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Bate CM. Pioneer neurones in an insect embryo. Nature. 260:1976;54-56.
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The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6
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Serafini T, Kennedy TE, Galko MJ, Mirzayan C, Jessell TM, Tessier-Lavigne M. The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell. 78:1994;409-424.
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Serafini, T.1
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Mirzayan, C.4
Jessell, T.M.5
Tessier-Lavigne, M.6
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The NTN2L gene encoding a novel human netrin maps to the autosomal dominant polycystic kidney disease region on chromosome 16p13.3
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Van Raay TJ, Foskett SM, Connors TD, Klinger KW, Landes GM, Burn TC. The NTN2L gene encoding a novel human netrin maps to the autosomal dominant polycystic kidney disease region on chromosome 16p13.3. Genomics. 41:1997;279-282.
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Genomics
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Van Raay, T.J.1
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Connors, T.D.3
Klinger, K.W.4
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Burn, T.C.6
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6
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0030220346
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Genetic analysis of netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons
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of special interest. Two Drosophila netrin genes are identified, their expression patterns analysed, and the results of loss- and gain-of-function assessed. Midline commissures are disrupted under both conditions, showing that the pattern of netrin expression is critical for netrin-based axon guidance.
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Mitchell KJ, Doyle JL, Serafini T, Goodman CS, Dickson BJ. Genetic analysis of netrin genes in Drosophila: netrins guide CNS commissural axons and peripheral motor axons. of special interest Neuron. 17:1996;203-215 Two Drosophila netrin genes are identified, their expression patterns analysed, and the results of loss- and gain-of-function assessed. Midline commissures are disrupted under both conditions, showing that the pattern of netrin expression is critical for netrin-based axon guidance.
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(1996)
Neuron
, vol.17
, pp. 203-215
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Mitchell, K.J.1
Doyle, J.L.2
Serafini, T.3
Goodman, C.S.4
Dickson, B.J.5
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7
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0030220353
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Guidance cues at the Drosophila CNS midline: Identification and characterization of two Drosophila netrin/UNC-6 homologs
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of special interest. This paper describes essentially the same strategy for the analysis of Drosophila netrin genes as [6]; as in the latter study, ectopic expression of either netrin throughout the CNS causes similar axon guidance defects to those seen in loss-of-function mutants.
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Harris R, Sabatelli LM, Seeger MA. Guidance cues at the Drosophila CNS midline: identification and characterization of two Drosophila netrin/UNC-6 homologs. of special interest Neuron. 17:1996;217-228 This paper describes essentially the same strategy for the analysis of Drosophila netrin genes as [6]; as in the latter study, ectopic expression of either netrin throughout the CNS causes similar axon guidance defects to those seen in loss-of-function mutants.
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(1996)
Neuron
, vol.17
, pp. 217-228
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Harris, R.1
Sabatelli, L.M.2
Seeger, M.A.3
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8
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0030582772
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Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system
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of outstanding interest. This paper describes the phenotype of netrin-1-deficient mice, highlighting the abnormal ventral commissures in the spinal cord and brain. The data provide strong evidence confirming the chemoattractive role of netrin-1 in guiding axons across the vertebrate midline, as well as the phylogenetic conservation of netrin function from nematodes to chordates.
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Serafini T, Colamarino SA, Leonardo ED, Wang H, Beddington R, Skarnes WC, Tessier-Lavigne M. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. of outstanding interest Cell. 87:1996;1001-1014 This paper describes the phenotype of netrin-1-deficient mice, highlighting the abnormal ventral commissures in the spinal cord and brain. The data provide strong evidence confirming the chemoattractive role of netrin-1 in guiding axons across the vertebrate midline, as well as the phylogenetic conservation of netrin function from nematodes to chordates.
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(1996)
Cell
, vol.87
, pp. 1001-1014
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Serafini, T.1
Colamarino, S.A.2
Leonardo, E.D.3
Wang, H.4
Beddington, R.5
Skarnes, W.C.6
Tessier-Lavigne, M.7
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9
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0030751752
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Axon tracts correlate with netrin-1a expression in the zebrafish embryo
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of special interest. A detailed study of netrin gene expression in zebrafish, with an analysis of the floating head mutant, providing further evidence that netrin attracts spinal commissural axons.
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Lauderdale JD, Davis NM, Kuwada JY. Axon tracts correlate with netrin-1a expression in the zebrafish embryo. of special interest Mol Cell Neurosci. 9:1997;293-313 A detailed study of netrin gene expression in zebrafish, with an analysis of the floating head mutant, providing further evidence that netrin attracts spinal commissural axons.
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(1997)
Mol Cell Neurosci
, vol.9
, pp. 293-313
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Lauderdale, J.D.1
Davis, N.M.2
Kuwada, J.Y.3
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10
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0030467075
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Guidance of circumferentially growing axons by netrin-dependent and -independent floor plate chemotropism in the vertebrate brain
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Shirasaki R, Mirzayan C, Tessier-Lavigne M, Murakami F. Guidance of circumferentially growing axons by netrin-dependent and -independent floor plate chemotropism in the vertebrate brain. Neuron. 17:1996;1079-1088.
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Neuron
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Shirasaki, R.1
Mirzayan, C.2
Tessier-Lavigne, M.3
Murakami, F.4
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11
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0030977861
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Directed growth of early cortical axons is influenced by a chemoattractant released from an intermediate target
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Richards LJ, Koester SE, Tuttle R, O'Leary DDM. Directed growth of early cortical axons is influenced by a chemoattractant released from an intermediate target. J Neurosci. 17:1997;2445-2458.
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J Neurosci
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Richards, L.J.1
Koester, S.E.2
Tuttle, R.3
O'Leary, D.D.M.4
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12
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0031441084
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A role for netrin-1 in the guidance of cortical efferents
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Métin C, Deléglise D, Serafini T, Kennedy TE, Tessier-Lavigne M. A role for netrin-1 in the guidance of cortical efferents. Development. 124:1997;5063-5074.
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Development
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Métin, C.1
Deléglise, D.2
Serafini, T.3
Kennedy, T.E.4
Tessier-Lavigne, M.5
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13
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0028061313
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Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord
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Kennedy TE, Serafini T, de la Torre JR, Tessier-Lavigne M. Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Cell. 78:1994;425-435.
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Kennedy, T.E.1
Serafini, T.2
De La Torre, J.R.3
Tessier-Lavigne, M.4
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14
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0030885519
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Netrin-1 and DCC mediate axon guidance locally at the optic disc: Loss of function leads to optic nerve hypoplasia
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of special interest. Further analysis of netrin-1-deficient mice shows a defect in guidance of retinal axons at the optic disc. In this case, netrin-1 appears to provide short-range guidance for axons.
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Deiner MS, Kennedy TE, Fazeli A, Serafini T, Tessier-Lavigne M, Sretavan DW. Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia. of special interest Neuron. 19:1997;575-589 Further analysis of netrin-1-deficient mice shows a defect in guidance of retinal axons at the optic disc. In this case, netrin-1 appears to provide short-range guidance for axons.
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(1997)
Neuron
, vol.19
, pp. 575-589
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Deiner, M.S.1
Kennedy, T.E.2
Fazeli, A.3
Serafini, T.4
Tessier-Lavigne, M.5
Sretavan, D.W.6
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15
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0030441213
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Netrin and netrin receptor expression in the embryonic mammalian nervous system suggests roles in retinal, striatal, nigral and cerebellar development
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Livesey FJ, Hunt SP. Netrin and netrin receptor expression in the embryonic mammalian nervous system suggests roles in retinal, striatal, nigral and cerebellar development. Mol Cell Neurosci. 8:1997;417-429.
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(1997)
Mol Cell Neurosci
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Livesey, F.J.1
Hunt, S.P.2
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16
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0343488508
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Expression and regulation of a netrin homolog in the zebrafish embryo
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Strähle U, Fischer N, Blader P. Expression and regulation of a netrin homolog in the zebrafish embryo. Mech Dev. 62:1997;147-160.
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(1997)
Mech Dev
, vol.62
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Strähle, U.1
Fischer, N.2
Blader, P.3
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17
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0345404151
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Turning of retinal growth cones in a netrin-1 gradient mediated by the netrin receptor DCC
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of special interest. A clear demonstration that netrin-1 alone is sufficient to evoke axon turning in vitro, through a DCC-mediated response. The results also support those of Deiner et al. [14] in showing a role for netrin-1 in retinal axon guidance.
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De la Torre JR, Höpker VH, Ming G-I, Poo M-m, Tessier-Lavigne M, Hemmati-Brivanlou A, Holt CE. Turning of retinal growth cones in a netrin-1 gradient mediated by the netrin receptor DCC. of special interest Neuron. 19:1997;1211-1224 A clear demonstration that netrin-1 alone is sufficient to evoke axon turning in vitro, through a DCC-mediated response. The results also support those of Deiner et al. [14] in showing a role for netrin-1 in retinal axon guidance.
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(1997)
Neuron
, vol.19
, pp. 1211-1224
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De La Torre, J.R.1
Höpker, V.H.2
Ming G-I3
Poo M-M4
Tessier-Lavigne, M.5
Hemmati-Brivanlou, A.6
Holt, C.E.7
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18
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0030592522
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Deleted in Colorectal Cancer (DCC) encodes a netrin receptor
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of outstanding interest. The identification of DCC as a netrin receptor by homology screening. The paper reports a combination of in vitro binding studies, analysis of protein expression in vivo, and results of functional perturbation using neutralizing antibody.
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Keino-Masu K, Masu M, Hinck L, Leonardo ED, Chan SSY, Culotti JG, Tessier-Lavigne M. Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. of outstanding interest Cell. 87:1996;175-185 The identification of DCC as a netrin receptor by homology screening. The paper reports a combination of in vitro binding studies, analysis of protein expression in vivo, and results of functional perturbation using neutralizing antibody.
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(1996)
Cell
, vol.87
, pp. 175-185
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Keino-Masu, K.1
Masu, M.2
Hinck, L.3
Leonardo, E.D.4
Chan, S.S.Y.5
Culotti, J.G.6
Tessier-Lavigne, M.7
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19
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0030995125
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Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene
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of outstanding interest. Reports the DCC knockout phenotype, showing strong similarity to the netrin-1 knockout phenotype.
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Fazeli A, Dickinson SL, Hermiston ML, Tighe RV, Steen RG, Small CG, Stoeckli ET, Keino-Masu K, Masu M, Rayburn H, et al. Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. of outstanding interest Nature. 386:1997;796-804 Reports the DCC knockout phenotype, showing strong similarity to the netrin-1 knockout phenotype.
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(1997)
Nature
, vol.386
, pp. 796-804
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Fazeli, A.1
Dickinson, S.L.2
Hermiston, M.L.3
Tighe, R.V.4
Steen, R.G.5
Small, C.G.6
Stoeckli, E.T.7
Keino-Masu, K.8
Masu, M.9
Rayburn, H.10
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20
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0030592577
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Frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance
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of outstanding interest. Identification and functional analysis of a Drosophila netrin receptor with homology to DCC. The midline phenotype of the frazzled null mutant is identical to that of netrin loss-of-function and can be rescued by pan-neural expression of frazzled.
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Kolodziej PA, Timpe LC, Mitchell KJ, Fried SR, Goodman CS, Jan LY, Jan YN. frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance. of outstanding interest Cell. 87:1996;197-204 Identification and functional analysis of a Drosophila netrin receptor with homology to DCC. The midline phenotype of the frazzled null mutant is identical to that of netrin loss-of-function and can be rescued by pan-neural expression of frazzled.
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(1996)
Cell
, vol.87
, pp. 197-204
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Kolodziej, P.A.1
Timpe, L.C.2
Mitchell, K.J.3
Fried, S.R.4
Goodman, C.S.5
Jan, L.Y.6
Jan, Y.N.7
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21
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0030592485
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UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues
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of outstanding interest. Reports the positional cloning of unc-40, revealing homology with vertebrate DCC and neogenin. The paper also suggests that UNC-40 and UNC-5 are required as co-receptors to orient migrating cells away from a source of netrin/UNC-6.
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Chan SSY, Zheng H, Su MW, Wilk R, Killeen MT, Hedgecock EM, Culotti JG. UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues. of outstanding interest Cell. 87:1996;187-195 Reports the positional cloning of unc-40, revealing homology with vertebrate DCC and neogenin. The paper also suggests that UNC-40 and UNC-5 are required as co-receptors to orient migrating cells away from a source of netrin/UNC-6.
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(1996)
Cell
, vol.87
, pp. 187-195
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Chan, S.S.Y.1
Zheng, H.2
Su, M.W.3
Wilk, R.4
Killeen, M.T.5
Hedgecock, E.M.6
Culotti, J.G.7
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22
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Axon guidance mechanisms in Caenorhabditis elegans
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Culotti JG. Axon guidance mechanisms in Caenorhabditis elegans. Curr Opin Genet Dev. 4:1994;587-595.
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Culotti, J.G.1
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23
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Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans
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Wadsworth WG, Bhatt H, Hedgecock EM. Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans. Neuron. 16:1996;35-46.
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Neuron
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Wadsworth, W.G.1
Bhatt, H.2
Hedgecock, E.M.3
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24
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The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons
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Colamarino SA, Tessier-Lavigne M. The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons. Cell. 81:1995;621-629.
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Cell
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Colamarino, S.A.1
Tessier-Lavigne, M.2
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25
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Motor axon subpopulations respond differentially to the chemorepellents netrin-1 and semaphorin D
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Varela-Echavarria A, Tucker A, Püschel AW, Guthrie S. Motor axon subpopulations respond differentially to the chemorepellents netrin-1 and semaphorin D. Neuron. 18:1997;193-207.
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Neuron
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Varela-Echavarria, A.1
Tucker, A.2
Püschel, A.W.3
Guthrie, S.4
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26
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0031443998
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CAMP-dependent growth cone guidance by netrin-1
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of special interest. Good in vitro evidence that netrin can both attract and repel the same population of axons, depending on cAMP levels within the growth core. The two responses may therefore share similar signal transduction mechanisms.
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Ming G-I, Song H-j, Berninger B, Holt CE, Tessier-Lavigne M, Poo M-m. cAMP-dependent growth cone guidance by netrin-1. of special interest Neuron. 19:1997;1225-1235 Good in vitro evidence that netrin can both attract and repel the same population of axons, depending on cAMP levels within the growth core. The two responses may therefore share similar signal transduction mechanisms.
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(1997)
Neuron
, vol.19
, pp. 1225-1235
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Ming G-I1
Song H-J2
Berninger, B.3
Holt, C.E.4
Tessier-Lavigne, M.5
Poo M-M6
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27
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0030888324
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Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors
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of special interest. Reports the cloning of two rat homologs of UNC-5, a candidate receptor for netrin-based repulsive responses in C. elegans (see [22]). The vertebrate homologs define a new subfamily of the immunoglobulin superfamily, and are expressed in a variety of differentiating neurons in the developing brain and spinal cord. They are also shown to bind netrin-1 with high affinity, consistent with a role as netrin receptors with the potential to mediate repulsive responses.
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Leonardo ED, Hinck L, Masu M, Keino-Masu K, Ackerman SL, Tessier-Lavigne M. Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. of special interest Nature. 386:1997;833-838 Reports the cloning of two rat homologs of UNC-5, a candidate receptor for netrin-based repulsive responses in C. elegans (see [22]). The vertebrate homologs define a new subfamily of the immunoglobulin superfamily, and are expressed in a variety of differentiating neurons in the developing brain and spinal cord. They are also shown to bind netrin-1 with high affinity, consistent with a role as netrin receptors with the potential to mediate repulsive responses.
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(1997)
Nature
, vol.386
, pp. 833-838
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Leonardo, E.D.1
Hinck, L.2
Masu, M.3
Keino-Masu, K.4
Ackerman, S.L.5
Tessier-Lavigne, M.6
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28
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The Semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules
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Kolodkin AL, Matthes DJ, Goodman CS. The Semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules. Cell. 75:1993;1389-1399.
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Cell
, vol.75
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Kolodkin, A.L.1
Matthes, D.J.2
Goodman, C.S.3
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29
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0027373701
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Collapsin: A protein in brain that induces the collapse and paralysis of neuronal growth cones
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Luo Y, Raible D, Raper JA. Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones. Cell. 75:1993;217-227.
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(1993)
Cell
, vol.75
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Luo, Y.1
Raible, D.2
Raper, J.A.3
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30
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0029008344
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A family of molecules related to collapsin in the embryonic chick nervous system
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Luo Y, Shepherd I, Li M, Renzi MJ, Chang S, Raper JA. A family of molecules related to collapsin in the embryonic chick nervous system. Neuron. 14:1995;1131-1140.
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(1995)
Neuron
, vol.14
, pp. 1131-1140
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Luo, Y.1
Shepherd, I.2
Li, M.3
Renzi, M.J.4
Chang, S.5
Raper, J.A.6
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31
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Semaphorins: Mediators of repulsive growth cone guidance
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Kolodkin A. Semaphorins: mediators of repulsive growth cone guidance. Trends Cell Biol. 6:1996;15-22.
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Trends Cell Biol
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Kolodkin, A.1
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Fasciclin IV: Sequence, expression, and function during growth cone guidance in the grasshopper embryo
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Kolodkin AL, Matthes DJ, O'Connor TP, Patel NH, Admon A, Bentley D, Goodman CS. Fasciclin IV: sequence, expression, and function during growth cone guidance in the grasshopper embryo. Neuron. 9:1992;831-845.
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(1992)
Neuron
, vol.9
, pp. 831-845
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Kolodkin, A.L.1
Matthes, D.J.2
O'Connor, T.P.3
Patel, N.H.4
Admon, A.5
Bentley, D.6
Goodman, C.S.7
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33
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0030856306
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Transmembrane grasshopper semaphorin I promotes axon outgrowth in vivo
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of special interest. This paper shows that transmembrane semaphorins may have bifunctional properties in axon guidance, providing permissive/attractive cues for some axons alongside repulsive cues for others.
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Wong JTW, Yu WTC, O'Connor TP. Transmembrane grasshopper semaphorin I promotes axon outgrowth in vivo. of special interest Development. 124:1997;3597-3607 This paper shows that transmembrane semaphorins may have bifunctional properties in axon guidance, providing permissive/attractive cues for some axons alongside repulsive cues for others.
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(1997)
Development
, vol.124
, pp. 3597-3607
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Wong, J.T.W.1
Yu, W.T.C.2
O'Connor, T.P.3
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Localized collapsing cues can steer growth cones without inducing their full collapse
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Fan J, Raper JA. Localized collapsing cues can steer growth cones without inducing their full collapse. Neuron. 14:1995;263-274.
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(1995)
Neuron
, vol.14
, pp. 263-274
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Fan, J.1
Raper, J.A.2
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35
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0029037182
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Semaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cord
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Messersmith EK, Leonardo ED, Shatz CJ, Tessier-Lavigne M, Goodman CS, Kolodkin AL. Semaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cord. Neuron. 14:1995;949-959.
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(1995)
Neuron
, vol.14
, pp. 949-959
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Messersmith, E.K.1
Leonardo, E.D.2
Shatz, C.J.3
Tessier-Lavigne, M.4
Goodman, C.S.5
Kolodkin, A.L.6
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36
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0030152961
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The sensory innervation of the mouse spinal cord may be patterned by differential expression of and differential responsiveness to semaphorins
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Püschel AW, Adams RH, Betz H. The sensory innervation of the mouse spinal cord may be patterned by differential expression of and differential responsiveness to semaphorins. Mol Cell Neurosci. 7:1996;419-431.
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(1996)
Mol Cell Neurosci
, vol.7
, pp. 419-431
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Püschel, A.W.1
Adams, R.H.2
Betz, H.3
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37
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0030023741
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The distribution of collapsin-1 mRNA in the developing chick nervous system
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Shepherd I, Luo Y, Raper JA, Chang S. The distribution of collapsin-1 mRNA in the developing chick nervous system. Dev Biol. 173:1996;185-199.
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(1996)
Dev Biol
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Shepherd, I.1
Luo, Y.2
Raper, J.A.3
Chang, S.4
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38
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0030936559
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A sensory axon repellent secreted from ventral spinal cord explants is neutralized by antibodies raised against collapsin-1
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of special interest. This study shows that antibodies raised against chick collapsin-1/Sema III neutralize the chemorepulsive activity of chick ventral spinal cord explants for sensory axons, supporting the possibility that repulsion by collapsin-1/Sema III may guide sensory afferent targeting in the spinal cord in vivo.
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Shepherd IT, Luo Y, Lefcort F, Reichardt LF, Raper JA. A sensory axon repellent secreted from ventral spinal cord explants is neutralized by antibodies raised against collapsin-1. of special interest Development. 124:1997;1377-1385 This study shows that antibodies raised against chick collapsin-1/Sema III neutralize the chemorepulsive activity of chick ventral spinal cord explants for sensory axons, supporting the possibility that repulsion by collapsin-1/Sema III may guide sensory afferent targeting in the spinal cord in vivo.
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(1997)
Development
, vol.124
, pp. 1377-1385
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Shepherd, I.T.1
Luo, Y.2
Lefcort, F.3
Reichardt, L.F.4
Raper, J.A.5
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39
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0027167702
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Ventral spinal cord inhibition of neurite outgrowth from embryonic rat dorsal root ganglia
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Fitzgerald M, Kwiat GC, Middleton J, Pini A. Ventral spinal cord inhibition of neurite outgrowth from embryonic rat dorsal root ganglia. Development. 117:1993;1377-1384.
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Development
, vol.117
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Fitzgerald, M.1
Kwiat, G.C.2
Middleton, J.3
Pini, A.4
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40
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0029858256
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Semaphorin III is needed for normal patterning and growth of nerves, bones and heart
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of special interest. Reports the phenotype of the sema III knockout mouse. The main abnormality in the nervous system is the extension of CGRP-positive sensory afferents beyond their normal territory in the spinal cord. This contrasts with the normal spinal cord phenotype described in [41].
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Behar O, Golden JA, Mashimo H, Schoen FJ, Fishman MC. Semaphorin III is needed for normal patterning and growth of nerves, bones and heart. of special interest Nature. 383:1996;525-528 Reports the phenotype of the sema III knockout mouse. The main abnormality in the nervous system is the extension of CGRP-positive sensory afferents beyond their normal territory in the spinal cord. This contrasts with the normal spinal cord phenotype described in [41].
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(1996)
Nature
, vol.383
, pp. 525-528
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Behar, O.1
Golden, J.A.2
Mashimo, H.3
Schoen, F.J.4
Fishman, M.C.5
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41
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0030987542
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Disruption of Semaphorin III/D gene causes severe abnormality in peripheral nerve projection
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of special interest. Reports the phenotype of another sema III knockout mouse. In contrast to [40], no abnormalities of sensory afferent targeting in the spinal cord are described, but abnormal axon branches are seen to sprout laterally from the DRGs, and aberrant peripheral axon trajectories are seen in the branchial arches, periocular region and limb buds.
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Taniguchi M, Yuasa S, Fujisawa H, Naruse I, Saga S, Mishina M, Yagi T. Disruption of Semaphorin III/D gene causes severe abnormality in peripheral nerve projection. of special interest Neuron. 19:1997;519-530 Reports the phenotype of another sema III knockout mouse. In contrast to [40], no abnormalities of sensory afferent targeting in the spinal cord are described, but abnormal axon branches are seen to sprout laterally from the DRGs, and aberrant peripheral axon trajectories are seen in the branchial arches, periocular region and limb buds.
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(1997)
Neuron
, vol.19
, pp. 519-530
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-
Taniguchi, M.1
Yuasa, S.2
Fujisawa, H.3
Naruse, I.4
Saga, S.5
Mishina, M.6
Yagi, T.7
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42
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0030847193
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Neuropilin is a receptor for the axonal chemorepellent semaphorin III
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of special interest. Together with [43], this paper reports the expression cloning and binding properties of neuropilin as a repulsion receptor for Sema III. Neuropilin is shown to be expressed on Sema III-responsive axons, and neutralizing antineuropilin antibodies block Sema III-mediated repulsive responses in vitro.
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He Z, Tessier-Lavigne M. Neuropilin is a receptor for the axonal chemorepellent semaphorin III. of special interest Cell. 90:1997;739-751 Together with [43], this paper reports the expression cloning and binding properties of neuropilin as a repulsion receptor for Sema III. Neuropilin is shown to be expressed on Sema III-responsive axons, and neutralizing antineuropilin antibodies block Sema III-mediated repulsive responses in vitro.
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(1997)
Cell
, vol.90
, pp. 739-751
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He, Z.1
Tessier-Lavigne, M.2
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43
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0030829388
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Neuropilin is a semaphorin III receptor
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of special interest. Together with [42], this paper describes the identification and characterization of neuropilin as a Sema III receptor. It also describes the cloning of neuropilin-2 (see also [45]).
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Kolodkin AL, Levengood DV, Rowe EG, Tai Y-T, Giger RJ, Ginty DD. Neuropilin is a semaphorin III receptor. of special interest Cell. 90:1997;753-762 Together with [42], this paper describes the identification and characterization of neuropilin as a Sema III receptor. It also describes the cloning of neuropilin-2 (see also [45]).
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(1997)
Cell
, vol.90
, pp. 753-762
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-
Kolodkin, A.L.1
Levengood, D.V.2
Rowe, E.G.3
Tai Y-T4
Giger, R.J.5
Ginty, D.D.6
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44
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0029093153
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Expression of a cell adhesion molecule, neuropilin, in the developing chick nervous system
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Takagi S, Kasuya Y, Shimizu M, Matsuura T, Tsuboi M, Kawakami A, Fujisawa H. Expression of a cell adhesion molecule, neuropilin, in the developing chick nervous system. Dev Biol. 170:1995;207-222.
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(1995)
Dev Biol
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Takagi, S.1
Kasuya, Y.2
Shimizu, M.3
Matsuura, T.4
Tsuboi, M.5
Kawakami, A.6
Fujisawa, H.7
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45
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0342872023
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Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III
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of special interest. Identification of a second member of the neuropilin family. The study reveals differential affinities of individual semaphorins for neuropilin-1 and -2, as well as largely nonoverlapping expression patterns for the two neuropilins in the developing nervous system. See also [43]
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Chen H, Chédotal A, He Z, Goodman CS, Tessier-Lavigne M. Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. of special interest Neuron. 19:1997;547-559 Identification of a second member of the neuropilin family. The study reveals differential affinities of individual semaphorins for neuropilin-1 and -2, as well as largely nonoverlapping expression patterns for the two neuropilins in the developing nervous system. See also [43].
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(1997)
Neuron
, vol.19
, pp. 547-559
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Chen, H.1
Chédotal, A.2
He, Z.3
Goodman, C.S.4
Tessier-Lavigne, M.5
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46
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0030930310
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Secreted chick semaphorins bind recombinant neuropilin with similar affinities but bind different subsets of neurons in situ
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of special interest. Reports the use of AP-tagged collapsins/semaphorins to assess the distribution of their receptors during neural development. Individual members of the family show distinct anatomical patterns of binding in tissue sections, and the semaphorin domain is shown to determine binding specificity.
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Feiner L, Koppel AM, Kobayashi H, Raper JA. Secreted chick semaphorins bind recombinant neuropilin with similar affinities but bind different subsets of neurons in situ. of special interest Neuron. 19:1997;539-545 Reports the use of AP-tagged collapsins/semaphorins to assess the distribution of their receptors during neural development. Individual members of the family show distinct anatomical patterns of binding in tissue sections, and the semaphorin domain is shown to determine binding specificity.
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(1997)
Neuron
, vol.19
, pp. 539-545
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-
Feiner, L.1
Koppel, A.M.2
Kobayashi, H.3
Raper, J.A.4
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47
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0030886550
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A 70 amino acid region within the semaphorin domain activates specific cellular response of semaphorin family members
-
of special interest. Domain swapping experiments show that a small region of the semaphorin domain confers specificity of binding and biological activity on individual members of the collapsin/semaphorin family.
-
Koppel A, Feiner L, Kobayashi H, Raper JA. A 70 amino acid region within the semaphorin domain activates specific cellular response of semaphorin family members. of special interest Neuron. 19:1997;531-537 Domain swapping experiments show that a small region of the semaphorin domain confers specificity of binding and biological activity on individual members of the collapsin/semaphorin family.
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(1997)
Neuron
, vol.19
, pp. 531-537
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Koppel, A.1
Feiner, L.2
Kobayashi, H.3
Raper, J.A.4
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48
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0030778454
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Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice
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of special interest. Reports the phenotype of neuropilin knockout mice, showing substantial similarity to the sema III knockout phenotype described by Taniguchi et al. [41].
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Kitsukawa T, Shimizu M, Sanbo M, Hirata T, Taniguchi M, Bekku Y, Yagi T, Fujisawa H. Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice. of special interest Neuron. 19:1997;995-1005 Reports the phenotype of neuropilin knockout mice, showing substantial similarity to the sema III knockout phenotype described by Taniguchi et al. [41].
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(1997)
Neuron
, vol.19
, pp. 995-1005
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Kitsukawa, T.1
Shimizu, M.2
Sanbo, M.3
Hirata, T.4
Taniguchi, M.5
Bekku, Y.6
Yagi, T.7
Fujisawa, H.8
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49
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0030929986
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The Eph receptor family: Axonal guidance by contact repulsion
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Orioli D, Klein R. The Eph receptor family: axonal guidance by contact repulsion. Trends Genet. 13:1997;354-359.
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Trends Genet
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, pp. 354-359
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Orioli, D.1
Klein, R.2
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50
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0030561320
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Spinal nerve segmentation in higher vertebrates: Axon guidance by repulsion and attraction
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Keynes RJ, Johnson AR, Pini A, Tannahill D, Cook GMW. Spinal nerve segmentation in higher vertebrates: axon guidance by repulsion and attraction. Semin Neurosci. 8:1996;339-345.
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(1996)
Semin Neurosci
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Keynes, R.J.1
Johnson, A.R.2
Pini, A.3
Tannahill, D.4
Cook, G.M.W.5
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51
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0025303953
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Isolation from chick somites of a glycoprotein fraction that causes collapse of dorsal root ganglion growth cones
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Davies JA, Cook GMW, Stern CD, Keynes RJ. Isolation from chick somites of a glycoprotein fraction that causes collapse of dorsal root ganglion growth cones. Neuron. 4:1990;11-20.
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Neuron
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Davies, J.A.1
Cook, G.M.W.2
Stern, C.D.3
Keynes, R.J.4
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52
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0028973307
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The guidance molecule semaphorin III is expressed in regions of spinal cord and periphery avoided by growing sensory axons
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Wright DE, White FA, Gerfen RW, Silos-Santiago I, Snider WD. The guidance molecule semaphorin III is expressed in regions of spinal cord and periphery avoided by growing sensory axons. J Comp Neurol. 361:1995;321-333.
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J Comp Neurol
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Wright, D.E.1
White, F.A.2
Gerfen, R.W.3
Silos-Santiago, I.4
Snider, W.D.5
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53
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0029938472
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A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis
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Adams RH, Betz H, Puschel AW. A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis. Mech Dev. 57:1996;33-45.
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Mech Dev
, vol.57
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Adams, R.H.1
Betz, H.2
Puschel, A.W.3
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54
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0029832383
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Inhibition of motor axon growth by T-cadherin substrata
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Fredette BJ, Miller J, Ranscht B. Inhibition of motor axon growth by T-cadherin substrata. Development. 122:1996;3163-3171.
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(1996)
Development
, vol.122
, pp. 3163-3171
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Fredette, B.J.1
Miller, J.2
Ranscht, B.3
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55
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0029076219
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Versican is selectively expressed in embryonic tissues that act as barriers to neural crest cell migration and axon outgrowth
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Landolt RM, Vaughan L, Winterhalter KH, Zimmerman DR. Versican is selectively expressed in embryonic tissues that act as barriers to neural crest cell migration and axon outgrowth. Development. 121:1995;2303-2312.
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(1995)
Development
, vol.121
, pp. 2303-2312
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Landolt, R.M.1
Vaughan, L.2
Winterhalter, K.H.3
Zimmerman, D.R.4
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56
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0030601973
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Expression pattern of collagen IX and potential role in the segmentation of the peripheral nervous system
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Ring C, Hassell J, Halfter W. Expression pattern of collagen IX and potential role in the segmentation of the peripheral nervous system. Dev Biol. 180:1996;41-53.
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(1996)
Dev Biol
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Ring, C.1
Hassell, J.2
Halfter, W.3
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57
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0030890656
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Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowth
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of outstanding interest. Ephrins are expressed in the posterior half-somite, and repel motor axons and migrating neural crest cells in a variety of in vitro assays. Together with [58], this study identifies ephrins as candidates for mediating peripheral nerve segmentation in higher vertebrates.
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Wang HU, Anderson DJ. Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowth. of outstanding interest Neuron. 18:1997;383-396 Ephrins are expressed in the posterior half-somite, and repel motor axons and migrating neural crest cells in a variety of in vitro assays. Together with [58], this study identifies ephrins as candidates for mediating peripheral nerve segmentation in higher vertebrates.
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(1997)
Neuron
, vol.18
, pp. 383-396
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Wang, H.U.1
Anderson, D.J.2
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58
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0031214537
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Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration
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of outstanding interest. This study describes the restriction of ephrin expression in the somites to the posterior half-sclerotomes. Cognate Eph receptors are expressed by migrating neural crest cells, and crest migration patterns are perturbed in explants of chick embryo trunks treated with soluble ephrin. Together with [57], this study identifies ephrins as candidates for mediating peripheral nerve segmentation in higher vertebrates.
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Krull CE, Lansford R, Gale NW, Collazo A, Marcelle C, Yancopoulos GD, Fraser SE, Bronner-Fraser M. Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration. of outstanding interest Curr Biol. 7:1997;571-580 This study describes the restriction of ephrin expression in the somites to the posterior half-sclerotomes. Cognate Eph receptors are expressed by migrating neural crest cells, and crest migration patterns are perturbed in explants of chick embryo trunks treated with soluble ephrin. Together with [57], this study identifies ephrins as candidates for mediating peripheral nerve segmentation in higher vertebrates.
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(1997)
Curr Biol
, vol.7
, pp. 571-580
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Krull, C.E.1
Lansford, R.2
Gale, N.W.3
Collazo, A.4
Marcelle, C.5
Yancopoulos, G.D.6
Fraser, S.E.7
Bronner-Fraser, M.8
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59
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0030042190
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The receptor tyrosine kinase, Cek8, is transiently expressed on subtypes of motoneurons in the spinal cord during development
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Ohta K, Nakamura M, Hirokawa K, Tanaka S, Iwama A, Suda T, Ando M, Tanaka H. The receptor tyrosine kinase, Cek8, is transiently expressed on subtypes of motoneurons in the spinal cord during development. Mech Dev. 54:1996;59-69.
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(1996)
Mech Dev
, vol.54
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Ohta, K.1
Nakamura, M.2
Hirokawa, K.3
Tanaka, S.4
Iwama, A.5
Suda, T.6
Ando, M.7
Tanaka, H.8
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60
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0030743413
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The inhibitory effect on neurite outgrowth of motoneurons exerted by the ligands ELF-1 and RAGS
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Ohta K, Iwamasa I, Drescher U, Terasaki H, Tanaka H. The inhibitory effect on neurite outgrowth of motoneurons exerted by the ligands ELF-1 and RAGS. Mech Dev. 64:1997;127-135.
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Mech Dev
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Ohta, K.1
Iwamasa, I.2
Drescher, U.3
Terasaki, H.4
Tanaka, H.5
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61
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0029986626
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Expression of the Tyro4/Mek4/Cek4 gene specifically marks a subset of embryonic motor neurons and their muscle targets
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Kilpatrick TJ, Brown A, Lai C, Gassmann M, Goulding M, Lemke G. Expression of the Tyro4/Mek4/Cek4 gene specifically marks a subset of embryonic motor neurons and their muscle targets. Mol Cell Neurosci. 7:1996;62-74.
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Mol Cell Neurosci
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, pp. 62-74
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Kilpatrick, T.J.1
Brown, A.2
Lai, C.3
Gassmann, M.4
Goulding, M.5
Lemke, G.6
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62
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0030221910
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The Eph kinase ligand AL-1 is expressed by rostral muscles and inhibits outgrowth from caudal neurons
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Donoghue MJ, Lewis RM, Merlie JP, Sanes JR. The Eph kinase ligand AL-1 is expressed by rostral muscles and inhibits outgrowth from caudal neurons. Mol Cell Neurosci. 8:1996;185-198.
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Mol Cell Neurosci
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, pp. 185-198
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Donoghue, M.J.1
Lewis, R.M.2
Merlie, J.P.3
Sanes, J.R.4
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63
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0001517943
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Hepatocyte growth factor/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons
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of special interest. Identification of a novel function for hepatocycte growth factor/scatter factor as a chemoattractant for motor neurons. The mouse knockout phenotype shows abnormalities of limb motor innervation.
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Ebens A, Brose K, Leonardo ED, Hanson MG, Bladt F, Birchmeier C, Barres BA, Tessier-Lavigne M. Hepatocyte growth factor/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons. of special interest Neuron. 17:1996;1157-1172 Identification of a novel function for hepatocycte growth factor/scatter factor as a chemoattractant for motor neurons. The mouse knockout phenotype shows abnormalities of limb motor innervation.
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(1996)
Neuron
, vol.17
, pp. 1157-1172
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-
Ebens, A.1
Brose, K.2
Leonardo, E.D.3
Hanson, M.G.4
Bladt, F.5
Birchmeier, C.6
Barres, B.A.7
Tessier-Lavigne, M.8
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64
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0030293971
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Chemosuppression of retinal axon growth by the mouse optic chiasm
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Wang L-C, Rachel RA, Marcus RC, Mason CA. Chemosuppression of retinal axon growth by the mouse optic chiasm. Neuron. 17:1996;849-862.
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(1996)
Neuron
, vol.17
, pp. 849-862
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Wang L-C1
Rachel, R.A.2
Marcus, R.C.3
Mason, C.A.4
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65
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0030918992
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Surround repulsion of spinal sensory axons in higher vertebrate embryos
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of special interest. This study uses explants of chick embryo DRGs and surrounding tissues in collagen gels to show that linear axon trajectories can be generated by gradients of diffusible repulsion molecules flanking axon pathways.
-
Keynes RJ, Tannahill D, Morgenstern DA, Johnson AR, Cook GMW, Pini A. Surround repulsion of spinal sensory axons in higher vertebrate embryos. of special interest Neuron. 18:1997;889-897 This study uses explants of chick embryo DRGs and surrounding tissues in collagen gels to show that linear axon trajectories can be generated by gradients of diffusible repulsion molecules flanking axon pathways.
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(1997)
Neuron
, vol.18
, pp. 889-897
-
-
Keynes, R.J.1
Tannahill, D.2
Morgenstern, D.A.3
Johnson, A.R.4
Cook, G.M.W.5
Pini, A.6
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66
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0030764519
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Genes that guide growth cones along the C. elegans ventral nerve cord
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Wightman B, Barab R, Garriga G. Genes that guide growth cones along the C. elegans ventral nerve cord. Development. 124:1997;2571-2580.
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(1997)
Development
, vol.124
, pp. 2571-2580
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Wightman, B.1
Barab, R.2
Garriga, G.3
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67
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12644270206
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Zebrafish mutations affecting retinotectal axon pathfinding
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of special interest. Shows the utility of the zebrafish in the identification of candidate guidance genes.
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Karlstrom RO, Trowe T, Klostermann S, Baier H, Brand M, Crawford AD, Grunewald B, Haffter P, Hoffmann H, Meyer SU, et al. Zebrafish mutations affecting retinotectal axon pathfinding. of special interest Development. 123:1996;427-438 Shows the utility of the zebrafish in the identification of candidate guidance genes.
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(1996)
Development
, vol.123
, pp. 427-438
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-
Karlstrom, R.O.1
Trowe, T.2
Klostermann, S.3
Baier, H.4
Brand, M.5
Crawford, A.D.6
Grunewald, B.7
Haffter, P.8
Hoffmann, H.9
Meyer, S.U.10
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68
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Diffusion in axon guidance
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Goodhill GJ. Diffusion in axon guidance. Eur J Neurosci. 9:1997;1414-1421.
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Eur J Neurosci
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Goodhill, G.J.1
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69
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Specific axon guidance factors persist in the adult brain as demonstrated by pig neuroblasts transplanted to the rat
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Isacson O, Deacon TW. Specific axon guidance factors persist in the adult brain as demonstrated by pig neuroblasts transplanted to the rat. Neuroscience. 75:1996;827-837.
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Neuroscience
, vol.75
, pp. 827-837
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Isacson, O.1
Deacon, T.W.2
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