N-acetyl aspartic acid (NAA) and N-acetyl aspartylglutamic acid (NAAG) in human ventricular, subarachnoid, and lumbar cerebrospinal fluid

Neurochemical Research

Volumn 24, Issue 10, 1999, Pages 1249-1261

  Faull, Kym F ^a   Rafie, Ramin ^a   Pascoe, Nina ^b   Marsh, Laura ^c   Pfefferbaum, Adolf ^d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d SRI INTERNATIONAL   (United States)

Author keywords

Cerebrospinal fluid; CSF; GC MS; HPLC; N Acetylaspartic acid; N acetylaspartylglutamic acid; Neuronal degeneration

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; HOMOVANILLIC ACID; N ACETYLASPARTIC ACID; N ACETYLASPARTYLGLUTAMIC ACID; NEUROLEPTIC AGENT; PROBENECID; ASPARTIC ACID; DIPEPTIDE; DRUG DERIVATIVE; N ACETYL 1 ASPARTYLGLUTAMIC ACID; N-ACETYL-1-ASPARTYLGLUTAMIC ACID; N-ACETYLASPARTATE;

ADULT; AGED; ARTICLE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; GAS CHROMATOGRAPHY; HUMAN; MALE; MASS SPECTROMETRY; NERVE CELL DEGENERATION; PRIORITY JOURNAL; BRAIN VENTRICLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LUMBAR VERTEBRA; MASS FRAGMENTOGRAPHY; MIDDLE AGED; SUBARACHNOID SPACE; ULTRAVIOLET SPECTROPHOTOMETRY;

ADULT; ASPARTIC ACID; CEREBRAL VENTRICLES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIPEPTIDES; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; SPECTROPHOTOMETRY, ULTRAVIOLET; SUBARACHNOID SPACE;

EID: 0032588848     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020973023059     Document Type: Article

References (68)

1. Tallan, H. H. 1957. Studies on the distribution of N-acetyl-L-aspartate acid in brain. J. Biol. Chem., 224:41-45.
2. 1H-NMR spectroscopic studies of brain. Neurosci. Biobehav. Rev., 13:23-31.
3. Tsai, G., and Coyle, J. T. 1995. N-Acetylaspartate in neuropsychiatric disorders. Prog. Neurobiol., 46:531-540.
4. Clark, J. B. 1998. N-Acetylaspartate: A marker for neuronal loss or mitochondrial dysfunction. Dev. Neurosci., 20:271-276.
5. Koller, K. J., and Coyle, J. T. 1984. Ontogenesis of N-acetyl-aspartate and N-acetyl-aspartyl-glutamate in rat brain. Dev. Brain Res., 15:137-140.
6. Koller, K. J., Zaczek, R., and Coyle, J. T. 1984. N-Acetyl-aspartyl-glutamate; Regional levels in rat brain and the effects of brain lesions as determined by a new HPLC method. J. Neurochem., 43:1136-1142.
7. Kwo-On-Yuen, P. F., Newmark, R. D., Budinger, T. F., Kaye, J. A., Ball, M. J., and Jagust, W. J. 1994. Brain N-acetyl-L-apartic acid in Alzheimer's disease: a proton magnetic resonance spectroscopy study. Brain Research, 667:167-174.
8. Pfefferbaum, A., Faull, K. F., Pascoe, N., Rafie, R., and Jagust, W. N-Acetyl proton MRS signal and HPLC NAA concentrations in the same samples of human brain extracts. Submitted.
9. Ory-Lavollee, L., Blakely, R. D., and Coyle, J. T. 1987. Neurochemical and immunocytochemical studies on the distribution of N-acetyl-aspartylglutamate and N-acetyl-aspartate in rat spinal cord and some peripheral nervous tissues. J. Neurochem., 48:895-899.
10. Simmons, M. L., Frondoza, C. G., and Coyle, J. T. 1991. Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies. Neuroscience, 45:37-45.
11. Kvittingen, E. A., Guldal, G., Borsting, S., Skalpe, I. O., Stokke, O., and Jellum, E. 1986. N-Acetylaspartic aciduria in a child with a progressive cerebral atrophy. Clin. Chim. Acta., 158:217-227.
12. Hagenfeldt, L., Bollgren, I., and Venizelos, N. 1987. N-Acetylas-partic aciduria due to aspartoacylase deficiency - a new etiology of childhood leukodystrophy. J. Inher. Metab. Dis., 10:135-141.
13. Divry, P., Vianey-Liaud, C., Gay, C., Macabeo, V., Rapin, F., and Echenne, B. 1988. N-Acetylaspartic aciduria: report of three new cases in children with a neurological syndrome associating macrocephaly and leukodystrophy. J. Inher. Metab. Dis., 11: 307-308.
14. Matalon, R., Michals, K., Sebesta, D., Deanching, M., Gaschkoff, P., and Casanova, J. 1988. Aspartocyclase deficiency and N-acetylaspartic aciduria in patients with Canavan disease. Am. J. Med. Genet., 29:463-471.
15. D'Adamo, Jr., A. F., and Yatsu, F. M. 1966. Acetate metabolism in the nervous system. N-Acetyl-L-aspartic acid and the biosynthesis of brain lipids. J. Neurochem., 13:961-965.
16. D'Adamo, Jr., A. F., Gidez, L. I., and Yatsu, F. M. 1968. Acetyl transport mechanisms. Involvement of N-acetyl aspartic acid in de novo fatty acid biosynthesis in the developing rat brain. Exptl. Brain Res., 5:267-273.
17. Burri, R., Steffen, C., and Herschkowitz, N. 1991. N-Acetyl-L-aspartate is a major source of acetyl groups for lipid synthesis during rat brain development. Dev. Neurosci., 13:403-411.
18. Shigematsu, H., Okamura, N., Shimeno, H., Kishimoto, Y., Kan, L-s., and Fenselau, C. 1983. Purification and characterization of the heat-stable factors essential for the conversion of lignoceric acid to cerebronic acid and glutamic acid: Identification of N-acetyl-L-aspartic acid. J. Neurochem., 40:814-820.
19. 14C from glucose into N-acetyl-L-aspartic acid and aspartic acid in brain perfusion experiments. J. Neurochem., 5:379-382.
20. McIntosh, J. C., and Cooper, J. R. 1965. Studies on the function of N-acetyl aspartic acid in brain. J. Neurochem., 12:825-835.
21. Truckenmiller, M. E., Namboodiri, M. A. A., Brownstein, M. J., and Neale, J. H. 1985. N-Acetylation of L-aspartate in the nervous system: Differential distribution of a specific enzyme. J. Neurochem., 45:1658-1662.
22. Taylor, D. L., Davies, S. E. C., Obrenovitch, T. P., Doheny, M. H., Patsalos, P. N., Clark, J. B., and Symon, L. 1995. Investigation into the role of N-acetylaspartate in cerebral osmoregulation. J. Neurochem., 65:275-281
23. McIlwain, H. 1959. Biochemistry and the central nervous system, Churchill, London.
24. Jacobson, K. B. 1959. Studies on the role of N-acetylaspartic acid in mammalian brain. J. Gen. Physiol., 43:323-333.
25. Curtis, D. R., and Watkins, J. C. 1960. The excitation and depression of spinal neurones by structurally related amino acids. J. Neurochem., 6:117-141.
26. Rubin, Y., LaPlaca, M. C., Smith, D. H., Thibault, L. E., and Lenkinski, R. E. 1995. The effect of N-acetylaspartate on the intracellular free calcium concentration in NTera2-neurons. Neuroscience Letters, 198:209-212.
27. Curatolo, A., D'Arcangelo, P., Lino, A., and Brancati, A. 1965. Distribution of N-acetyl-aspartic and N-acetyl-aspartyl-glutamic acids in nervous tissue. J. Neurochem., 12:339-342.
28. Miyamoto, E., Kakimoto, Y., and Sano, I. 1966. Identification of N-acetyl-a-aspartylglutamic acid in the bovine brain. J. Neurochem., 13:999-1003.
29. Blakely, R. D., and Coyle, J. T. 1988. The neurobiology of N-acetylaspartylglutamate. Int. Rev. Neurobiol., 30:39-100.
30. Coyle, J. T. 1997. The nagging question of the function on N-acetylaspartylglutamate. Neurobiology of Disease, 4:231-238.
31. Miyake, M., Kakimoto, Y., and Sorimachi, M. 1981. A gas Chromatographic method for the determination of N-acetyl-L-aspartic acid, N-acetyl-α-aspartylglutamic acid and β-citryl-L-glutamic acid and their distributions in the brain and other organs of various species of animals. J. Neurochem., 36:804-810.
32. Tsai, G., Goff, D. C., Chang, R. W., Flood J., Baer, L., and Coyle, J. T. 1998. Markers of glutamatergic neurotransmission and oxidative stress associated with tardive dyskinesia. American Journal of Psychiatry, 155:1207-1213.
33. Cangro, C. B., Namboodiri, M. A. A., Sklar, L. A., Corigliano-Murphy, A., and Neale, J. H. 1987. Immunohistochemistry and biosynthesis and of N-acetylaspartylglutamate in spinal sensory ganglia. J. Neurochem., 49:1579-1588.
34. Reichelt, K. L., and Kvamme, E. 1973. Histamine-dependent formation of N-acetyl-aspartyl peptides in mouse brain. J. Neurochem., 21:849-859.
35. 14C]aspartate. J. Neurochem., 29: 425-431.
36. Lin, S-n, Slopis, J. M., Butler, I. J., and Caprioil, R. M. 1995. In vivo microdialysis and gas chromatography/mass spectrometry for studies on release of N-acetylaspartylglutamate and N-acetylaspartate in rat brain hypothalamus. J. Neuroscience Methods, 62:199-205.
37. Wroblewska, B., Wroblewski, J. T., Pshenichkin, S., Surin, A., Sullivan, S. E., and Neale, J. H. 1997. N-Acetyaspartylglutamate selectively activates mGluR3 receptors in transfected cells. J. Neurochemistry, 69:174-181.
38. Santi, M. R., Wroblewska, B., and Neale, J. H. 1995. NAAG acts through metabotropic glutamate receptors in cultured glial cells. Society. Neuroscience Abstr., 21:847.
39. A α6 subunit in cerebellar granule cells. J. Neurochemistry, 69:2326-2335.
40. Zollinger, M., Amsler, U., Do, K. Q., Streit, P., and Cuenod, M. 1988. Release of N-acetylaspartylglutamate on depolarization of rat brain slices. J. Neurochem., 51:1919-1923.
41. Tsai, G., Stauch, B. L., Vornov, J. J., Deshpande, J. K., and Coyle, J. T. (1990) Selective release of N-acetylaspartylglutamate from rat optic nerve terminals in vivo. Brain Res., 518:313-316.
42. Williamson, L. C., and Neale, J. H. 1988. Ultrastructural localization of N-acetylaspartylglutamate in synaptic vesicles of retinal neurons. Brain Res., 456:375-381.
43. Korf, J., Veenma-van der Duin, L., Venema, K., and Wolf, J. H. (1991) Automated precolumn fluorescence labelling bycarbodiimide activation of N-acetylaspartate and N-acetylaspartylglutamate applied to an HPLC brain tissue analysis. Anal. Biochem., 196:350-355.
44. Miyake, M., and Kakimoto, Y. 1981 Developmental changes of N-acetyl-L-aspartic acid, N-acetyl-α-aspartylglutamic acid and β-citryl-L-glutamic acid in different brain regions and spinal cords of rat and guinea pig. J. Neurochem., 37:1064-1067.
45. Swahn, C-G. 1990. Determination of N-Acetylaspartic acid in human cerebrospinal fluid by gas chromatography-mass spectometry. J Neurochem., 54:1584-1588.
46. Jakobs, C., ten Brink, H. J., Langelaar, S. A., Zee, T., Stellaard, F., Macek, M., Srsnova, K., Srsen, S., and Kleijer, W. J. 1991. Stable isotope dilution analysis of N-acetylaspartic acid in CSF, blood, urine and amniotic fluid: Accurate postnatal diagnosis and the potential for prenatal diagnosis of Canavan disease. J. Inher. Metab. Dis., 14:653-660.
47. Kelley, R. I., and Stamas, J. N. 1992. Quantification of N-acetyl-L-aspartic acid in urine by isotope dilution gas chromatography-mass spectrometry. J. Inher. Metab. Dis., 15:97-104.
48. Rothstein, J. D., Tsai, G., Kuncl, R. W. Clawson, L., Cornblath, D. R., Drachman, D. B., Pestronk, A., Stauch, B. L., and Coyle, J. T. 1990. Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis. Ann. Neurol., 28:18-25.
49. Tsai, G., Passani, L. A., Slusher, B. S., Carter, R., Baer, L., Kleinman, J. E., and Coyle, J. T. 1995. Abnormal excitatory neurotransmitter metabolism in schizophrenic brains. Archives of General Psychiatry, 52:829-836.
50. Tsai, G. E., Ragan, P., Chang, R., Chen, S., Linnoila, U. M., and Coyle, J. T 1998. Increased Glutamatergic Neurotransmission and Oxidative Stress After Alcohol Withdrawal. American Journal of Psychiatry, 155:726-732.
51. Spink, D. C., and Martin, D. L. 1991. Excitatory amino acids in amyotrophic lateral sclerosis. Ann. Neurol., 29:110.
52. Rothstein, J. D., Kuncl, R., Chaudhry, V., Clawson, L., Cornblath, D. R., Coyle, J. T., and Drachman, D. B. 1991. Excitatory amino acids in amyotrophic lateral sclerosis: an update. Ann. Neurol., 30:224-225.
53. Csernansky, J. G., Newcomer, J. W., Jackson, K., Lombrozo, L., Faull, K. F., Zipursky, R., Pfefferbaum, A., and Faustman, W. O. 1994. Effects of raclopride treatment on plasma and CSF HVA: relationships with clinical improvement in male schizophrenics. Psychopharmacology, 116:291-296.
54. Spitzer, R. L., Williams, J. B. W., Gibbon, M., and First, M. B. 1989. Structured clinical interview for DSM-III-R - patient version. Biometrics Research Department, New York State Psychiatric Institute, New York.
55. Americal Psychiatric Association. 1987. Washington, DC., DMS-III-R
56. McKhann, G, Drachman, D, Folstein, M., Katzman, R., Price, D., and stadlan, E. M. 1984. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology, 34:939-944.
57. Khachaturian, Z. S. 1985. Diagnosis of Alzheimer's disease. Arch. Neurol., 42:1097-1105.
58. Jibson, M., Faull, K. F., and Csernansky, J. G. 1990. Intercorrelations among monoamine metabolite concentrations in human lumbar CSF are not due to a shared acid transport system. Biological Psychiatry, 28:595-602.
59. Faull, K. F. DoAmaral, J. R., and Barchas, J. D. 1978. A selected ion monitoring assay for probenecid. Biomed Mass Spectrometry, 5:317-320.
60. Faull, K. F., Anderson, P. J., Barchas, J. D., and Berger, P. A. 1979. Selected ion monitoring assay for biogenic amine metabolites and probenecid in human lumbar cerebrospinal fluid. J Chromatogr Biomed Appl., 163:337-349.
61. Sager, T. N., Laursen, H., and hansen, A. J. 1995. Changes in N-acetyl-aspartate content during focal and global ischemia of the rat. J. Cerebral Blood Flow and Metabolism, 15:639-646.d
62. Harnryd, C., Bjerkenstedt, L., Gullberg, B., Oxenstierna, G., Sedvall, G., and Wiesel, F-A. 1984. Time course for effects of sulpiride and chlorpromazine on monoamine metabolite and prolactin levels in cerebrospinal fluid from schizophrenic patients. Acta Psych. Scand. Suppl. 311:75-92.
63. Forn, J. 1972. Active transport of 5-hydroxyindoleacetic acid by the rabbitt choroid plexus in vitro: Blockage by probenecid and metabolic inhibitors. Biochem. Pharmacol., 21:619-624.
64. Faull, K. F., Barchas, J. D., Foutz, A. S., Dement, W. C., and Holman, R. B. 1982. Monoamine metabolite concentrations in the cerebrospinal fluid of normal and narcoleptic dogs. Brain Res., 242:137-143.
65. Faull, K. F., Kraemer, H. C., Barchas, J. D., and Berger, P. A. 1981. Clinical application of the probenecid test for measurement of monoamine turnover in the CNS. Biol Psychiatr, 16:879-899. Published correction: Faull, K. F., Kraemer, H. C., Barchas, J. D., and Berger, P. A. 1988. Correction: Probenecid monoamine test. Biol. Psychiatr., 24:960.
66. Berger, P. A., Faull, K. F., Kilkowski, J., Anderson, P. J., Kraemer, H., Davis, K. L., and Barchas, J. D. 1980 CSF monoamine metabolites in depression and schizophrenia. Am J Psychiatry 137:174-180. Published correction: Faull, K. F., Berger, P. A., Kilkowski, J., Anderson, P. J., Kraemer, H., Davis, K. L., and Barchas, J. D. 1989. Corrections to a 1980 article on CSF monomine metabolites. Am. J. Psychiatriatry, 146:118.
67. Gonzalez-Mora, J. L., Maidment, N. T., Guadalupe, T., and Mas, M. 1989. Post-mortem dopamine dynamics assessed by voltammetry and microdialysis. Brain Reseach Bulletin, 23: 323-327.
68. Maidment, N. T., Siddall, B., Rudolph, V. D., and Evans, C. J. 1991. Postmortem changes in rat brain extracellular opioid peptides revealed by microdialysis. Journal of Neurochemistry, 56:1980-1984.