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Volumn 121, Issue 36, 1999, Pages 8157-8163

Improved enzyme activity and enantioselectivity in organic solvents by methyl-β-cyclodextrin

Author keywords

[No Author keywords available]

Indexed keywords

CYCLODEXTRIN; ORGANIC SOLVENT; SUBTILISIN;

EID: 0033568044     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja990515u     Document Type: Article
Times cited : (117)

References (77)
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    • Chiral drug market shows signs of maturity
    • (b) Stinson, S. C. Chiral drug market shows signs of maturity. In Chem. Engn. News 1997, October 20.
    • (1997) Chem. Engn. News , vol.20 OCTOBER
    • Stinson, S.C.1
  • 4
    • 0000428089 scopus 로고
    • The application of lipases in organic synthesis
    • (b) Haraldsson, G. G., Ed.The application of lipases in organic synthesis. In Suppl. B: Chem. Acid Deriv. 1992, 2, 1395-1473.
    • (1992) Suppl. B: Chem. Acid Deriv. , vol.2 , pp. 1395-1473
    • Haraldsson, G.G.1
  • 59
    • 0344993294 scopus 로고    scopus 로고
    • note
    • 1,4-Dioxane was chosen as the solvent in the thermal denaturation experiments because of its relatively high boiling point (101.3°C). The enhancements in catalytic rate and enantioselectivity in this solvent when employing the MβCD-subtilisin co-lyophilizate were not as excellent as in THF, but still significant.
  • 64
    • 0344562269 scopus 로고    scopus 로고
    • note
    • 2, and acetonitrile: more than 1 g of MβCD/mL of solvent; in toluene: 0.07 g of MβCD/mL of toluene; in octane: not soluble within detection limits. Note that the additive βCD is not soluble in 1,4-dioxane, THF, and acetonitrile and that only a marginal increase in the enzyme enantioselectivity and in the reaction rates was observed with this additive.
  • 70
    • 0344130726 scopus 로고    scopus 로고
    • note
    • 22b no method has been established to achieve activation of CLECs in organic solvents.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.