A Tumor-Specific Truncated Estrogen Receptor Splice Variant Enhances Estrogen-Stimulated Gene Expression

Molecular Endocrinology

Volumn 12, Issue 9, 1998, Pages 1355-1366

  Chaidarun, Sushela S ^a   Alexander, Joseph M ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIA;

ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR;

ALTERNATIVE RNA SPLICING; ARTICLE; CELL DIFFERENTIATION; CELL LINE; DRUG EFFECT; GENE EXPRESSION; GENETIC TRANSFECTION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; MOLECULAR CLONING; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION;

ALTERNATIVE SPLICING; CELL DIFFERENTIATION; CELL LINE; CLONING, MOLECULAR; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESTRADIOL; ESTROGENS; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; POLYMERASE CHAIN REACTION; RECEPTORS, ESTROGEN; TRANSFECTION;

EID: 0032161804     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.12.9.0170     Document Type: Article

References (45)

1. Horowitz MC 1993 Cytokines and estrogen in bone: antiosteoporotic effects. Science 260:626-627
2. Nabulsi AA, Folsom AR, White A, Patsch W, Heiss G, Wu KK, Szklo M 1993 Association of hormone-replacement therapy with various cardiovascular risk factors in post-menopausal women. The Atherosclerosis Risk in Communities Study Investigators [see comments]. N Engl J Med 328:1069-1075
3. Green S, Walter P, Kumar V, Krust A, Bornert JM, Argos P, Chambon P 1986 Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature 320:134-139
4. Katzenellenbogen BS, Korach KS 1997 Editorial: a new actor in the estrogen receptor drama-enter ER-beta. Endocrinology 138:861-862
5. Ponglikitmongkol M, Green S, Chambon P 1988 Genomic organization of the human oestrogen receptor gene. EMBO J 7:3385-3388
6. Fuqua SA, Wolf DM 1995 Molecular aspects of estrogen receptor variants in breast cancer. Breast Cancer Res Treat 35:233-241
7. Fuqua SA, Allred DC, Auchus RJ 1993 Expression of estrogen receptor variants. J Cell Biochem Suppl 17G:194-197
8. Pfeffer U, Fecarotta E, Vidali G 1995 Coexpression of multiple estrogen receptor variant messenger RNAs in normal and neoplastic breast tissues and in MCF-7 cells. Cancer Res 55:2158-2165
9. Gotteland M, Desauty G, Delarue JC, Liu L, May E 1995 Human estrogen receptor messenger RNA variants in both normal and tumor breast tissues. Mol Cell Endocrinol 112:1-13
10. Rice LW, Jazaeri AA, Shupnik MA 1997 Estrogen receptor mRNA splice variants in pre- and postmenopausal human endometrium and endometrial carcinoma. Gynecol Oncol 65:149-157
11. Skipper JK, Young LJ, Bergeron JM, Tetzlaff MT, Osborn CT, Crews D 1993 Identification of an isoform of the estrogen receptor messenger RNA lacking exon four and present in the brain. Proc Natl Acad Sci USA 90:7172-7175
12. Koehorst SG, Jacobs HM, Thijssen JH, Blankenstein MA 1993 Wild type and alternatively spliced estrogen receptor messenger RNA in human meningioma tissue and MCF7 breast cancer cells. J Steroid Biochem Mol Biol 45:227-233
13. Chaidarun SS, Klibanski A, Alexander JM 1997 Tumor-specific expression of alternatively spliced estrogen receptor messenger ribonucleic acid variants in human pituitary adenomas. J Clin Endocrinol Metab 82:1058-1065
14. Kumar V, Green S, Stack G, Berry M, Jin JR, Chambon P 1987 Functional domains of the human estrogen receptor. Cell 51:941-951
15. Ambrosino C, Cicatiello L, Cobellis G, Addeo R, Sica V, Bresciani F, Weisz A, Tora L 1993 Functional antagonism between the estrogen receptor and Fos in the regulation of c-fos protooncogene transcription. Mol Endocrinol 7:1472-1483
16. Fan JD, Wagner BL, McDonnell DP 1996 Identification of the sequences within the human complement 3 promoter required for estrogen responsiveness provides insight into the mechanism of tamoxifen mixed agonist activity. Mol Endocrinol 10:1605-1616
17. Metzger D, Ali S, Bomert JM, Chambon P 1995 Characterization of the amino-terminal transcriptional activation function of the human estrogen receptor in animal and yeast cells. J Biol Chem 270:9535-9542
18. Horwitz KB, Jackson TA, Bain DL, Richer JK, Takimoto GS, Tung L 1996 Nuclear receptor coactivators and corepressors. Mol Endocrinol 10:1167-1177
19. Kumar V, Chambon P 1988 The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer. Cell 55:145-156
20. Pierrat B, Heery DM, Chambon P, Losson R 1994 A highly conserved region in the hormone-binding domain of the human estrogen receptor functions as an efficient transactivation domain in yeast. Gene 143:193-200
21. Tasset D, Tora L, Fromental C, Scheer E, Chambon P 1990 Distinct classes of transcriptional activating domains function by different mechanisms. Cell 62:1177-1187
22. Webster NJ, Green S, Jin JR, Chambon P 1988 The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function. Cell 54:199-207
23. Fuqua SA, Fitzgerald SD, Chamness GC, Tandon AK, McDonnell DP, Nawaz Z, O'Malley BW, McGuire WL 1991 Variant human breast tumor estrogen receptor with constitutive transcriptional activity. Cancer Res 51:105-109
24. Daffada AA, Johnston SR, Smith IE, Detre S, King N, Dowsett M 1995 Exon 5 deletion variant estrogen receptor messenger RNA expression in relation to tamoxifen resistance and progesterone receptor/pS2 status in human breast cancer. Cancer Res 55:288-293
25. Fujimoto J, Ichigo S, Hirose R, Sakaguchi H, Tamaya T 1997 Expression of estrogen receptor wild type and exon 5 splicing variant mRNAs in normal and endometriotic endometria during the menstrual cycle. Gynecol Endocrinol 11:11-16
26. Leygue E, Huang A, Murphy LC, Watson PH 1996 Prevalence of estrogen receptor variant messenger RNAs in human breast cancer. Cancer Res 56:4324-4327
27. Zhang QX, Borg A, Fuqua SA 1993 An exon 5 deletion variant of the estrogen receptor frequently coexpressed with wild-type estrogen receptor in human breast cancer. Cancer Res 53:5882-5884
28. Castles CG, Fuqua SA, Klotz DM, Hill SM 1993 Expression of a constitutively active estrogen receptor variant in the estrogen receptor-negative BT-20 human breast cancer cell line. Cancer Res 53:5934-5939
29. Huo B, Dossing DA, Dimuzio MT 1995 Generation and characterization of a human osteosarcoma cell line stably transfected with the human estrogen receptor gene. J Bone Miner Res 10:769-781
30. Ikegami A, Inoue S, Hosoi T, Kaneki M, Mizuno Y, Akedo Y, Ouchi Y, Orimo H 1994 Cell cycle-dependent expression of estrogen receptor and effect of estrogen on proliferation of synchronized human osteoblast-like osteosarcoma cells. Endocrinology 135:782-789
31. Migliaccio S, Davis VL, Gibson MK, Gray TK, Korach KS 1992 Estrogens modulate the responsiveness of osteoblast-like cells (ROS 17/2.8) stably transfected with estrogen receptor. Endocrinology 130:2617-2624
32. Watts CK, Parker MG, King RJ 1989 Stable transfection of the oestrogen receptor gene into a human osteosarcoma cell line. J Steroid Biochem 34:483-490
33. Watts CK, King RJ 1994 Overexpression of estrogen receptor in HTB 96 human osteosarcoma cells results in estrogen-induced growth inhibition and receptor cross talk. J Bone Miner Res 9:1251-1258
34. Pakdel F, Reese JC, Katzenellenbogen BS 1993 Identification of charged residues in an N-terminal portion of the hormone-binding domain of the human estrogen receptor important in transcriptional activity of the receptor. Mol Endocrinol 7:1408-1417
35. Tzukerman MT, Esty A, Santiso-Mere D, Danielian P, Parker MG, Stein RB, Pike JW, McDonnell DP 1994 Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions. Mol Endocrinol 8:21-30
36. Wooge CH, Nilsson GM, Heierson A, McDonnell DP, Katzenellenbogen BS 1992 Structural requirements for high affinity ligand binding by estrogen receptors: a comparative analysis of truncated and full length estrogen receptors expressed in bacteria, yeast, and mammalian cells. Mol Endocrinol 6:861-869
37. Beato M, Candau R, Chavez S, Mows C, Truss M 1996 Interaction of steroid hormone receptors with transcription factors involves chromatin remodelling. J Steroid Biochem Mol Biol 56:47-59
38. Tsai MJ, BWO M 1994 Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu Rev Biochem 63:451-486
39. Norris JD, Fan D, Kerner SA, McDonnell DP 1997 Identification of a third autonomous activation domain within the human estrogen receptor. Mol Endocrinol 11:747-754
40. Christman JK, Nehls S, Polin L, Brooks SC 1995 Relationship between estrogen structure and conformational changes in estrogen receptor/DNA complexes. J Steroid Biochem Mol Biol 54:201-210
41. Rea D, Parker MG 1996 Effects of an exon 5 variant of the estrogen receptor in MCF-7 breast cancer cells. Cancer Res 56:1556-1563
42. Weisz A, Rosales R 1990 Identification of an estrogen response element upstream of the human c-fos gene that binds the estrogen receptor and the AP-1 transcription factor. Nucleic Acids Res 18:5097-5106
43. Schreiber E, Matthias P, Muller MM, Schaffner W 1989 Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res 17:1
44. Chaidarun SS, Eggo MC, Stewart PM, Barber PC, Sheppard MC 1994 Role of growth factors and estrogen as modulators of growth, differentiation, and expression of gonadotropin subunit genes in primary cultured sheep pituitary cells. Endocrinology 134:935-944
45. Stanier RV, Adekberg EA, Ingraham JE 1976 The Microbial World. Prentice Hall, Upper Saddle River, NJ, pp 276