackett NR, Crystal RG: Regional "prodrug" gene therapy: intravenous administration of an adenoviral vector expressing the E. coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma. Gene Ther 1998, 5:507–513. This animal model paper demonstrates the potential efficacy of the only prodrug gene therapy pardigm other than HSVtk now at the clinical trial stage. This group is currently applying the phase I use of this adenoviral-mediated cytosine deaminase/5-FC system in patients with metastatic colonic carcinoma to the liver. DOI: 10.1038/sj.gt.3300611
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This phase I clinical trial report demonstrates that adenoviral-mediated prodrug gene therapy the pleural space is well tolerated, with minimal toxicity, and that gene transfer is possible at higher-density doses of vector. Although mesothelioma is an uncommon tumor, lessons learned from treatment of these patients may eventually be applicable to treatment of other human body cavity malignancies
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Treat J, Sterman DH, Litzky LA, et al.: Adenovirus-mediated herpes simplex thymidine kinase gene delivery in patients with localized malignancy: results of a phase I clinical trial in malignant mesothelioma. Human Gene Ther 1998, 9:1083–1092. This phase I clinical trial report demonstrates that adenoviral-mediated prodrug gene therapy in the pleural space is well tolerated, with minimal toxicity, and that gene transfer is possible at higher-density doses of vector. Although mesothelioma is an uncommon tumor, lessons learned from treatment of these patients may eventually be applicable to treatment of other human body cavity malignancies.
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