Potent dipeptide inhibitors of the pp60(c-src) SH2 domain

Journal of Medicinal Chemistry

Volumn 41, Issue 11, 1998, Pages 1894-1908

  Pacofsky, Gregory J ^a   Lackey, Karen ^a   Alligood, Krystal J ^a   Berman, Judd ^a   Charifson, Paul S ^a,b   Crosby, Renae M ^a   Dorsey Jr , George F ^a   Feldman, Paul L ^a   Gilmer, Tona M ^a   Hummel, Conrad W ^a,c   Jordan, Steven R ^a,c   Mohr, Christopher ^a   Shewchuk, Lisa M ^a   Sternbach, Daniel D ^a   Rodriguez, Marc ^a,d  

^a GLAXOSMITHKLINE   (United States)

^b VERTEX PHARMACEUTICALS   (United States)

^c AMGEN INC   (United States)

^d Neosystem   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG ANALOG; PROTEIN KINASE P60; PROTEIN KINASE P60 INHIBITOR; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; LIGAND BINDING; NONHUMAN; PROTEIN DOMAIN; PROTEIN FAMILY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; DIPEPTIDES; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTO-ONCOGENE PROTEINS PP60(C-SRC); SRC HOMOLOGY DOMAINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 15644372860     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970853a     Document Type: Article

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