메뉴 건너뛰기




Volumn 3, Issue 1, 1998, Pages 14-18

Molecular mechanisms for the senescent cell cycle arrest

Author keywords

Cyclin dependent kinases; G1 cyclins; p16(Ink4a); p21(Sdi1,Cip1,Waf1)

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLINE; DNA; ENZYME INHIBITOR; PROTEIN P16; PROTEIN P21; RETINOBLASTOMA PROTEIN;

EID: 0031754316     PISSN: 10870024     EISSN: None     Source Type: Journal    
DOI: 10.1038/jidsymp.1998.5     Document Type: Conference Paper
Times cited : (52)

References (53)
  • 1
    • 0027331491 scopus 로고
    • Investigation of the role of Gl/S cell cycle mediators in cellular senescence
    • Afshari CA, Vojta PJ, Annab LA, Futreal PA, Willard TD, Barret! JO Investigation of the role of Gl/S cell cycle mediators in cellular senescence. Exp Cell Res 209:231-237, 1993
    • (1993) Exp Cell Res , vol.209 , pp. 231-237
    • Vojta, P.J.1    Annab, L.A.2    Futreal, P.A.3    Willard, T.D.4    Barret, J.O.5
  • 2
    • 0030477686 scopus 로고    scopus 로고
    • Involvement of the cyclindependent kinase inhibitor p!6 (Ink4a) in rcplicative senescence of normal human fibroblasts
    • Alcorta DA, Xiong Y, Hannon G, Beach D, Barrett JC: Involvement of the cyclindependent kinase inhibitor p!6 (Ink4a) in rcplicative senescence of normal human fibroblasts. Pmc Xatt AcaJ Sa USA 93:13742-13747, 1996
    • (1996) Pmc Xatt AcaJ Sa USA , vol.93 , pp. 13742-13747
    • Alcorta, D.A.1    Xiong, Y.2    Hannon, G.3    Beach, D.4    Barrett, J.C.5
  • 4
    • 0026699714 scopus 로고
    • Fibroblasts in normal and pathological terminal differentiation, aging, apoptosis and transformation
    • Bayreuther K, Francz PI, Rodemann HP: Fibroblasts in normal and pathological terminal differentiation, aging, apoptosis and transformation. Arch Cerontol Ccriatr Supplement 3:47-74, 1992
    • (1992) Arch Cerontol Ccriatr Supplement , vol.3 , pp. 47-74
    • Bayreuther, K.1    Francz, P.I.2    Rodemann, H.P.3
  • 5
    • 0028261160 scopus 로고
    • Escape from senescence in human diploid fibroblasts induced directly by mutant p53
    • Bond JA, Wyllie FS, Wynford-Thomas D: Escape from senescence in human diploid fibroblasts induced directly by mutant p53. Oacogene 9:1885-1889, 1994
    • (1994) Oacogene , vol.9 , pp. 1885-1889
    • Bond, J.A.1    Wyllie, F.S.2    Wynford-Thomas, D.3
  • 6
    • 0029827323 scopus 로고    scopus 로고
    • Cyclin E/CDK2 activity is controlled by different mechanisms in the GO and Gl phases of the cell cycle
    • Bresnahan WA, Boldogh I, Ma T, Albrecht T, Thompson EA: Cyclin E/CDK2 activity is controlled by different mechanisms in the GO and Gl phases of the cell cycle. Cell Crou-th Differentiation 7:1283-1290, 1996
    • (1996) Cell Crou-th Differentiation , vol.7 , pp. 1283-1290
    • Bresnahan, W.A.1    Boldogh, I.2    Ma, T.3    Albrecht, T.4    Thompson, E.A.5
  • 7
    • 0030609861 scopus 로고    scopus 로고
    • Bypass of senescence after disruption of p21Cipl/Wafl gene in normal diploid human fibroblasts
    • Brown JP, Wei W, Sedivy JM: Bypass of senescence after disruption of p21Cipl/Wafl gene in normal diploid human fibroblasts. Science 277:831- 834, 1997
    • (1997) Science , vol.277 , pp. 831-834
    • Brown, J.P.1    Wei, W.2    Sedivy, J.M.3
  • 8
    • 0030964277 scopus 로고    scopus 로고
    • The biology of replicative senescence
    • CampisiJ: The biology of replicative senescence. EurJ Cancer 33:703-709, 1997
    • (1997) EurJ Cancer , vol.33 , pp. 703-709
    • CampisiJ1
  • 11
    • 0015580671 scopus 로고
    • Cellular senescence and DNA synthesis
    • Cristofalo VJ, Sharf BB: Cellular senescence and DNA synthesis. Exp Cell Res 76:419-427, 1973
    • (1973) Exp Cell Res , vol.76 , pp. 419-427
    • Cristofalo, V.J.1    Sharf, B.B.2
  • 12
    • 0027970713 scopus 로고
    • DNA damage triggers a prolonged p53-dependent Gl arrest and long-term induction of Cipl in normal human fibroblasts
    • DiLeonardo A, Linke SP, Clarkin K, Wahl GM: DNA damage triggers a prolonged p53-dependent Gl arrest and long-term induction of Cipl in normal human fibroblasts. Ccncs Dcv 8:2540-2551, 1994
    • (1994) Ccncs Dcv , vol.8 , pp. 2540-2551
    • Dileonardo, A.1    Linke, S.P.2    Clarkin, K.3    Wahl, G.M.4
  • 13
    • 0028361374 scopus 로고
    • Regulation of two E2F-reIaied genes in presenescent and senescent human fibroblasts
    • Dimri GP, Hara E, Campisi J: Regulation of two E2F-reIaied genes in presenescent and senescent human fibroblasts. J Bid Client 269:16180-16186, 1994
    • (1994) J Bid Client , vol.269 , pp. 16180-16186
    • Dimri, G.P.1    Hara, E.2    Campisi, J.3
  • 14
    • 0029047362 scopus 로고
    • A biomarker that identifies senescent human cells in culture and in aging skin in vivo
    • Dimri GP, Lee X, Basile G, et ah A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Pmc Natl AcaJ Sei USA 92:9363-9367, 1995
    • (1995) Pmc Natl AcaJ Sei USA , vol.92 , pp. 9363-9367
    • Dimri, G.P.1    Lee, X.2    Basile, G.3
  • 15
    • 0027332123 scopus 로고
    • Altered regulation of Gl cyclins in senescent human diploid fibroblasts: Accumulation of inactive cyclin E-CDK2 and cyclin D1-CDK2 complexes
    • Dulic V, Drullinger LF, Lees E, Reed SI, Stein GH: Altered regulation of Gl cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-CDK2 and cyclin D1-CDK2 complexes. Proc Natl AcaJ Sei USA 90:11034-11038, 1993
    • (1993) Proc Natl AcaJ Sei USA , vol.90 , pp. 11034-11038
    • Dulic, V.1    Drullinger, L.F.2    Lees, E.3    Reed, S.I.4    Stein, G.H.5
  • 16
    • 0028220204 scopus 로고
    • P53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced Gl arrest
    • Dulic V, Kaufmann WK, Wilson SJ, et al: p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced Gl arrest. Cell 76:1013-1023, 1994
    • (1994) Cell , vol.76 , pp. 1013-1023
    • Dulic, V.1    Kaufmann, W.K.2    Wilson, S.J.3
  • 17
    • 0031594705 scopus 로고    scopus 로고
    • Nuclear accumulation of p21c'P' at the onset of mitosis: A role at the G2/M phase transition
    • Dulic V, Stein GH, Far D, Reed SI: Nuclear accumulation of p21c'P' at the onset of mitosis: a role at the G2/M phase transition. Mol Cell Biol 18: 1998
    • (1998) Mol Cell Biol , vol.18
    • Dulic, V.1    Stein, G.H.2    Far, D.3    Reed, S.I.4
  • 18
    • 0028294605 scopus 로고
    • WAF1/CIP1 is induced in p53-mediated Gl arrest and apoptosis
    • El-Deiry WS, Harper JW, O'Connor PM, et al: WAF1/CIP1 is induced in p53-mediated Gl arrest and apoptosis. Cancer Res 55:1169-1174, 1994
    • (1994) Cancer Res , vol.55 , pp. 1169-1174
    • El-Deiry, W.S.1    Harper, J.W.2    O'Connor, P.M.3
  • 19
    • 0030924438 scopus 로고    scopus 로고
    • Hypo - Phosphorylation of the retinoblastoma protein (pRb) by cyclin D.CDK4/6 complexes results in active pRb
    • Ezhevsky SA, Nagahara H, Vocero-Akbani AM, Gius D, Wei MC, Dowdy SF: Hypo - phosphorylation of the retinoblastoma protein (pRb) by cyclin D.CDK4/6 complexes results in active pRb. Pmc i\atl AcaJ Sei USA 94:10699-10704, 1997
    • (1997) Pmc I\atl AcaJ Sei USA , vol.94 , pp. 10699-10704
    • Ezhevsky, S.A.1    Nagahara, H.2    Vocero-Akbani, A.M.3    Gius, D.4    Wei, M.C.5    Dowdy, S.F.6
  • 21
    • 0029763526 scopus 로고    scopus 로고
    • Regulation of dihydrofolate reductase gene expression and E2F components in human diploid fibroblasts during growth and senescence
    • Good L, Dimri GP, Campisi J, Chen KY: Regulation of dihydrofolate reductase gene expression and E2F components in human diploid fibroblasts during growth and senescence. J Cell Physiol 168:580-588, 1996
    • (1996) J Cell Physiol , vol.168 , pp. 580-588
    • Good, L.1    Dimri, G.P.2    Campisi, J.3    Chen, K.Y.4
  • 22
    • 0027976669 scopus 로고
    • Id- Related genes encoding helix-loop-helix proteins are required for Gl progression and are repressed in senescent human fibroblasts
    • Hara E, Yamaguchi T, Nojima H, Ide T, Campisi J, Okayama H, Oda K: Id- related genes encoding helix-loop-helix proteins are required for Gl progression and are repressed in senescent human fibroblasts. J Bid Chcm 269:2139-2145, 1994
    • (1994) J Bid Chcm , vol.269 , pp. 2139-2145
    • Hara, E.1    Yamaguchi, T.2    Nojima, H.3    Ide, T.4    Campisi, J.5    Okayama, H.6    Oda, K.7
  • 24
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley CB, Futcher AB, Greider CW: Telomeres shorten during ageing of human fibroblasts. Nature 345:458-460, 1990
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 25
  • 27
    • 0028924516 scopus 로고
    • Increased p53 protein associated with aging in human diploid fibroblasts
    • Kulju KS, Lehman JM: Increased p53 protein associated with aging in human diploid fibroblasts. Exp Cell Res 217:336-345, 1995
    • (1995) Exp Cell Res , vol.217 , pp. 336-345
    • Kulju, K.S.1    Lehman, J.M.2
  • 28
    • 0030973878 scopus 로고    scopus 로고
    • New functional activities for the p21 family of CDK inhibitors
    • LaBaerJ, Garrett MD, Stevenson LF, et ah New functional activities for the p21 family of CDK inhibitors. Go Dev 11:847-862, 1997
    • (1997) Go Dev , vol.11 , pp. 847-862
    • LaBaer1    Garrett, M.D.2    Stevenson, L.F.3
  • 29
    • 0026793281 scopus 로고
    • Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts
    • Millis AJT, Hoyle M, McCue HM, Martini H: Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts. Exp Cell Res 201:373-379, 1992
    • (1992) Exp Cell Res , vol.201 , pp. 373-379
    • Millis, A.J.T.1    Hoyle, M.2    McCue, H.M.3    Martini, H.4
  • 30
    • 0026526437 scopus 로고
    • E2F: A link between the Rb tumor suppressor protein and viral oncoproteins
    • Nevins JR: E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Scieme 258:424-429, 1992
    • (1992) Scieme , vol.258 , pp. 424-429
    • Nevins, J.R.1
  • 31
    • 0028342664 scopus 로고
    • Cloning of senescent cellderived inhibitors of DNA synthesis using an expression screen
    • Noda A, Ning Y, Venable SF, Pereira-Smith OM, Smidi JR: Cloning of senescent cellderived inhibitors of DNA synthesis using an expression screen. Exp Cell Res 211:90-98, 1994
    • (1994) Exp Cell Res , vol.211 , pp. 90-98
    • Noda, A.1    Ning, Y.2    Venable, S.F.3    Pereira-Smith, O.M.4    Smidi, J.R.5
  • 32
    • 0028146852 scopus 로고
    • Global change of gene expression at the late Gl/S boundary may occur in human IMR-90 diploid fibroblasts during senescence
    • PangJH, Chen KY: Global change of gene expression at the late Gl/S boundary may occur in human IMR-90 diploid fibroblasts during senescence. J Cell Physiol 160:531-538, 1994
    • (1994) J Cell Physiol , vol.160 , pp. 531-538
    • Pang, J.H.1    Chen, K.Y.2
  • 33
    • 0024473604 scopus 로고
    • Gl events and regulation of proliferation
    • Pardee A: Gl events and regulation of proliferation. Scicwe 246:603-608, 1989
    • (1989) Scicwe , vol.246 , pp. 603-608
    • Pardee, A.1
  • 34
    • 0011208723 scopus 로고
    • Genetic analysis of indefinite division in human cells: Identification of four complementation groups
    • Pereira-Smith OM, Smith JR: Genetic analysis of indefinite division in human cells: Identification of four complementation groups. PK>C Natt Acaâ Sei USA 85:6042-6048, 1988
    • (1988) PK>C Natt Acaâ Sei USA , vol.85 , pp. 6042-6048
    • Pereira-Smith, O.M.1    Smith, J.R.2
  • 35
    • 0030927929 scopus 로고    scopus 로고
    • Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution
    • Planas-Silva MD, Weinberg RA: Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution. Mol Ceil Bid 17:4059-4069, 1997
    • (1997) Mol Ceil Bid , vol.17 , pp. 4059-4069
    • Planas-Silva, M.D.1    Weinberg, R.A.2
  • 36
    • 0003876138 scopus 로고    scopus 로고
    • Regulation of p21Sdil/Cipl/Wafl/mda-6 and expression of other cyclic- Dependent kinase inhibitors in senescent human cells
    • Robetorye RS, Nakanishi M, Venable SF, Pereira-Smith OM, Smith JR: Regulation of p21Sdil/Cipl/Wafl/mda-6 and expression of other cyclic- dependent kinase inhibitors in senescent human cells. Molee Cell D//T4:113-126, 1996
    • (1996) Molee Cell D//T , vol.4 , pp. 113-126
    • Robetorye, R.S.1    Nakanishi, M.2    Venable, S.F.3    Pereira-Smith, O.M.4    Smith, J.R.5
  • 37
    • 0024534983 scopus 로고
    • Selective enrichment and biochemical characterization of seven human skin fibroblast cell types in vitro
    • Rodemann HP, Bayreuther K, Franz PI, Dittman K, Albiez M: Selective enrichment and biochemical characterization of seven human skin fibroblast cell types in vitro. Exp Cell Res 180:84-93, 1989
    • (1989) Exp Cell Res , vol.180 , pp. 84-93
    • Rodemann, H.P.1    Bayreuther, K.2    Franz, P.I.3    Dittman, K.4    Albiez, M.5
  • 38
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • Serrano M, Hannon GJ, Beach D: A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366:704-707, 1993
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 39
    • 0025052004 scopus 로고
    • Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts
    • Seshadri T, Campisi J: Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts. Science 247:205-209, 1990
    • (1990) Science , vol.247 , pp. 205-209
    • Seshadri, T.1    Campisi, J.2
  • 40
    • 0031594707 scopus 로고    scopus 로고
    • P6Ink4A participates in a Gl arrest checkpoint in response to DNA damage
    • Shapiro Gl, Edwards CD, Ewen ME, Rollins BJ: p!6Ink4A participates in a Gl arrest checkpoint in response to DNA damage. Mol Cell Bio! 18:378-387, 1998
    • (1998) Mol Cell Bio! , vol.18 , pp. 378-387
    • Gl, S.1    Edwards, C.D.2    Ewen, M.E.3    Rollins, B.J.4
  • 41
    • 0027496456 scopus 로고
    • The frequency of immortalization of human fibroblasts and mammary epithelial cells transfected with SV40 large T-antigen
    • Shay JW, Van Der Haegen BA, Ting Y, Wright WE: The frequency of immortalization of human fibroblasts and mammary epithelial cells transfected with SV40 large T-antigen. Exp Cell Res 209:45-52, 1993a
    • (1993) Exp Cell Res , vol.209 , pp. 45-52
    • Shay, J.W.1    Van Der Haegen, B.A.2    Ting, Y.3    Wright, W.E.4
  • 42
    • 0027263711 scopus 로고
    • E6 of human papillomavirus type 16 can overcome the Ml stage of immortalization in human mammary epithelial cells but not in human fibroblasts
    • Shay JW, Wright WE, Brasiskyte D, Van der Haegen DA: E6 of human papillomavirus type 16 can overcome the Ml stage of immortalization in human mammary epithelial cells but not in human fibroblasts. Oncogene 8:1407-1413, 1993b
    • (1993) Oncogene , vol.8 , pp. 1407-1413
    • Shay, J.W.1    Wright, W.E.2    Brasiskyte, D.3    Van Der Haegen, D.A.4
  • 43
    • 0028171292 scopus 로고
    • Gl phase progression: Cycling on cue
    • Sherr CJ: Gl phase progression: cycling on cue. Cell 79:551-555, 1994
    • (1994) Cell , vol.79 , pp. 551-555
    • Sherr, C.J.1
  • 44
    • 0028988585 scopus 로고
    • Inhibitors of mammalian Gl cyclin-dependent kinases
    • Sherr CJ, Roberts JM: Inhibitors of mammalian Gl cyclin-dependent kinases. Coin Dcv 9:1149-1163, 1995
    • (1995) Coin Dcv , vol.9 , pp. 1149-1163
    • Sherr, C.J.1    Roberts, J.M.2
  • 45
    • 0022258793 scopus 로고
    • SV40-transformed human fibroblasts: Evidence for cellular aging in pre-crisis cells
    • Stein GH: SV40-transformed human fibroblasts: evidence for cellular aging in pre-crisis cells. J Cell Physiol 125:36-44, 1985
    • (1985) J Cell Physiol , vol.125 , pp. 36-44
    • Stein, G.H.1
  • 46
    • 0021894216 scopus 로고
    • Relationship of finite proliferative life-span, senescence, and quiescence in human cells
    • Stein GH, Namba M, Corsaro CM: Relationship of finite proliferative life-span, senescence, and quiescence in human cells. J Cell Physiol 122:343-349, 1985
    • (1985) J Cell Physiol , vol.122 , pp. 343-349
    • Stein, G.H.1    Namba, M.2    Corsaro, C.M.3
  • 47
    • 0025150387 scopus 로고
    • Failure to phosphors-late the retinoblastoma gene product in senescent human fibroblasts
    • Stein GH, Beeson M, Gordon L: Failure to phosphors-late the retinoblastoma gene product in senescent human fibroblasts. Science 249:666-669, 1990
    • (1990) Science , vol.249 , pp. 666-669
    • Stein, G.H.1    Beeson, M.2    Gordon, L.3
  • 50
    • 0024445960 scopus 로고
    • Replicative senescence of human skin fibroblasts correlates with a loss of regulation and ovcrexpression of collagenase activity
    • West MD, Pereira-Smith OM, Smith JR: Replicative senescence of human skin fibroblasts correlates with a loss of regulation and ovcrexpression of collagenase activity. Exp Cell Res 184:138-147, 1989
    • (1989) Exp Cell Res , vol.184 , pp. 138-147
    • West, M.D.1    Pereira-Smith, O.M.2    Smith, J.R.3
  • 52
    • 0016438899 scopus 로고
    • Prematurely condensed chromosomes of dividing and non-dividing cells in aging human cell cultures
    • Yanishevsky R, Carrano AV: Prematurely condensed chromosomes of dividing and non-dividing cells in aging human cell cultures. Exp Cell Res 90:169-174, 1975
    • (1975) Exp Cell Res , vol.90 , pp. 169-174
    • Yanishevsky, R.1    Carrano, A.V.2
  • 53
    • 0028169236 scopus 로고
    • P21-containing cyclin kinases exist in both active and inactive states
    • Zhang H, Hannon GJ, Beach D: p21-containing cyclin kinases exist in both active and inactive states. Genes Dcv 8:1750-1758, 1994
    • (1994) Genes Dcv , vol.8 , pp. 1750-1758
    • Zhang, H.1    Hannon, G.J.2    Beach, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.