Amino acid substitutions in the pore of rat glutamate receptors at sites influencing block by polyamines

Journal of Physiology

Volumn 520, Issue 2, 1999, Pages 337-357

  Panchenko, Victor A ^a   Glasser, Carla R ^a   Partin, Kathryn M ^a,b   Mayer, Mark L ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b Immunology and Pathology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR ANTAGONIST; KAINIC ACID RECEPTOR; MUTANT PROTEIN; POLYAMINE; SPERMINE; TRYPTOPHAN; ASPARTIC ACID; GLUTAMATE RECEPTOR 6; GLUTAMIC ACID; IMIDAZOLE; PROTON;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG RECEPTOR BINDING; EMBRYO; EMBRYO CELL; HUMAN; HUMAN CELL; HYDROPHOBICITY; IONIZATION; KIDNEY CELL; MULTIGENE FAMILY; OOCYTE; PRIORITY JOURNAL; XENOPUS; ACTION POTENTIAL AMPLITUDE; ANIMAL CELL; ANIMAL EXPERIMENT; BINDING SITE; ELECTROPHYSIOLOGY PARAMETERS; FEMALE; GENE MUTATION; MEMBRANE CONDUCTANCE; MEMBRANE POTENTIAL; MOLECULAR INTERACTION; NEGATIVE CHARGE; NONHUMAN; OUTWARD RECTIFYING CURRENT; RAT; RECEPTOR BLOCKING; WILD TYPE; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL LINE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MEMBRANE POTENTIALS; MOLECULAR SEQUENCE DATA; MUTATION; OOCYTES; PATCH-CLAMP TECHNIQUES; POLYAMINES; PROTEIN BINDING; RATS; RECEPTORS, KAINIC ACID; RNA, COMPLEMENTARY; SEQUENCE ALIGNMENT; SPERMINE; TRANSFECTION; XENOPUS;

EID: 0033569459     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1999.t01-1-00337.x     Document Type: Article

References (51)

1. ANTONOV, S. M., GMIBO, V. E. & JOHNSON, J. W. (1998). Binding sites for permeant ions in the channel of NMDA receptors and their effects on channel block. Nature Neuroscience 1, 451-461.
2. BÄHRING, R., BOWIE, D., BENVENISTE, M. & MAYER, M. L. (1997). Permeation and block of rat GluR6 glutamate receptor channels by internal and external polyamines. Journal of Physiology 502, 575-589.
3. BECK, C., WOLLMUTH, L. P., SEEBURG, P. H., SAKMANN, B. & KUNER, T. (1999). NMDAR channel segments forming the extracellular vestibule inferred from the accessibility of substituted cysteines. Neuron 22, 559-570.
4. BENNETT, J. A. & DINGLEDINE, R. (1995). Topology profile for a glutamate receptor: Three transmembrane domains and a channellining re-entrant membrane loop. Neuron 14, 373-384.
5. BOWIE, D., LANGE, G. D. & MAYER, M. L. (1998). Activity-dependent modulation of glutamate receptors by polyamines. Journal of Neuroscience 18, 8175-8185.
6. BOWIE, D. & MAYER, M. L. (1995). Inward rectification of both AMPA and kainate subtype glutamate receptors generated by polyamine-mediated ion channel block. Neuron 15, 453-462.
7. BURNASHEV, N., ZHOU, Z., NEHER, E. & SAKMANN, B. (1995). Fractional calcium currents through recombinant GIuR channels of the NMDA, AMPA and kainate receptor subtypes. Journal of Physiology 485, 403-418.
8. BURNASHEV, N., VILLARROEL, A. & SAKMANN, B. (1996). Dimensions and ion selectivity of recombinant AMPA and kainate receptor channels and their dependence on Q/R site residues. Journal of Physiology 496, 165-173.
9. CREIGHTON, T. E. (1993). Proteins: Structures and Molecular Properties. W. H. Freeman and Co., New York.
10. CUI, C., BÄHRING, R. & MAYER, M. L. (1998). The role of hydrophobic interactions in binding of polyamines to non NMDA receptor ion channels. Neuropharmacology 37, 1381-1391.
11. CURUTCHET, P., BOCHET, P., PRADO DE CARVALHO, L., LAMBOLEZ, B., STINNAKRE, J. & ROSSIER, J. (1992). In the GluR1 glutamate receptor subunit a glutamine to histidine point mutation suppresses inward rectification but not calcium permeability. Biochemical and Biophysical Research Communications 182, 1089-1093.
12. DELA VEGA, A. L. & DELCOUR, A. H. (1995). Cadaverine induces closing of E. coli porins. EMBO Journal 14, 6058-6065.
13. DINGLEDINE, R., BORGES, K., BOWIE, D. & TRAYNELIS, S. F. (1999). The glutamate receptor ion channels. Pharmacology Reviews 51, 7-45.
14. DINGLEDINE, R., HUME, R. I. & HEINEMANN, S. F. (1992). Structural determinants of barium permeation and rectification in non-NMDA glutamate receptor channels. Journal of Neuroscience 12, 4080-4087.
15. DOUGHERTY, D. A. (1996). Cation-π interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. Science 271, 163-168.
16. + conduction and selectivity. Science 280, 69-77.
17. EVERTS, I., PETROSKI, R., KIZELSZTEIN, P., TEICHBERG, V. I., HEINEMANN, S. F. & HOLLMANN, M. (1999). Lectin-induced inhibition of desensitization of the kainate receptor GluR6 depends on the activation state and can be mediated by a single native or ectopic N-linked carbohydrate side chain. Journal of Neuroscience 19, 916-927.
18. + channels is caused by intracellular spermine. Cell 80, 149-154.
19. HAGHIGHI, A. P. & COOPER, E. (1998). Neuronal nicotinic acetylcholine receptors are blocked by intracellular spermine in a voltage-dependent manner. Journal of Neuroscience 18, 4050-4062.
20. HEGINBOTHAM, L. & MACKINNON, R. (1992). The aromatic binding site for tetraethylammonium ion on potassium channels. Neuron 8, 483-491.
21. HERB, A., HIGUCHI, M., SPRENGEL, R. & SEEBURG, P. H. (1996). Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences. Proceedings of the National Academy of Sciences of the USA 93, 1875-1880.
22. HIGUCHI, M., SINGLE, F. N., KÖHLER, M., SOMMER, B., SPRENGEL, R. & SEEBURG, P. H. (1993). RNA editing of AMPA receptor subunit GluR-B: a base-paired intron-exon structure determines position and efficiency. Cell 75, 1361-1370.
23. HOLLMANN, M., MARON, C. & HEINEMANN, S. (1994). N-Glycosylation site tagging suggests a three transmembrane domain topology for the glutamate receptor GluR1. Neuron 13, 1331-1343.
24. KEINANEN, K., WISDEN, W., SOMMER, B., WERNER, P., HERB, A., VERDOORN, T. A., SAKMANN, B. & SEEBURG, P. H. (1990). A family of AMPA-selective glutamate receptors. Science 249, 556-560.
25. KUNER, T., BECK, C., SEEBURG, P. H. & SAKMANN, B. (1997). Porelining residues of the AMPA receptor channel M2 segment. Society for Neuroscience Abstracts 23, 925.
26. KUNER, T., WOLLMUTH, L. P., KARLIN, A., SEEBURG, P. H. & SAKMANN, B. (1996). Structure of the NMDA receptor channel M2 segment inferred from the accessibility of substituted cysteines. Neuron 17, 343-352.
27. + channel determined by construction of multimeric cDNAs. Neuron 9, 861-871.
28. LU, Z. & DING, L. (1999). Blockade of a retinal cGMP-gated channel by polyamines. Journal of General Physiology 113, 35-43.
29. MILEDI, R. & PARKER, I. (1984). Chloride current induced by injection of calcium into Xenopus oocytes. Journal of Physiology 357, 173-183.
30. NICHOLS, C. G. & LOPATIN, A. N. (1997). Inward rectifier potassium channels. Annual Review of Physiology 59, 171-191.
31. + channels. Biophysical Journal 74, 2318-2326.
32. PARKER, I. & MILEDI, R. (1998). A calcium-independent chloride current activated by hyperpolarization in Xenopus oocytes. Proceedings of the Royal Society B 233, 191-199.
33. PARTIN, K. M., PATNEAU, D. K., WINTERS, C. A., MAYER, M. L. & BUONANNO, A. (1993). Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A. Neuron 11, 1069-1082.
34. PEARSON, W. L. & NICHOLS, C. G. (1998). Block of the Kir2.1 channel pore by alkylamine analogues of endogenous polyamines. Journal of General Physiology 112, 351-63.
35. 2+-permeable AMPA receptor channels by activity-dependent relief from polyamine block. Journal of Physiology 511, 361-377,
36. SCHREIBMAYER, W., LESTER, H. A. & DASCAL, N. (1994). Voltage clamping of Xenopus laevis oocytes utilizing agarose-cushion electrodes. Pflügers Archiv 426, 453-458.
37. + channel. Journal of General Physiology 112, 211-221.
38. STERN-BACH, Y., BETTLER, B., HARTLEY, M., SHEPPARD, P. O., O'HARA, P. J. & HEINEMANN, S. F. (1994). Agonist-selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid binding proteins. Neuron 13, 1345-1357.
39. + channels in Xenopus oocytes. Journal of Physiology 503, 547-562.
40. SUGIYAMA, S., MATSUO, Y., MAENAKA, K., VASSYLYEV, D. G., MATSUSHIMA, M., KASHIWAGI, K., IGARASHI, K. & MORIKAWA, K. (1996). The 1·8 Å X-ray structure of the Escherichia coli PotD protein complexed with spermidine and the mechanism of polyamine binding. Protein Science 5, 1984-1990.
41. SWANSON, G. T. & HEINEMANN, S. F. (1998). Heterogeneity of homomeric GluR5 kainate receptor desensitization expressed in HEK293 cells. Journal of Physiology 513, 639-646.
42. SWANSON, G. T., KAMBOJ, S. K. & CULL-CANDY, S. G. (1997). Single-channel properties of recombinant AMPA receptors depend on RNA editing, splice variation, and subunit composition. Journal of Neuroscience 17, 58-69.
43. + sensitivity of excitatory amino acid receptor channels in rat cerebellar granule neurones. Journal of Physiology 433, 727-763.
44. TRAYNELIS, S. F. & WAHL, P. (1997). Control of rat GluR6 glutamate receptor open probability by protein kinase A and calcineurin. Journal of Physiology 503, 513-531.
45. UEHARA, A., FILL, M., VELEZ, P., YASUKOCHI, M. & IMANAOA, I. (1996). Rectification of rabbit cardiac ryanodine receptor current by endogenous polyamines. Biophysical Journal 71, 769-777.
46. VYKLICKY, L., BENVENISTE, M. & MAYER, M. L. (1990). Modulation of N-methyl-D-aspartic acid receptor desensitization by glycine in mouse cultured hippocampal neurones. Journal of Physiology 428, 313-331.
47. WENTHOLD, R. J., TRUMPY, V. A., ZHUI, W. S. & PETRALIA, R. S. (1994). Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family determined with subunit-specific antibodies. Journal of Biological Chemistry 269, 1332-1339.
48. 2+ interacts with structural determinants of the narrow constriction contributed by the NR1-subunit in the NMDA receptor channel. Journal of Physiology 506, 33-52.
49. 2+. Journal of Physiology 506, 13-32.
50. WOODHULL, A. M. (1973). Ionic blockage of sodium channels in nerve. Journal of General Physiology 61, 687-708.
51. ZHANG, Y., MCBRIDE, D. W. JR & HAMILL, O. P. (1998). The ion selectivity of a membrane conductance inactivated by extracellular calcium in Xenopus oocytes. Journal of Physiology 508, 763-776.