A conserved proline in the hsp90 binding region of the glucocorticoid receptor is required for hsp90 heterocomplex stabilization and receptor signaling

Journal of Biological Chemistry

Volumn 273, Issue 32, 1998, Pages 20473-20480

  Caamaño, Claudio A ^a,b   Morano, M Inés ^a   Dalman, Friedrich C ^a,c   Pratt, William B ^a   Akil, Huda ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; GLUCOCORTICOID RECEPTOR; HEAT SHOCK PROTEIN 90; PROLINE;

ARTICLE; BINDING SITE; COMPLEX FORMATION; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN STABILITY; RECEPTOR INTRINSIC ACTIVITY; RECEPTOR OCCUPANCY; SIGNAL TRANSDUCTION; STEROID BINDING;

ANIMALS; COS CELLS; DNA-BINDING PROTEINS; HSP90 HEAT-SHOCK PROTEINS; MOLECULAR CHAPERONES; MUTAGENESIS; PROLINE; PROTEIN BINDING; RATS; RECEPTORS, GLUCOCORTICOID; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 0032493733     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.32.20473     Document Type: Article

References (18)

1. Catelli, M. G., Binart, N., Jung-Testas, I., Renoir, J. M., Baulieu, E. E., Feramisco, J. R., and Welch, W. J. (1985) EMBO J. 4, 3131-3135
2. Joab, I., Radanyi, C., Renoir, M., Buchou, T., Catelli, M. G., Binart, N., Mester, J., and Baulieu, E. E. (1984) Nature 308, 850-853
3. Sanchez, E. R, Toft, D. O., Schlesinger, M. J., and Pratt, W. B. (1985) J. Biol. Chem. 260, 12398-12401
4. Renoir, J. M., Radanyi, C., Faber, L. E., and Baulieu, E. E. (1990) J. Biol. Chem. 265,10740-10745
5. Schuh, S., Yonemoto, W., Brugge, J., Bauer, V. J., Riehl, R. M, Sullivan, W. P., and Toft, D. O. (1985) J. Biol. Chem. 260, 14292-14296
6. Pratt, W. B. (1993) J. Biol. Chem. 268, 21455-21458
7. Smith, D. F., and Toft, D. O. (1993) Mol. Endocrinol. 7, 4-11
8. Pratt, W. B., and Toft, D. O. (1997) Endocrinol. Rev. 18, 306-360
9. McBlain, W. A., Toft, D. O., and Shyamala, G. (1981) Biochemistry 20, 6790-6798
10. Holbrook, N. J., Bodwell, J. E., Jeffries, M., and Munck, A. (1983) J. Biol. Chem. 258, 6477-6485
11. Pratt, W. B. (1992) Bioessays 14, 841-848
12. Picard, D., Khursheed, B., Garabedian, M. J., Fortin, M. G., Lindquist, S., and Yamamoto, K R. (1990) Nature 348, 166-168
13. Bohen, S. P., and Yamamoto, K. R. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 11424-11428
14. Nathan, D. F., and Lindquist, S. (1995) Mol. Cell. Biol. 15, 3917-3925
15. Segnitz, B., and Gehring, U. (1997) J. Biol. Chem. 272, 18694-18701
16. Czar, M. J., Galigniana, M. D., Silverstein, A. M., and Pratt, W. B. (1997) Biochemistry 36, 7776-7785
17. Bamberger, C. M., Wald, M., Bamberger, A. M., and Schulte, H. M. (1997) Mol. Cell. Endocrinol. 131, 233-240
18. Caamaño, C. A., Morano, M. I., Patel, P. D., Watson, S. J., and Akil, H. (1993) Biochemistry 32, 8589-8595