Exploratory solid-phase synthesis of factor Xa inhibitors: Discovery and application of P3-heterocyclic amides as novel types of non-basic arginine surrogates

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 24, 1999, Pages 3459-3464

  Ho, Jonathan Z ^a   Levy, Odile E ^a   Gibson, Tony S ^a   Nguyen, Khanh ^a   Semple, J Edward ^a  

^a Dendreon   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; BLOOD CLOTTING FACTOR 10A INHIBITOR; DEXTRO ARGININE; DIAMINOBUTYRIC ACID; FIBRIN; HETEROCYCLIC COMPOUND; THROMBIN; TRYPSIN;

ARTICLE; DRUG DESIGN; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; IN VITRO STUDY; INHIBITION KINETICS; STRUCTURE ACTIVITY RELATION;

EID: 0033590270     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00628-9     Document Type: Article

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