First-pass effect: Significance of the intestine for absorption and metabolism

Drug and Chemical Toxicology

Volumn 20, Issue 4, 1997, Pages 329-344

  Doherty, Margaret M ^a   Pang, K Sandy ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CARRIER PROTEIN; CELIPROLOL; CYCLOSPORIN; DAUNORUBICIN; DIGOXIN; ENALAPRIL; GENTISAMIDE; GLYCOPROTEIN P; HYMECROMONE; MIDAZOLAM; MORPHINE; PAFENOLOL; PARACETAMOL; QUINIDINE; RHODAMINE; SALICYLAMIDE; SOTALOL; TACROLIMUS; TALINOLOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CONFERENCE PAPER; DRUG BIOAVAILABILITY; DRUG CONJUGATION; DRUG ELIMINATION; DRUG HYDROLYSIS; DRUG OXIDATION; DRUG PENETRATION; DRUG SOLUBILITY; FIRST PASS EFFECT; LIVER METABOLISM; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SMALL INTESTINE ABSORPTION;

ANIMALIA;

EID: 0031416567     PISSN: 01480545     EISSN: None     Source Type: Journal    
DOI: 10.3109/01480549709003891     Document Type: Conference Paper

References (97)

1. C.C. Lang, R.M. Brown, M.T. Kinirons, M-A. Deathridge, F.P. Guengerich, D. Kelleher, D.S. O'Briain, F.K. Ghishan and A.J. Wood, Clin. Pharmacol. Ther., 59, 41 1996.
2. P.H. Marathe, D.E. Salazar, D.S. Greene, J. Brennan, U.A. Shukla and R.H Barbhaiya, Pharm. Res., 12, 1716 1995.
3. K.J. Rich, D. Sesardic, J.R. Foster, D.S. Davies and A.R. Boobis, Biochem. Pharmacol., 38, 3305 1989.
4. D.W. Piper and B.H. Fenton, Clin. Chim. Acta., 24, 215 1969.
5. M. Mistry and J.B. Houston, Drug. Metab. Dispos., 15, 710 1987.
6. A. Lampen, U. Christians, F. Guengerich, P. Watkins, J. Kolars, A. Bader, A-K. Gonschior, H. Dralle, I. Hackbarth and K. Sewing, Drug. Metab. Dispos., 23, 1315 1995.
7. Y. Tomita, T. Katsura, T. Okano, K. Inui and R. Hori, J. Pharmacol. Exp. Ther., 252, 859 1990.
8. Y-Z. Gong, P.P. Zwarych, M.C. Lin and F.A. Wilson, Biochem. Biophys. Res. Comm., 179, 204 1991.
9. H. Yuasa, D. Fleisher and G.L. Amidon, J. Pharmacol. Exp. Ther., 269, 1107 1994.
10. R. Tanabe, M. Kobayashi, M. Sugawara, K. Iseki and K. Miyazaki, J. Pharm. Pharmacol., 48, 517 1996.
11. M. Hu and R.T. Borchardt, Pharm. Res., 7, 1313 1990.
12. L. Zheng, J. Chen, Y. Zhu, H. Yang, W. Elmquist and M. Hu, Pharm. Res., 11, 1771 1994.
13. A. Tsuji, H. Takanaga, I. Tamai and T. Terasaki, Pharm Res., 11, 30 1994.
14. C.L. Crespi, B.W. Penman and M. Hu, Pharm. Res., 13, 1635 1996.
15. G.M. Pauletti, F.W. Okumu and R.T. Borchardt, Pharm. Res., 14, 164 1997.
16. A. Wikman, J. Karlsson, I. Carlstedt and P. Artursson, Pharm. Res., 10, 843 1993.
17. K. Ming, Y. Covitz, G.L. Amidon and W. Sadee, Pharm. Res., 13, 1631 1996.
18. G.L Amidon, G.D. Leesman and R.L Elliott, J. Pharm. Sci., 69, 1363 1980.
19. I. Osiecka, M. Cortese, P.A. Porter, R.T. Borchardt, J.A. Fix and C.R. Gardner, J. Pharmacol. Exp. Ther., 242, 443 1987.
20. P.J. Sinko and G.L. Amidon Pharm. Res., 5, 645 1988.
21. W. Barr and S. Riegelman, J. Pharm. Sci., 59, 154 1970.
22. S.H. Curry, A. D'Mello and G.P. Mould, Br. J. Pharmac. 42, 403 1971.
23. S.M. Rogers, D.J. Back and M.L, E. Orme, Br. J. Pharmac., 23, 727 1987.
24. A. Lampen, U. Christians, A.K. Gonschior, A. Bader, I. Hackbarth, W. von Engelhardt and K.T. Sewing, Br. J. Pharmac., 117, 1730 1996.
25. H. Saitoh, H. Fujisaki, B.J. Aungst and K. Miyazaki, Pharm. Res., 14, 645 1997.
26. S. Yamashita, Y. Tanaka, Y. Endoh, Y. Taki, T. Sakane, T. Nadai and S. Hitoshi, Pharm. Res., 14, 486 1997.
27. K Sakai, M. Akima, Y. Hinohara, M. Sasaki and R. Niki, Japan. J. Pharmacol., 30, 231 1980.
28. H. Hirayama, X. Xu and K.S. Pang, Am. J. Physiol., 257, G249 1989.
29. P.C. Adams and D.E. Rickert, Biopharm. Drug. Dispos., 17, 675 1996.
30. J. Chen and K.S. Pang, J. Pharm. Exp. Ther., 280, 24 1997.
31. K.S. Pang, W.F. Cherry and E.H. Ulm, J. Pharmacol. Exp. Ther., 233, 788 1985.
32. X. Xu, H. Hirayama and K.S. Pang, Drug . Metab. Dispos., 17, 556 1989.
33. H. Hirayama and K.S. Pang, Drug. Metab. Dispos., 18, 580 1990.
34. R. Gugler, P. Lain and D.L. Azarnoff, J. Pharmacol. Exp. Ther., 195, 416 1975.
35. M-W. Lo, S.M. Pond, D.J. Effeney, B.M. Silber, S. Riegelman and T.N. Tozer, J. Pharmacokin. Biopharm., 12, 401 1984.
36. M.K. Cassidy and J.B. Houston, Drug. Metab. Dispos., 12, 619 1984.
37. A.A. Raoof, P.F. Augustijns and R.K. Verbeeck, Pharm Res., 13, 891 1996.
38. A.T. Florence, Pharm. Res., 14, 259 1997.
39. Y-L. He, S. Murby, L. Gifford, A. Collett, G. Warhurst, K.T. Douglas, M. Rowland and J. Ayrton, Pharm. Res., 13, 1673 1996.
40. M.E. Lane, C.M. O'Driscoll and O.I. Corrigan, Pharm Res., 13, 1334 1996.
41. P. Shore, B.B. Brodie and C.A.M. Hogben, J Pharmacol. Exp. Ther., 119, 36 1957.
42. A. Lindahl, A-L. Ungell, L. Knutson and H. Lennernas, Pharm. Res., 14, 497 1997.
43. G.P. Martin, C. Marriott and I.W. Kellaway, Gut., 19, 103 1978.
44. R.W. Freel, M. Hatch, E.L. Earnest and A.M. Goldner, Am. J. Physiol., 245, G816 1983.
45. B.G. Boggiano and M. Gleeson, J. Pharm. Sci., 65, 497 1976.
46. J.M. Blaha, A.M. Knevel, D.P. Kessler, J.W. Mincy and S.L. Hem, J. Pharm. Sci., 65, 1165 1976.
47. W.S. Nimmo, Clin. Pharmacokinet., 1, 189 1976.
48. A.C. Guyton and J.E Hall, Textbook of Medical Physiology, W.B. Saunders Company, Philadelphia, 1996.
49. I. Komiya, J.Y. Park, A. Kamani, N.F.H. Ho and W.I. Higuchi, Int. J. Pharm., 4, 249 1980.
50. E. Nakashima, A. Tsuji, S. Kagatani and T. Yamana, J. Pharm. Dyn., 7, 452 1984.
51. M. Hu and G.I. Amidon, J. Pharm. Sci., 77, 1007 1988.
52. D.I. Friedman and G.I. Amidon, Pharm. Res., 6, 1043 1989.
53. W. Kramer, F. Girbif, H. Gutjahr, W. Kleeman, I. Leipe, H. Urbach and A. Wagner, Biochim. Biophys. Acta., 1027, 25 1990.
54. B. Mackenzie, D.D.F. Loo, Y-J. Fei, W. Liu, V. Ganapathy, F.H. Leibach and E.M. Wright, J. Biol. Chem., 271, 5430 1996.
55. M. Hu, J. Pharm. Sci. 8, 829 1993.
56. A.P. Waclawski and P.J. Sinko, J. Pharm. Sci., 85, 478 1996.
57. M.J. Moll-Navarro, M. Merino, V.G Casabo, A. Nacher and A. Polache, J. Pharm. Sci., 85, 1248 1996.
58. C-K. Garcia, J.L. Goldstein, R.K. Pathak, R.G.W. Anderson and M.S. Brown, Cell, 76, 865 1994.
59. F.K. Ghishan, H.M. Said, P.C. Wilson, J.E. Murrell and H.L. Greene, Am. J. Clin. Nutr., 43, 258 1986.
60. M.C. Lin, Y. Gong, K.F. Geoghegan and F.A. Wilson, Biochim. Biophys. Acta., 1078, 329 1991.
61. H. Saitoh, M. Kobayashi, M. Sugawara, K. Iseki and K. Miyazaki, Biochim. Biophys. Acta., 1112, 153 1992.
62. A. Tsuji and I. Tamai, Pharm. Res., 13, 963 1996.
63. M. Kagedahl, P.W. Swaan, C.T. Redemann, M. Tang, C.S. Craik, F.C. Szoka and S. Øie, Pharm. Res., 80, 176 1997.
64. M.E. Taub, B.D. Larsen, B. Steffansen and S. Frokjaar, Int. J. Pharm., 146, 205 1997.
65. B.L. Leu and J-D. Huang, Cancer. Chemother. Pharmacol., 35, 432 1995.
66. L.J. Goldstein, I. Pastan and M.M. Gottesman, Crit. Rev. Oncol. Hematol., 12, 243 1992.
67. H. Saitoh and B.J. Aungst, Pharm. Res., 12, 1304 1995.
68. S. Hsing, Z. Gatmaitan and I.M. Arias, Gastroenterology., 102, 879 1992.
69. J. Hunter, M.A. Jepson, T. Tsuruo, N.L. Simmons and B.H. Hirst, J. Biol. Chem., 268, 14991 1993.
70. S-F. Su and J-D. Huang, Drug. Metab. Dispos., 2, 142 1996.
71. R.A. Carr, F.M. Pasutto and R.T. Foster, Biopharm. Drug. Dispos., 17, 725 1996.
72. H. Lennernas and C-G. Regardh, Pharm. Res., 10, 727 1993.
73. S-M. Kuo, B.R. Whitby, P. Artursson and J.A. Ziernniak, Pharm. Res., 11, 648 1994.
74. U. Wetterich, H. Spahn-Langguth, E. Mutschler, B. Terhaag, W. Rosch and P. Langguth, Pharm. Res., 13, 514 1996.
75. T. Gramatte, R. Oertel, B. Terhaag and W. Kirch, Clin. Pharmacol. Ther., 59, 541 1996.
76. J.R. Dawson and J.W. Bridges, Biochem. Pharmacol., 30, 2415 1981.
77. K.F. Ilett, L.B.G. Tee, P.T. Reeves and R.F. Minchin, Pharmacol. Ther., 46, 67 1990.
78. C.T. Walsh and R.T. Levine, J. Pharmacol. Exp. Ther., 195, 303 1975.
79. D.R. Krishna and U. Klotz, Clin. Pharmacokinet., 26, 144 1994.
80. D.A. Johnson and G.L. Amidon, J. Pharm. Sci., 75, 195 1986.
81. M.F. Hebert, J.P. Roberts, T. Prueksaritanont and L.Z. Benet, Clin. Pharmacol. Ther., 52, 452 1992.
82. S.K. Gupta, A. Bakran, R.W.G. Johnson and M. Rowland, Br. J. Clin. Pharmacol., 25, 401 1988.
83. D.Y. Gomez, V.J. Wacher, S.J. Tomlanovich, M.F. Hebert and L.Z. Benet, Clin. Pharmacol. Ther., 58, 15 1995.
84. J.B. Dressman and D. Fleisher, J. Pharm. Sci., 75, 109 1986.
85. G.L. Amidon, P.J. Sinko and D. Fleisher, Pharm. Res., 5, 651 1988.
86. P.J. Sinko, G.D. Leesman and G.L. Amidon, Pharm. Res., 8, 979 1991.
87. W.L. Chiou, Biopharm. Drug. Dispos., 15, 709 1994.
88. M. Gibaldi and D. Perrier, Pharamcokinetics, Marcel Dekker Inc., New York, 1982.
89. M.F. Paine, D.D. Shen, K.L. Kunze, J.D. Perkins, C.L. Marsh, J.P. McVicar, D.M. Barr, B.S. Gillies and K.E. Thummel, Clin. Pharmacol. Ther., 60, 14 1996.
90. K.E. Thummel, D. O'Shea, M.F. Paine, D.D. Shen, K.L. Kunze, J.D. Perkins and G.R. Wilkinson, Clin. Pharmacol. Ther., 59, 491 1996.
91. M.P. Ducharme, L.H. Warbasse and D.J. Edwards, Clin. Pharmacol. Ther., 57, 485 1995.
92. K.S. Pang, V. Yuen, S, Fayz, J.M. Te Koppele and G.J. Mulder, Drug. Metab. Dispos., 14, 102 1986.
93. M.M. Doherty, K, Poon, and K.S, Pang, The Pharmacologist, 39, 76 1997.
94. J.X. Mazoit, P. Sandouk, J.M. Schermann and A. Roche, Clin. Pharmacol. Ther., 48, 613 1990.
95. C. Zimmerman, S. Ratna, E. LeBoeuf and K.S. Pang, J. Chromatogr., 563, 83 1991.
96. S.K. Podder, T. Nakamura, M. Nakashima, H. Sasaki, J. Nakamura and L. Shibasaki, J. Pharmacobio-Dyn., 11, 324 1988.
97. G.T. Mulder, S. Brouwer, J.G. Weitering, E. Scholtens and K.S. Pang, Biochem. Pharmacol., 34, 1325 1985.