Loss of heterozygosity and microsatellite instability at the retinoblastoma locus in osteosarcomas

Diagnostic Molecular Pathology

Volumn 5, Issue 3, 1996, Pages 214-219

  Belchis, Deborah A ^a,c   Meece, Christine A ^a   Benko, Floyd A ^a   Rogan, Peter K ^a   Williams, Roger A ^b   Gocke, Christopher D ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b CHILDREN S HOSPITAL OAKLAND   (United States)

^c PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

Loss of heterozygosity; Microsatellite instability; Osteosarcoma; Polymerase chain reaction; Retinoblastoma gene

Indexed keywords

MICROSATELLITE DNA;

ARTICLE; CANCER GENETICS; DNA DETERMINATION; GENE LOCUS; HETEROZYGOSITY; HUMAN; HUMAN TISSUE; OSTEOSARCOMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOUTHERN BLOTTING; TUMOR SUPPRESSOR GENE;

BONE NEOPLASMS; CHROMOSOME ABERRATIONS; CHROMOSOME DISORDERS; CHROMOSOME MAPPING; DNA, SATELLITE; GENES, RETINOBLASTOMA; HETEROZYGOTE; HUMANS; MUTATION; OSTEOSARCOMA; POLYMERASE CHAIN REACTION;

EID: 0029789170     PISSN: 10529551     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019606-199609000-00011     Document Type: Article

References (30)

1. Aaltonen LA, Peltomaki P, Leach FS, et al. Clues to the pathogenesis of familial colorectal cancer. Science 1993;260: 812-6.
2. Araki N, Uchida A, Kimura T, et al. Involvement of the retinoblastoma gene in primary osteosarcomas and other bone and soft tissue tumors. Clin Orthop 1991;270:271-7.
3. Arnold A. Genetic basis of endocrine disease: molecular genetics of parathyroid gland neoplasia. J Clin Endocrinol Metab 1993;77:1108-12.
4. Cordon-Cardo C. Mutation of cell cycle regulators: biological and clinical implications for human neoplasia. Am J Pathol 1995;147:545-60.
5. Cordon-Cardo C, Wartinger D, Petrylak D, et al. Altered expression of the retinoblastoma gene product: prognostic indicator in bladder cancer. J Natl Cancer Inst 1992;84: 1251-6.
6. Eyfjord JE, Thorlacius S, Steinarsdottir M, Valgardsdottir R, Ogmundsdottir HM, Anamthawat-Jonsson K. p53 Abnormalities and genomic instability in primary human breast carcinomas. Cancer Res 1995;55:646-51.
7. Fong KM, Zimmerman PV, Smith PJ. Microsatellite instability and other molecular abnormalities in non-small cell lung cancer. Cancer Res 1995;55:28-30.
8. Hamel PA, Phillips RA, Muncaster M, Gallie BL. Speculations on the roles of RB1 in tissue-specific differentiation, tumor initiation, and tumor progression. FASEB J 1993;7: 846-54.
9. Hansen MF. Molecular genetic considerations in osteosarcoma. Clin Orthop 1991;270:237-46.
10. Hansen M, Koufos A, Gallie B, et al. Osteosarcoma and retinoblastoma: a shared chromosomal mechanism revealing recessive predisposition. Proc Natl Acad Sci USA 1985;82: 6216-20.
11. Heyn R, Haeberlen V, Newton WA, et al. Second malignant neoplasms in children treated for rhabdomyosarcoma. J Clin Oncol 1993;11:262-70.
12. Huang H-JS, Yee JK, Shew JY, et al. Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. Science 1988;242:1563-6.
13. Kim H, Jen J, Vogelstein B, Hamilton SR. Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. Am J Pathol 1994;145:148-56.
14. Loeb LA. Microsatellite instability: marker of a mutator phenotype in cancer. Cancer Res 1994;54:5059-63.
15. Logothetis CJ, Xu H-J, Ro JY, et al. Altered expression of retinoblastoma protein and known prognostic variables in locally advanced bladder cancer. J Natl Cancer Inst 1992; 84:1256-61.
16. Rosai J. Ackerman's surgical pathology, 8th ed. St. Louis: Mosby-Year Book, Inc., 1996.
17. Sambrook J, Fritsch E, Maniatis T. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 1989.
18. Sarkar FH, Li Y-W, Crissman JD. A method for PCR sequencing of the p53 gene from a single 10-μm frozen or paraffin-embedded tissue section. Biotechniques 1993;15: 36-8.
19. Scheffer H, Kruize YC, Osinga J, et al. Complete association of loss of heterozygosity of chromosomes 13 and 17 in osteosarcoma. Cancer Genet Cytogenet 1991;53:45-55.
20. Scholz R, Kabisch H, Weber B, Roser K, Delling G, Winkler K. Studies of the RB1 gene and the p53 gene in human osteosarcomas. Pediatr Hematol Oncol 1992;9:125-37.
21. Shew J-Y, Lin B, Chen P-L, Tseng B, Yang-feng T, Le W-H. C-terminal truncation of the RB protein leads to functional inactivation. Proc Natl Acad Sci USA 1990;87:6.
22. Thibodeau SN, Bren G, Schaid D. Microsatellite instability in cancer of the proximal colon. Science 1993;260:816-9.
23. Toguchida J, Ishizaki K, Sasaki M, et al. Chromosomal reorganization for the expression of recessive mutation of retinoblastoma susceptibility gene in the development of osteosarcoma. Cancer Res 1988;48:3939-43.
24. Wadayama B, Toguchida J, Shimizu T, et al. Mutation spectrum of the retinoblastoma gene in osteosarcomas. Cancer Res 1994;54:3042-8.
25. Weinberg R. Tumor suppressor genes. Science 1991;254: 1138-46.
26. Wiman KG. The retinoblastoma gene: role in cell cycle control and cell differentiation. FASEB J 1993;7:841-5.
27. Wunder JS, Czitrom AA, Kandel R, Andrulis IL. Analysis of alterations in the retinoblastoma gene and tumor grade in bone and soft-tissue sarcomas. J Natl Cancer Inst 1991;83: 194-200.
28. Xu H-J, Quinlan DC, Davidson AG, et al. Altered retinoblastoma protein expression and prognosis in early-stage non-small-cell lung carcinoma. J Natl Cancer Inst 1994;86: 695-9.
29. Yamaguchi T, Toguchida J, Yamauro T, et al. Allelotype analysis in osteosarcomas: frequent allele loss on 3q, 13q, 17p and 18q. Cancer Res 1992;52:2419-23.
30. Zhou Y, Li J, Xu K, Hu S-X, Benedict W, Xu H-J. Further characterization of retinoblastoma gene-mediated cell growth and tumor suppression in human cancer cells. Proc Natl Acad Sci USA 1994;91:4165-9.