In vitro and in vivo antitumor effects of retrovirus-mediated herpes simplex thymidine kinase gene-transfer in human medulloblastoma

Gene Therapy

Volumn 5, Issue 1, 1998, Pages 113-120

  Rosolen, A ^a   Frascella, E ^a   Di Francesco, C ^a   Todesco, A ^a   Petrone, M ^a   Mehtali, M ^b   Zacchello, F ^a   Zanesco, L ^a   Scarpa, M ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b TRANSGENE S A   (France)

Author keywords

Bystander effect; Gene transfer; Medulloblastoma; Thymidine kinase

Indexed keywords

CONNEXIN 43; GANCICLOVIR; THYMIDINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; EXPRESSION VECTOR; GENE TRANSFER; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; MEDULLOBLASTOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS; SUICIDE GENE; VIRUS INFECTION;

ANIMALIA; HERPES; SIMPLEXVIRUS; UNIDENTIFIED RETROVIRUS;

EID: 0031983980     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300559     Document Type: Article

References (37)

1. Heideman RL et al. Tumors of the central nervous system. In. Pizzo PA, Poplack DG (eds). Principle and Practice of Pediatric Oncology. Lippincott-Raven: Philadelphia 1997, pp 633-697.
2. Borrelli E, Heyman R, Hsi M, Evans RM Targeting of an inducible toxic phenotype in animal cells. Proc Natl Acad Sci USA 1988; 85: 7572-7576.
3. Culver KW et al. In vivo gene transfer with retroviral-producer cells for treatment of experimental brain tumors. Science 1992; 256: 1550-1552.
4. Ezzeddine ZD et al. Selective killing of glioma cells in culture and in vivo by retrovirus gene transfer of the herpes simplex virus thymidine kinase gene. New Biol 1991; 3: 608-614.
5. Moolten FL. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res 1986; 46: 5276-5281.
6. Moolten FL, Wells JM. Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors. J Natl Cancer Inst 1990; 82: 297-300.
7. Ram Z et al. In situ retroviral gene transfer for the treatment of brain tumors in rats. Cancer Res 1992; 53: 83-88.
8. Field AK et al. 9-(2-Hydroxyl-1-hydroxymethyl, ethoxy)guanine: a selective inhibitor of herpes group virus replication. Proc Natl Acad Sci USA 1983; 80: 4139-4143.
9. Matthews T, Boehme R. Antiviral activity and mechanisms of action of ganciclovir. Rev Draft Dis 1988; 10: S490-S494.
10. Freeman SM et al. The 'Bystander effect': tumor regression when a fraction of tumor mass is genetically modified Cancer Res 1993; 53: 5274-5283.
11. Beck C et al. The thymidine kinase/ganciclovir-mediated 'suicide' effect is variable in different tumor cells. Hum Gene Ther 1995; 6: 1525-1530.
12. Chen CY et al. Effect of herpes simplex virus thymidine kinase expression levels on ganciclovir-mediated cytotoxicity and bystander effect. Hum Gene Ther 1995; 6: 1467-1476.
13. Samejima Y, Meruelo D. Bystander killing induces apoptosis and is inhibited by forskolin. Gene Therapy 1995; 2: 50-58.
14. Elshami AA et al. Gap junctions play a role in the 'bystander effect' of the herpes simplex virus thymidine kinase/ganciclovir system in vitro. Gene Therapy 1996; 3: 85-92.
15. Li Bi W, Parysek LM, Warnick R, Stambrook PJ. In vivo evidence that metabolic cooperation is responsible for the bystander effect observed with HSVik retroviral gene therapy. Hum Gene Ther 1993; 4: 725-731.
16. Fick J et al. The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro. Proc Natl Acad Sci USA 1995; 92: 11071-11075.
17. Loewenstein WR. Junctional intercellular communication the cell-to-cell membrane channel. Physiol Rev 1981; 61: 829-913.
18. Beyer EC, Paul DL, Goodenough DA. A protein from rat heart homologous to a gap junction protein from liver. J Cell Biol 1987; 105: 2621-2629.
19. Kumar NM, Gilula NB. The gap junction communication channels. Cell 1996; 84: 381-388.
20. Wu GY, Wu CH. Delivery systems for gene therapy. Biotherapy 1991; 3: 87-95.
21. Miller DG, Mohammed AA, Miller AD. Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection. Mol Cell Biol 1990; 10: 4239-4242.
22. Plautz G, Nabel EG, Nabel GJ. Selective elimination of recombinant genes in vivo with a suicide retroviral vector. New Biol 1991; 3: 709-715.
23. Fletcher C et al. Human pharmacokinetics of the antiviral drug DHPG. Clin Pharmacol Ther 1986; 40: 281-286.
24. Colombo BM et al. The 'bystander effect': association of U-87 cell death with ganciclovir-mediated apoptosis of nearby cells and lack of effect in athymic mice. Hum Gene Ther 1995; 6: 763-772.
25. Culver KW et al. Gene therapy for the treatment of malignant brain tumors with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system. Hum Gene Ther 1994; 5: 343-379.
26. Eck SL et al. Treatment of advanced CNS malignancies with the recombinant adenovirus H5.010RSVTK: a phase I trial. Hum Gene Ther 1996; 7: 1465-1482.
27. Raffel C et al. Gene therapy for the treatment of recurrent pediatric malignant astrocytomas with in vivo tumor transduction with the herpes simplex thymidine kinase gene/ganciclovir system. Hum Gene Ther 1994; 5: 863-890.
28. Kun LE et al. Stereotactic injection of herpes simplex thymidine kinase vector producer cells (PA317-G1Tk1SvNa.7) and intravenous ganciclovir for the treatment of progressive or recurrent primary supratentorial pediatric malignant brain tumors. Hum Gene Ther 1995; 6: 1231-1255.
29. Barba D, Hardin J, Sadelain M, Gage FH. Development of antitumor immunity following thymidine kinase-mediated killing of experimental brain tumors. Proc Natl Acad Sci USA 1994; 91: 4348-4352.
30. Markowitz D, Goff S, Bank A. A safe packaging line for gene transfer: separating viral genes on two different plasmids. J Virol 1988; 62: 1120-1124.
31. Markowitz D, Goff S, Bank A. Construction and use of a safe and efficient amphotropic packaging cell line. Virology 1988; 167: 400-404.
32. Twentyman PR, Fox NE, Rees JKH. Chemosensitivity testing of fresh leukemia cells using the MTT colorimetric assay. Br J Haematol 1989; 71: 19-24.
33. Miller D, Rosman G. Improved retroviral vectors for gene transfer and expression. Biotechniques 1989; 7: 980-988.
34. Spandidos DA, Harrison PR, Paul J. Replication and amplification of recombinant plasmid molecules as extra chromosomal elements in transformed mammalian cells. Exp Cell Res 1982; 141: 149-158.
35. Adra C, Boehr P, McBurney M Cloning and expression of the mouse pgk-1 gene and nucleotide sequence of its promoter. Gene 1987; 60: 65-74.
36. Morgenstern J, Land H. Advanced mammalian gene transfer: high titer retroviral vectors with multiple drug selection markers and a complementary helper free packaging cell line. Nucleic Acids Res 1990, 8: 3587-3596.
37. Graham FL, van der Erb AJ. A new technique for the assay of infectivity of human adenovirus type 5. J Gen Virol 1973; 52: 456-467.