Maturation of steroid receptors: An example of functional cooperation among molecular chaperones and their associated proteins

Cell Stress and Chaperones

Volumn 5, Issue 2, 2000, Pages 76-86

  Kimmins, S ^a   MacRae, T H ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 70; RECEPTOR PROTEIN; STEROID; STEROID RECEPTOR;

GENETIC TRANSCRIPTION; HORMONE RECEPTOR INTERACTION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; REVIEW; SIGNAL TRANSDUCTION;

HUMULUS;

EID: 0033636957     PISSN: 13558145     EISSN: None     Source Type: Journal    
DOI: 10.1379/1466-1268(2000)005<0076:MOSRAE>2.0.CO;2     Document Type: Review

References (106)

1. HSP90 interacts with and regulates the activity of heat shock factor 1 in Xenopus oocytes
2. BAG-1, anegative regulator of hsp70 chaperone activity, uncouples nucleotide hydrolysis from substrate release
3. Genetic and biochemical analysis of p23 and ansamycin antibiotics in the function of Hsp90-dependent signaling proteins
4. Chaperone function of Hsp90-associated proteins
5. Hsp90 and Co. - A holding for folding
6. The Hsp70 and Hsp60 chaperone machines
7. Growing up in a dangerous environment: A network of multiple targeting and folding pathways for nascent polypeptides in the cytosol
8. A conserved proline in the hsp90 binding region of the glucocorticoid receptor is required for hsp90 heterocomplex stabilization and receptor signaling
9. Hsp90's secrets unfold: New insights from structural and functional studies
10. The common tetratricopeptide repeat acceptor site for steroid receptor-associated immunophilins and hop is located in the dimerization domain of Hsp90
11. In vivo analysis of the Hsp90 cochaperone Stil (p60)
12. Hop as an adaptor in the heat shock protein 70 (Hsp70) and Hsp90 chaperone machinery
13. Differential interactions of p23 and the TPR-containing proteins Hop, Cyp40, FKBP52and FKBP51 with Hsp90 mutants
14. Interactions of p60, amediator of progesterone receptor assembly, with heat shock proteins hsp90 and hsp70
15. Evidence thagt the FK506-binding immunophilin heat shock protein 56 is required for trafficking of the glucocorticoid receptor from the cytoplasm to the nucleus
16. The hsp56 immunophilin component of untransformed steroid receptor complexes is localized both to microtubules in the cytoplasm and to the same nonrandom regions within the nucleus as the steroid receptor
17. Intragenic suppressors of Hsp70 mutants: Interplay between the ATPase- and peptide-binding domains
18. The carboxy-terminal domain of Hsc70 provides binding sites for a distinct set of chaperone cofactors
19. Overexpression of HSP-70 inhibits the phosphorylation of HSF1 by activating protein phosphatase and inhibiting protein kinase C activity
20. The role of DnaJ-like proteins in glucocorticoid receptor.hsp90 heterocomplex assembly by the reconstituted hsp90.p60.hsp70 foldosome complex
21. Folding of the glucocorticoid receptor by the heat shock protein (hsp) 90-based chaperone machinery. The role of p23 is to stabilize receptor.hsp90 heterocomplexes formed by hsp90.p60.hsp70
22. Folding of the glucocorticoid receptor by the reconstituted hsp90-based chaperone machinery. The initial hsp90.p60.hsp70-dependent step is suffident for creating the steroid binding conformation
23. CNS1 encodes an essential p60/Sti1 homolog in Saccharomyces cerevisiae that suppresses cyclophilin 40 mutations and interacts with Hsp90
24. Requirement for Hsp90 and a CyP-40-type cyclophilin in negative regulation of the heat shock response
25. A cyclophilin function in Hsp90-dependent signal transduction
26. Complexes between nascent polypeptides and their molecular chaperones in the cytosol of mammalian cells
27. SBA1 encodes a yeast Hsp90 cochaperone that is homologous to vertebrate p23 proteins
28. Hsp90 regulates androgen receptor hormone binding affinity in vivo
29. Molecular chaperone machines: Chaperone activities of the cydophilin Cyp-40 and the steroid aporeceptor-associated protein p23
30. Chaperones get in touch: The Hip-Hop conection
31. Interference between proteins Hap46 and Hop/p60, which bind to different domains of the molecular chaperone hsp70/hsc70
32. Role of the J-domain in the cooperation of Hsp40 and Hsp70
33. The importance of ATP binding and hydrolysis by Hsp90 in formation and function of protein heterocomplexes
34. The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation
35. Molecular chaperones in cellular protein folding
36. Hip, a novel cochaperone involved in the eukaryotic Hsc70/Hsp40 reaction cycle
37. Characterization of functional domains of the eukaryotic co-chaperone Hip
38. Functional specificity among Hsp70 molecular chaperones
39. Delimitation of two regions of the 90-kDa heat shock protein (Hsp90) able to interact with the glucocorticosteroid receptor (GR)
40. Mapping the role of active site residues for transducing an ATP-induced conformational change in the bovine 70-kDa heat shock cognate protein
41. Hop modulates Hsp70/Hsp90 interactions in protein folding
42. Binding of p23 and hsp90 during assembly with the progesterone receptor
43. Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes
44. A novel chaperone complex for steroid receptors involving heat shock proteins, immunophilins, and p23
45. Heat shock protein 70 family: Multiple sequence comparisons, function, andevolution
46. The J-domain family and the recruitment of chaperone power
47. Interaction between Hsc70 and DnaJ homologues: Relationship between Hsc70 polymerization and ATPase activity
48. Role of the protein chaperone YDJ1 in establishing Hsp90-mediated signal transduction pathways
49. Role for Hsp90-associated co-chaperone p23 in estrogen receptor signal transduction
50. The assembly of progesterone receptor-hsp90 complexes using purified proteins
51. RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis
52. Mechanism of regulation of Hsp70 chaperones by DnaJ cochaperones
53. Quantification of the nucleocytoplasmic distribution of wild type and modified proteins using confocal microscopy: Interaction between 90-kDa heat shock protein (Hsp90alpha) and glucocorticosteroid receptor (GR)
54. Molecular chaperones and the cytoskeleton
55. The biochemical properties of the ATPase activity of a 70-kDa heat shock protein (HSP70) are governed by the C-terminal domains
56. The conserved carboxy terminus and zinc finger-like domain of the co-chaperone Ydj1 assist Hsp70 in protein folding
57. Protein folding activity of Hsp70 is modified differentially by the Hsp40 co-chaperones Sis1 and Ydj1
58. Cns1 is an essential protein associated with the Hsp90 chaperone complex in Saccharomyces cerevisiae that can restore cyclophilin 40-dependent functions in cpr7Delta cells
59. Monomer arrangement in HSP90 dimer as determined by decoration with N and C-terminal region specific antibodies
60. Investigation of the interaction between DnaK and DnaJ by surface plasmon resonance spectroscopy
61. J proteins catalytically activate Hsp70 molecules to trap a wide range of peptide sequences
62. High-resolution solution structure of the 18 kDa substrate-binding domain of the mammalian chaperone protein Hsc70
63. Mammalian cytosolic DnaJ homologues affect the hsp70 chaperone-substrate reaction cycle, but do not interact directly with nascent or newly synthesized proteins
64. Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor
65. In vivo functions of the Saccharomyces cerevisiae Hsp90 chaperone
66. In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis
67. A model of protein targeting mediated by immunophilins and other proteins that bind to hsp90 via tetratricopeptide repeat domains
68. The cyclosporin A-binding immunophilin CyP-40 and the FK506-binding immunophilin hsp56 bind to a common site on hsp90 and exist in independent cytosolic heterocomplexes with the untransformed glucocorticoid receptor
69. ATP binding and hydrolysis are essential to the function of Hsp90 molecular chaperone in vivo
70. The molecular chaperone Ssb from Saccharomyces cerevisiae is a component of the ribosome-nascent chain complex
71. Reduced levels of hsp90 compromise steroid receptor action in vivo
72. Control of the DnaK chaperone cycle by substoichiometric concentrations of the co-chaperones DnaJ and GrpE
73. Mutation of Hip's carboxy-terminal region inhibits a transitional stage of progesterone receptor assembly
74. Molecular cloning of human p48, atransient component of progesterone receptor complexes and an Hsp70-binding protein
75. Mutational analysis of the hsp70-interacting protein Hip
76. Chaperone functions of the heat shock proteins associated with steroid receptors
77. Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones
78. Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
79. Molecular chaperones: Towards a characterization of the heat-shock protein 70 family
80. Cyclophilin 40 (CyP-40), mapping of its hsp90 binding domain and evidence that FKBP52 competes with CyP-40 for hsp90 binding
81. Glucocorticoid resistance in the squirrel monkey is associated with overexpression of the immunophilin FKBP51
82. Identification of conserved residues required for the binding of a tetratricopeptide repeat domain to heat shock protein 90
83. DnaJ dramatically stimulates ATP hydrolysis by DnaK: Insight into targeting of Hsp70 proteins to polypeptide substrates
84. Hsp90 as a capacitor for morphological evolution
85. Protein folding and the regulation of signaling pathways
86. The charged region of Hsp90 modulates the function of the N-terminal domain
87. Two chaperone sites in Hsp90 differing in substrate specificity and ATP dependence
88. A heat shock protein complex isolated from rabbit reticulocyte lysate can reconstitute a functional glucocorticoid receptor-Hsp90 complex
89. Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70
90. A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity
91. Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones
92. Conformational activation of a basic helix-loop-helix protein (MyoD1) by the C-terminal region of murine HSP90 (HSP84)
93. Dynamics of heat shock protein 90-progesterone receptor binding and the disactivation loop model for steroid receptor complexes
94. Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70
95. Steroid receptors and their associated proteins
96. Purification of unactivated progesterone receptor and identification of novel receptor-associated proteins
97. KF25706, anovel oxime derivative of radicicol, exhibitsin vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules
98. Signal transducer and activator of transcription-1 and heat shock factor-1 interact and activate the transcription of the Hsp-70 and Hsp-90beta gene promoters
99. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators
100. Recent advances in the study of hsp90 structure and mechanism of action
101. Is Hsp90 a regulator of evolvability?
102. NMR solution structure of the 21 kDa chaperone protein DnaK substrate binding domain: A preview of chaperone-protein interaction
103. Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90
104. Binding of hsp90 to the glucocorticoid receptor requires a specific 7-amino acid sequence at the aminoterminus of the hormone-binding domain
105. Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90
106. Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1