Chemical mapping of anxiety in the brain of healthy humans: An in vivo 1H-MRS study on the effects of sex, age, and brain region

Human Brain Mapping

Volumn 11, Issue 4, 2000, Pages 261-272

  Grachev, Igor D ^a   Vania Apkarian, A ^a  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

Author keywords

Age differences; Anxiety; Brain chemistry; Healthy humans; In vivo proton magnetic resonance spectroscopy; N Acetyl aspartate; Neurotransmitters; Orbital frontal cortex; Sex differences; State Trait Anxiety Inventory

Indexed keywords

AGE; ANXIETY; ARTICLE; BRAIN MAPPING; BRAIN REGION; DAILY LIFE ACTIVITY; FRONTAL CORTEX; HUMAN; HUMAN EXPERIMENT; NEUROCHEMISTRY; NORMAL HUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SEX DIFFERENCE; STATISTICAL ANALYSIS;

ADULT; AGING; ANXIETY; ASPARTIC ACID; BRAIN; BRAIN CHEMISTRY; FEMALE; FRONTAL LOBE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; ORBIT; OSMOLAR CONCENTRATION; REFERENCE VALUES; SEX CHARACTERISTICS; TISSUE DISTRIBUTION;

EID: 0033647462     PISSN: 10659471     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0193(200012)11:4<261::AID-HBM30>3.0.CO;2-6     Document Type: Article

References (55)

1. Anxiety: At the intersection of genes and experience
2. A short echo 1H spectroscopy and volumetric MRI study of the corpus striatum in patients with obsessive-compulsive disorder and comparison subjects
3. Cerebral glucose metabolic rates in nondepressed patients with obsessive-compulsive disorder
4. Biochemical hypotheses of mood and anxiety disorders
5. Insensitivity to future consequences following damage to human prefrontal cortex
6. Deciding advantageously before knowing the advantageous strategy
7. Dissociation of working memory within the human prefrontal cortex
8. Functional neuroanatomy of CCK4-induced anxiety in normal healthy volunteers
9. Functional magnetic resonance imaging of symptom provocation in obsessive-compulsive disorder
10. Age differences in depression and anxiety symptoms: A structural Equation modeling analysis of data from a general population sample
11. Generalized anxiety disorder: Neurobiological and pharmacotherapeutic perspectives
12. Brain circuits in panic disorder
13. Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues
14. The somatic marker hypothesis and the possible functions of the prefrontal cortex
15. Regional brain function, emotion and disorders of emotion
16. 1H-magnetic resonance spectroscopy in obsessive-compulsive disorder: Evidence for neuronal loss in the cingulate gyrus and the right striatum
17. N-Acetyl aspartic acid (NAA) and N-Acetyl aspartylglutamic acid (NAAG) in human ventricular, subarachnoid, and lumbar cerebrospinal fluid
18. Proton spectroscopic imaging of the thalamus in treatment-naive pediatric obsessive-compulsive disorder
19. Epidemiology and comorbidity of anxiety disorders in the elderly
20. Epidemiology and comorbidity of anxiety disorders in later life: Implications for treatment
21. Structural abnormalities of frontal neocortex in obsessive-compulsive disorder
22. Anxiety in healthy humans is associated with orbital frontal chemistry
23. 1H-MRS study of young vs. middle-aged subjects
24. Chemical heterogeneity of the living human brain: A proton MR spectroscopy study on the effects of sex, age and brain region
25. 1H NMR studies of glucose transport in the human brain
26. Hormonal interventions with psychopharmacological potential: An overview
27. Generalized anxiety disorder in women. A population-based twin study
28. The genetic epidemiology of phobias in women. The interrelationship of agoraphobia, social phobia, situational phobia, and simple phobia
29. The structure of the genetic and environmental risk factors for six major psychiatric disorders in women. Phobia, generalized anxiety disorder, panic disorder, bulimia, major depression, and alcoholism
30. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey
31. Progesterone: Does it affect response to drug?
32. Agoraphobia, simple phobia, and social phobia in the National Comorbidity Survey
33. Energy on demand
34. Neurosteroids: Endogenous bimodal modulators of the GABA-A receptor mechanism of action and physiological significance
35. Decreased brain GABA(A)-benzodiazepine receptor binding in panic disorder: Preliminary results from a quantitative PET study
36. Absolute concentrations of metabolites in the adult human brain in vivo: Quantification of localized proton MR spectra
37. 1H NMR spectroscopy: N-acetyl-L-aspartate, creatine, and choline
38. The functional anatomy, neurochemistry, and pharmacology of anxiety
39. Cerebral glucose metabolic rates in obsessive compulsive disorder
40. Comparison of prefrontal architecture and connections
41. Gender differences in the epidemiology and treatment of anxiety disorders
42. A symptom provocation study of posttraumatic stress disorder using positron emission tomography and script-driven imagery
43. A positron emission tomographic study of simple phobic symptom provocation
44. Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography
45. The application of positron emission tomography to the study of normal and pathologic emotions
46. The orbitofrontal cortex
47. The impact of different doses of estrogen and progestin on mood and sexual behavior in post-menopausal women
48. Interpreting functional imaging studies in terms of neurotransmitter cycling
49. Stoichiometric coupling of brain glusose metabolism and glutamatergic neuronal activity
50. Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder
51. Gender differences in the presentation and management of social anxiety disorder
52. The cross-national epidemiology of panic disorder