Adhesion and signalling in axonal fasciculation

Current Opinion in Neurobiology

Volumn 8, Issue 1, 1998, Pages 80-86

  Van Vactor, David ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RECEPTOR; NERVE PROTEIN;

CELL ADHESION; FASCICULATION; GENETIC ANALYSIS; NERVE FIBER; NERVE FIBER GROWTH; NERVOUS SYSTEM DEVELOPMENT; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; BRAIN; CYTOLOGY; GROWTH, DEVELOPMENT AND AGING; HUMAN; PHYSIOLOGY;

ANIMALS; AXONS; BRAIN; HUMANS; NERVE TISSUE PROTEINS;

EID: 0031596769     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(98)80011-1     Document Type: Article

References (59)

1. Landmesser LT. The generation of neuromuscular specificity. Annu Rev Neurosci. 3:1980;279-302.
2. Goodman CS, Bastiani MJ, Doe CQ, du Lac S, Helfand SL, Kuwada JY, Thomas JB. Cell recognition during neuronal development. Science. 225:1984;1271-1279.
3. Weiss P. Nerve patterns: the mechanics of nerve growth. Growth, Third Growth Symp. 5:1941;163-203.
4. Letourneau PC. Cell-to-substratum adhesion and guidance of axonal elongation. Dev Biol. 44:1975;92-101.
5. Rutishauser U, Gall WE, Edelman GM. Adhesion among neural cells of the chick embryo. IV. Role of the cell surface molecule CAM in the formation of neurite bundles in cultures of spinal ganglia. J Cell Biol. 79:1978;382-393.
6. Jessell TM. Adhesion molecules and the hierarchy of neural development. Neuron. 1:1988;3-13.
7. Hynes RO, Lander AD. Contact and adhesive specificities in the associations, migrations and targeting of cells and axons. Cell. 68:1992;303-322.
8. Baldwin TJ, Fazeli MS, Doherty P, Walsh FS. Elucidation of the molecular actions of NCAM and structurally related cell adhesion molecules. J Cell Biochem. 61:1996;502-513.
9. 2+-dependent and -independent cell adhesion molecules. Proc Natl Acad Sci USA. 84:1987;2555-2559.
10. Edelman GM. Cell adhesion molecules in the regulation of animal form and tissue pattern. Annu Rev Cell Biol. 2:1986;81-116.
11. Cremer H, Lange R, Christoph A, Plomann M, Vopper G, Roes J, Brown R, Baldwin S, Kraemer P, Scheff S, et al. Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning. Nature. 367:1994;455-459.
12. Tomasiewicz H, Ono K, Yee D, Thompson C, Goridis C, Rutishauser U, Magnuson T. Genetic deletion of a neural cell adhesion molecule variant (N-CAM-180) produces distinct defects in the central nervous system. Neuron. 11:1993;1163-1174.
13. Treloar H, Tomasiewicz H, Magnuson T, Key B. The central pathway of primary olfactory axons is abnormal in mice lacking the N-CAM-180 isoform. J Neurobiol. 32:1997;643-658.
14. Doherty P, Fazeli MS, Walsh FS. The neural cell adhesion molecule and synaptic plasticity. J Neurobiol. 26:1994;437-446.
15. Grenningloh G, Rehm EJ, Goodman CS. Genetic analysis of growth cone guidance in Drosophila: fasciclin II functions as a neuronal recognition molecule. Cell. 67:1991;45-57.
16. Lin DM, Fetter RD, Kopczynski C, Grenningloh G, Goodman CS. Genetic analysis of fasciclin II in Drosophila: defasciculation, refasciculation and altered fasciculation. Neuron. 13:1994;1055-1069.
17. Lin DM, Goodman CS. Ectopic and increased expression of fasciclin II alters motoneuron growth cone guidance. Neuron. 13:1994;507-523.
18. Fambrough D, Goodman CS. The Drosophila beaten path gene encodes a novel secreted protein that regulates defasciculation at motor axon choice points. of outstanding interest Cell. 87:1996;1049-1058 Describes the cloning and expression of beaten path. Genetic interactions with different CAMs provide evidence that Beat acts to antagonize adhesive interactions through a novel mechanism.
19. Ramos RGP, Igloi GL, Lichte B, Baumann U, Maier D, Schneider T, Brandstatter JH, Frohlich A, Fischbach KF. The irregular chiasm C-roughest locus of Drosophila, which affects axonal projections and programmed cell death, encodes a novel immunoglobulin-like protein. Genes Dev. 7:1993;2533-2547.
20. Schneider T, Reiter C, Eule E, Bader B, Lichte B, Nie Z, Schimansky T, Ramos RGP, Fischback KF. Restricted expression of the irreC-rst protein is required for normal axonal projections of columnar visual neurons. Neuron. 15:1995;259-271.
21. Bieber AJ, Snow PM, Goodman CS. Drosophila neuroglian: a member of the immunoglobulin superfamily with extensive homology to the vertebrate neural adhesion molecule L1. Cell. 59:1989;447-460.
22. Hall SG, Bieber AJ. Mutations in the Drosophila neuroglian cell adhesion molecule affect motor neuron pathfinding and peripheral nervous system patterning. J Neurobiol. 32:1997;325-340.
23. Redies C, Takeichi M. Cadherins in the developing central nervous system: an adhesive code for segmental and functional subdivisions. Dev Biol. 180:1996;413-423.
24. Reihl R, Johnson K, Bradley R, Grunwald G, Cornel E, Lilienbaum A, Holt CE. Cadherin function is required for axon outgrowth in retinal ganglion cells in vivo. Neuron. 17:1996;837-848.
25. Iwai Y, Usui T, Hirano S, Steward R, Takeichi M, Uemura T. Axon patterning requires DN-cadherin, a novel neuronal adhesion receptor, in the Drosophila embryonic CNS. of outstanding interest Neuron. 19:1997;77-89 This paper describes the molecular and genetic characterization of the first neuronal cadherin in Drosophila (DN-cadherin). Phenotypic analysis within the developing CNS reveals that DN-cadherin mediates axonal fasciculation of a small population of CNS axons.
26. Hynes RO. Targeted mutations in cell adhesion genes: what have we learned from them? Dev Biol. 180:1996;402-412.
27. Fassler R, Georges-Labouesse E, Hirsch E. Genetic analysis of integrin function in mice. Curr Opin Cell Biol. 8:1996;641-646.
28. Baum PD, Garriga G. Neuronal migrations and axon fasciculation are disrupted in ina-1 integrin mutants. of outstanding interest Neuron. 19:1997;51-62 This genetic analysis of ina-1, a C. elegans α-integrin gene, shows that it is required for all neuronal migrations. Even though ina-1 mutants do not display defects in axon guidance, unexpectedly, fasciculation is abnormal in several axon pathways. This is the first in vivo evidence for an integrin function in axonal fasciculation despite genetic analyses in other systems.
29. Rutishauser U. Adhesion molecules of the nervous system. Curr Opin Neurobiol. 3:1993;709-715.
30. Rutishauser U, Landmesser L. Polysialic acid in the vertebrate nervous system: a promoter of plasticity in cell-cell interactions. Trends Neurosci. 19:1996;422-427.
31. Tang J, Landmesser L, Rutishauser U. Polysialic acid influences specific pathfinding by avian motoneurons. Neuron. 8:1992;1031-1044.
32. Tang J, Rutishauser U, Landmesser L. Polysialic acid regulates growth cone behavior during sorting of motor axons in the plexus region. Neuron. 13:1994;405-414.
33. Ball EE, Ho RK, Goodman CS. Development of neuromuscular specificity in the grasshopper embryo: guidance of motoneuron growth cones by muscle pioneers. J Neurosci. 5:1985;1808-1819.
34. Prokop A, Landgraf M, Rushton E, Broadie K, Bate M. Presynaptic development at the Drosophila neuromuscular junction: assembly and localization of presynaptic active zones. Neuron. 17:1996;617-626.
35. Van Vactor D, Sink H, Fambrough D, Tsoo R, Goodman CS. Genes that control neuromuscular specificity in Drosophila. Cell. 73:1993;1137-1153.
36. Desai CJ, Gindhart JG, Goldstein LSB, Zinn K. Receptor tyrosine phosphatases are required for motor axon guidance in the Drosophila embryo. of outstanding interest Cell. 84:1996;599-609 Double- and single-mutant analyses show that DPTP69D and DPTP99A cooperate to control the fasciculation of embryonic motor axons. This and a companion paper [56] provide the first evidence that RPTPs function to control axon guidance and fasciculation.
37. Mushegian AR. The Drosophila Beat protein is related to adhesion proteins that contain immunoglobulin domains. of special interest Curr Biol. 7:1997;R336-R338 Highly sensitive sequence comparison analysis reveals that Drosophila Beat contains two domains related to members of the Ig superfamily and that related vertebrate sequences exist within the expressed sequence tag (EST) database, suggesting that this mechanism for modulating cell - cell interactions has been evolutionarily conserved. See also [38].
38. Bazan JF, Goodman CS. Molecular structure of the Drosophila Beat protein. of special interest Curr Biol. 7:1997;R338-R339 This companion paper to [37] describes similar sequence analysis for Beat; however, in addition to the Ig domains, a carboxy-terminal cysteine-knot domain is described. The cysteine knot, which is capable of promoting dimerization, is characteristic of several secreted growth factors; this structure has interesting implications for the Beat mechanism.
39. Beggs HE, Soriano P, Maness PF. NCAM-dependent neurite outgrowth is inhibited in neurons from Fyn-minus mice. J Cell Biol. 127:1994;825-833.
40. Ignelzi MA, Miller DR, Soriano P, Maness PF. Impaired neurite outgrowth of src-minus cerebellar neurons on the cell adhesion molecule L1. Neuron. 12:1994;873-884.
41. rsk in neurite outgrowth mediated by the cell adhesion molecule L1. J Biol Chem. 271:1996;18217-18223.
42. Williams EJ, Furness J, Walsh FS, Doherty P. Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin. Neuron. 13:1994;583-594.
43. of special interest Saffell JL, Williams EJ, Mason IJ, Walsh FS, Doherty P. Expression of a dominant negative FGF receptor inhibits axonal growth and FGF receptor phosphorylation stimulated by CAMs. of outstanding interest Neuron. 18:1997;231-242 Functional and biochemical studies of CAMs and the FGFR suggest that CAM binding elicits axon outgrowth by activating FGFR phosphorylation. This provides a striking demonstration of CAM-induced signaling, and supports data from other papers (e.g. [44]), suggesting a role for FGFR in controlling axonal development.
44. McFarlane S, Cornel E, Amaya E, Holt CE. Inhibition of FGF receptor activity in retinal ganglion cell axons causes errors in target recognition. of special interest Neuron. 17:1996;245-254 Expression of dominant-negative FGFR during retinal ganglion cell development suggests that FGFR is required for both outgrowth and guidance of these axons in vivo.
45. Callahan CA, Muralldhar MG, Lungren SE, Scully AL, Thomas JB. Control of neuronal pathway selection by a Drosophila receptor protein-tyrosine kinase family member. Nature. 376:1995;171-174.
46. Flanagan JG, Vanderhaegen P. The ephrins and Eph receptors in neural development. Annu Rev Neurosci. 21:1998;309-345.
47. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Cell. 90:1997;403-404.
48. Winslow JW, Moran P, Valverde J, Shih A, Yuan JQ, Wong SC, Tsai SP, Goddard A, Henzel WJ, Hefti F, et al. Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation. Neuron. 14:1995;973-981.
49. Henkemeyer M, Orioli D, Henderson JT, Saxton TM, Roder J, Pawson T, Klein R. Nuk controls pathfinding of commissural axons in the mammalian central nervous system. of outstanding interest Cell. 86:1996;35-46 The mouse knock-out of the Nuk Eph receptor reveals a role in the formation of the anterior commissure (AC); this phenotype is rescued by a fusion protein lacking most of the Nuk intracellular domain, indicating that intrinsic tyrosine kinase activity is not required for Nuk function in the AC.
50. Orioli D, Henkemeyer M, Lemke G, Klein R, Pawson T. Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. of outstanding interest EMBO J. 15:1996;6035-6049 Double-mutant analysis reveals complexity in the function of Sek4 and Nuk Eph receptors. Although each receptor is essential for certain axon pathfinding functions, mutations in both receptors are required to disrupt axon fasciculation patterns, suggesting some level of redundancy.
51. Zisch AH, Stallcup WB, Chong LD, Dahlin-Huppe K, Voshol J, Schachner M, Pasquale EB. Tyrosine phosphorylation of L1 family adhesion molecules: implication of the Eph kinase Cek5. J Neurosci Res. 47:1997;655-665.
52. Bruckner K, Pasquale E, Klein R. Tyrosine phosphorylation of transmembrane ligands for Eph receptors. of special interest Science. 275:1997;1640-1642 The observation that the transmembrane ephrin Lerk2 is rapidly phosphorylated after exposure to the Cek5 extracellular domain suggests that Eph receptor signaling may work in both directions.
53. Van Vactor D. Tyrosine phosphatases in the nervous system. of special interest Curr Opin Cell Biol. 10:1998; This recent review covers the expression of many PTP family members in the developing nervous system, a topic not covered well in other recent reviews.
54. Van Vactor D, O'Reilly AM, Neel BG. Genetic analysis of protein tyrosine phosphatase function. of special interest Curr Opin Genet Dev. 8:1998; This recent review provides a thorough resource on the topic of PTP function and signaling in a variety of experimental systems, with an emphasis on genetic analyses.
55. Yeo TT, Yang T, Massa SM, Zhang JS, Honkaniemi J, Butcher LL, Longo FM. Deficient LAR expression decreases basal forebrain cholinergic size and hippocampal cholinergic innervation. J Neurosci Res. 47:1997;348-360.
56. Krueger NX, Van Vactor D, Wan HI, Gelbart WM, Goodman CS, Saito H. The transmembrane tyrosine phosphatase DLAR controls motor axons guidance in Drosophila. of outstanding interest Cell. 84:1996;611-622 A genetic analysis of Dlar function shows that this Drosophila RPTP is required in neurons for the guidance of specific motor axons into their normal target regions. This and a companion paper [36] provide the first evidence that RPTPs play an important role in controlling specific axon guidance decisions in vivo.
57. Desai CJ, Krueger NX, Saito H, Zinn K. Competition and cooperation among receptor tyrosine phosphatases control growth cone guidance in Drosophila. of special interest Development. 124:1997;1941-1952 Further to [36], this phenotypic analysis reveals complex interactions between Dlar, DPTP69D and DPTP99A; depending on the context, these RPTPs may support or antagonize each other.
58. Tessier-Lavigne M, Goodman CS. The molecular biology of axon guidance. Science. 274:1996;1123-1133.
59. Speicher S, Garcia-Alonso L, Carmena A, Martin-Bermudo MD, de la Escalera S, Jimenez F. Neurotactin functions in concert with other identified CAMs in growth cone guidance in Drosophila. Neuron. 20:1998;221-233.