Prevention of early myocardial depression in hyperdynamic endotoxemia in dogs

Shock

Volumn 13, Issue 1, 2000, Pages 46-51

  Wolfárd, Antal ^a   Kaszaki, József ^a   Szabó, Csaba ^b   Szalay, László ^a   Nagy, Sándor ^a   Boros, Mihály ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Mercaptoethylguanidine; Myocardial contractility; Nitric oxide synthase activity; Oxygen free radicals; Polymorphonuclear leukocytes

Indexed keywords

1 (2 MERCAPTOETHYL)GUANIDINE; 2-MERCAPTOETHYLGUANIDINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTOXIN; ENZYME INHIBITOR; GUANIDINE DERIVATIVE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE; PHORBOL 13 ACETATE 12 MYRISTATE; SCAVENGER;

ANIMAL; ARTICLE; BLOOD PRESSURE; DOG; DRUG ANTAGONISM; DRUG EFFECT; ENDOTOXEMIA; ESCHERICHIA COLI; HEART CONTRACTION; HEART MUSCLE; HEART OUTPUT; HEMODYNAMICS; IN VITRO STUDY; METABOLISM; NEUTROPHIL; PATHOPHYSIOLOGY; PHYSIOLOGY; SEPSIS;

ANIMALS; BLOOD PRESSURE; CARDIAC OUTPUT; DOGS; ENDOTOXEMIA; ENDOTOXINS; ENZYME INHIBITORS; ESCHERICHIA COLI; FREE RADICAL SCAVENGERS; GUANIDINES; HEMODYNAMIC PROCESSES; MYOCARDIAL CONTRACTION; MYOCARDIUM; NEUTROPHILS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; SEPSIS; TETRADECANOYLPHORBOL ACETATE;

EID: 0033629690     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-200013010-00009     Document Type: Article

References (35)

1. Szabó C, Mitchell JA, Thiemermann C, Vane JR: Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxin shock. Br J Pharmacol 108:786-792, 1993.
2. Parratt JR: Nitric oxide in sepsis and endotoxemia. J Antimicrob Chemother 41:31-39, 1998.
3. Ishiwata T, Guo F, Naito Z, Asano G, Nishigaki R: Differential distribution of ecNOS and iNOS mRNA in rat heart after endotoxin administration. Jpn Heart J 38:445-455, 1997..
4. Sun X, Delbridge LM, Dusting GJ: Cardiodepressant effects of interferon-gamma and endotoxin reversed by inhibition of NO synthase 2 in rat myocardium. J Mol Cell Cardiol 30:989-997, 1998.
5. Johnson ML, Billiar TR: Roles of nitric oxide in surgical infection and sepsis. World J Surg 22:187-196, 1998.
6. Kaszaki J, Wolfárd A, Bari F, Boros M, Parratt JR, Nagy S: Effect of nitric oxide synthase inhibition on myocardial contractility in anesthetized normal and endotoxemic dogs. Shock 6:279-285, 1996.
7. Bateson AN, Jakiwczyk OM, Schulz R: Rapid increase in inducible nitric oxide synthase gene expression in the heart during endotoxemia. Eur J Pharmacol 303:141-144, 1996.
8. Jaeschke H, Smith CW: Mechanisms of neutrophil-induced parenchymal cell injury. J Leukoc Biol 61:647-653, 1997.
9. Granton JT, Goddard CM, Allard MF, vanEeden S, Walley KR: Leukocytes and decreased left-ventricular contractility during endotoxemia in rabbits. Am J Respir Crit Care Med 155:1977-1983, 1997.
10. Deitch EA: Animal models of sepsis and shock: a review and lessons learned. Shock 9:1-11, 1998.
11. Southan GJ, Szabó C, Thiemermann C: Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity. Br J Pharmacol 114:510-516, 1995.
12. Southan GJ, Zingarelli B, O'Connor M, Salzmann AL, Szabó C: Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform. Br J Pharmacol 117:619-632, 1996.
13. Szabó C, Ferrer-Sueta G, Zingarelli B, Southan GJ, Salzmann AL, Radi R: Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage. J Biol Chem 272:9030-9036, 1997.
14. Panas D, Khadour FH, Szabó C, Schulz R: Proinflammatory cytokines depress cardiac efficiency by a nitric oxide-dependent mechanism. Am J Physiol 275:H1016-H1023, 1998.
15. Teitel DF, Klautz R, Steendijk P, van der Velde ET, van Bel F, Baan J: The end-systolic pressure-volume relationship in the newborn lamb: effects of loading and inotropic interventions. Pediatr Res 29:473-482, 1991.
16. Goldfarb RD: Cardiac mechanical performance in circulatory shock: A critical review of methods and results. Circ Shock 9:633-653, 1982.
17. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ: Protein measurement with the phenol reagent. J Biol Chem 193:265-275, 1951.
18. Guarnieri C, Melandri G, Caldarera I, Schaeda M, Ligabue A, Guizzardi S, Branzi A: Reduced oxidative activity of circulating neutrophils in patients after myocardial infarction. Cell Biochem Funct 8:157-162, 1990.
19. Kuebler WM, Abels C, Schuerer L, Goetz AE: Measurement of neutrophil content in brain and lung tissue by a modified myeloperoxidase assay. Int J Microcirc Clin Exp 16:89-97, 1996.
20. Vincent JL: Cardiovascular alterations in septic shock. J Antimicrob Chemother 41:9-15, 1998.
21. Ruokonen E, Takala J, Kari A, Saxen H, Mertsola J, Hansen EJ: Regional blood flow and oxygen transport in septic shock. Crit Care Med 21:1296-1303, 1993.
22. Szabó A, Hake P, Salzmann AL, Szabó C: Beneficial effects of mercaptoethylguanidine, an inhibitor of the inducible nitic oxide synthase and a scavenger of peroxynitrite, in a porcine model of delayed hemorrhagic shock. Crit Care Med (in press).
23. 2+ -independent nitric oxide synthases. FEBS Lett 291:145-149, 1991.
24. 2+-independent nitric oxide synthase in the myocardium. Br J Pharmacol 105:575-580, 1992.
25. Liu S, Adcock IA, Old RW, Barnes PJ, Evans TW: Lipopolysaccharide treatment in vivo induces widespread tissue expression of inducible nitric oxide synthase mRNA. Biochem Biophys Res Commun 196:1208-1213, 1993.
26. Herbertson MJ, Werner HA, Walley KR: Nitric oxide synthase inhibition partially prevents decreased LV contractility during endotoxemia. Am J Physiol 270:H1979-H1984, 1996.
27. Lloyd SS, Chang AK, Taylor FB, Janzen EG, McCay PB: Fr radicals and septic shock in primates: the role of tumor necrosis factor. Free Radic Biol Med 14:233-242, 1993.
28. Bloomfield GL, Rigings PC, Blocher CR, Fisher BJ, Sugerman HJ, Nagamoto H, Fowler AA: OPC-6535, a superoxide anion production inhibitor, attenuates acute lung injury. J Surg Res 72:70-77, 1997.
29. Galley HF, Howdle PD, Walker BE, Webster NR: The effects of intravenous antioxidants in patients with septic shock. Free Radic Biol Med 23:768-774, 1997.
30. Goode HF, Webster NR: Free radicals and antioxidants in sepsis. Crit Care Med 21:1770-1776, 1993.
31. Forehande JR, Pabst MJ, Philips WA, Johnston RB: Lipopolysaccharide priming of human neutrophils for an enhanced respiratory burst. J Clin Invest 83:74-83, 1989.
32. Kapoor R, Prasad K: Role of oxyradicals in cardiovascular depression and cellular injury in hemorrhagic shock and reinfusion: Effect of SOD and catalase. Circ Shock 43:79-94, 1994.
33. Redl H, Nikolai A, Kneidinger R, Schlag G: Endothelial and leukocyte activation in experimental polytrauma and sepsis. Behring Inst Mitt 92: 218-228, 1993.
34. McGill SN, Ahmed NA, Christou NV: Endothelial cells: Role in infection and inflammation. World J Surg 22:171-178, 1998.
35. Kilbourn RG, Szabó C, Traber DL: Beneficial versus detrimental effects of nitric oxide synthase inhibitors in circulatory shock: Lessons learned from experimental and clinical studies. Shock 7:235-246, 1997.