Phosphotyrosine-containing dipeptides as high-affinity ligands for the p56(lck) SH2 domain

Journal of Medicinal Chemistry

Volumn 42, Issue 4, 1999, Pages 722-729

  Llinàs Brunet, Montse ^a   Beaulieu, Pierre L ^a   Cameron, Dale R ^a   Ferland, Jean Marie ^a   Gauthier, Jean ^a   Ghiro, Elise ^a   Gillard, James ^a   Gorys, Vida ^a   Poirier, Martin ^a   Rancourt, Jean ^a   Wernic, Dominik ^a   Betageri, Raj ^b   Cardozo, Mario ^b   Jakes, Scott ^b   Lukas, Suzanne ^b   Patel, Usha ^b   Proudfoot, John ^b   Moss, Neil ^b  

^a BOEHRINGER INGELHEIM CANADA LTD   (Canada)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLAMINE DERIVATIVE; CARBOXYL GROUP; DIPEPTIDE; GLUTAMIC ACID; LEUCINE; LIGAND; PHENYL GROUP; PHOSPHOTYROSINE; PROTEIN TYROSINE KINASE; TETRAPEPTIDE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR MODEL; PROTEIN DOMAIN; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE;

BINDING, COMPETITIVE; DIPEPTIDES; ENZYME INHIBITORS; LIGANDS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MODELS, MOLECULAR; PHOSPHOTYROSINE; SRC HOMOLOGY DOMAINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0344450777     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980612i     Document Type: Article

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