Limitations of hepatocytes and liver homogenates in modelling in vivo formation of acyl glucuronide-derived drug-protein adducts

Journal of Pharmacological and Toxicological Methods

Volumn 41, Issue 1, 1999, Pages 27-32

  Bailey, Mark J ^a   Dickinson, Ronald G ^a  

^a NONE

Author keywords

Acyl glucuronides; Drug protein adducts; Hepatocytes; Reactivity; Zomepirac

Indexed keywords

ZOMEPIRAC;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; COVALENT BOND; DRUG PROTEIN BINDING; INTRAVENOUS DRUG ADMINISTRATION; LIVER CELL; LIVER METABOLISM; MALE; MORPHOLOGY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; RAT; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BINDING, COMPETITIVE; BLOTTING, WESTERN; CELLS, CULTURED; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLUCURONATES; GLYCOSYLATION; LIVER; MALE; PROTEIN BINDING; RATS; RATS, WISTAR; TOLMETIN;

ANIMALIA;

EID: 0032828355     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1056-8719(99)00014-3     Document Type: Article

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