How efficacious are 5-HT(1B/D) receptor ligands: An answer from GTPγS binding studies with stably transfected C6-glial cell lines

Neuropharmacology

Volumn 36, Issue 4-5, 1997, Pages 499-512

  Pauwels, P J ^a   Tardif, S ^a   Palmier, C ^a   Wurch, T ^a   Colpaert, F C ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

35S GTP S binding; Agonist; Antagonist A; Efficacy; Inverse agonist; Rat C6 glial cell line; Recombinant h5 HT(1B) and h5 HT(1D) receptor

Indexed keywords

5 CARBAMOYLTRYPTAMINE; CP 122638; CYCLIC AMP; DIHYDROERGOTAMINE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); KETANSERIN; METITEPINE; N [4 [5 [3 (2 AMINOETHYL) 1H INDOL 5 YL] 1,2,4 OXADIAZOL 3 YL]BENZYL]METHANESULFONAMIDE; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; NARATRIPTAN; PARTIAL AGONIST; RADIOLIGAND; RECEPTOR SUBTYPE; RIZATRIPTAN; SEROTONIN 1B RECEPTOR; SEROTONIN 1D RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR AFFECTING AGENT; SUMATRIPTAN; UNCLASSIFIED DRUG; ZOLMITRIPTAN; LIGAND; RECOMBINANT PROTEIN; SEROTONIN RECEPTOR;

AGONIST; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL LINE; CELL MEMBRANE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG INHIBITION; DRUG POTENCY; DRUG POTENTIATION; GENETIC TRANSFECTION; GLIA CELL; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; RECEPTOR INTRINSIC ACTIVITY; RECOMBINANT DNA TECHNOLOGY; SIGNAL TRANSDUCTION; BIOSYNTHESIS; DRUG EFFECT; GENETICS; GLIA; MEMBRANE; METABOLISM; PLASMID; RADIOASSAY;

CELL LINE; CYCLIC AMP; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HELA CELLS; HUMANS; LIGANDS; MEMBRANES; NEUROGLIA; PLASMIDS; RADIOLIGAND ASSAY; RECEPTORS, SEROTONIN; RECOMBINANT PROTEINS; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; TRANSFECTION;

EID: 0030610861     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(96)00170-0     Document Type: Article

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